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Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.

Publication ,  Journal Article
Andonian, BJ; Koss, A; Koves, TR; Hauser, ER; Hubal, MJ; Pober, DM; Lord, JM; MacIver, NJ; St Clair, EW; Muoio, DM; Kraus, WE; Bartlett, DB ...
Published in: Sci Rep
May 6, 2022

Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic oxidative metabolism) and thus may impact RA T cell oxidative metabolic function. In this pilot study of RA participants, we took advantage of heterogeneous responses to a high-intensity interval training (HIIT) exercise program to identify relationships between improvements in cardiorespiratory fitness with changes in peripheral T cell and skeletal muscle oxidative metabolism. In 12 previously sedentary persons with seropositive RA, maximal cardiopulmonary exercise tests, fasting blood, and vastus lateralis biopsies were obtained before and after 10 weeks of HIIT. Following HIIT, improvements in RA cardiorespiratory fitness were associated with changes in RA CD4 + T cell basal and maximal respiration and skeletal muscle carnitine acetyltransferase (CrAT) enzyme activity. Further, changes in CD4 + T cell respiration were associated with changes in naïve CD4 + CCR7 + CD45RA + T cells, muscle CrAT, and muscle medium-chain acylcarnitines and fat oxidation gene expression profiles. In summary, modulation of cardiorespiratory fitness and molecular markers of skeletal muscle oxidative metabolism during exercise training paralleled changes in T cell metabolism. Exercise training that improves RA cardiorespiratory fitness may therefore be valuable in managing pathologically related immune and muscle dysfunction.Trial registration: ClinicalTrials.gov, NCT02528344. Registered on 19 August 2015.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 6, 2022

Volume

12

Issue

1

Start / End Page

7450

Location

England

Related Subject Headings

  • Pilot Projects
  • Oxidative Stress
  • Muscle, Skeletal
  • Humans
  • Cardiorespiratory Fitness
  • Arthritis, Rheumatoid
 

Citation

APA
Chicago
ICMJE
MLA
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Andonian, B. J., Koss, A., Koves, T. R., Hauser, E. R., Hubal, M. J., Pober, D. M., … Huffman, K. M. (2022). Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness. Sci Rep, 12(1), 7450. https://doi.org/10.1038/s41598-022-11458-4
Andonian, Brian J., Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal, David M. Pober, Janet M. Lord, et al. “Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.Sci Rep 12, no. 1 (May 6, 2022): 7450. https://doi.org/10.1038/s41598-022-11458-4.
Andonian BJ, Koss A, Koves TR, Hauser ER, Hubal MJ, Pober DM, et al. Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness. Sci Rep. 2022 May 6;12(1):7450.
Andonian, Brian J., et al. “Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.Sci Rep, vol. 12, no. 1, May 2022, p. 7450. Pubmed, doi:10.1038/s41598-022-11458-4.
Andonian BJ, Koss A, Koves TR, Hauser ER, Hubal MJ, Pober DM, Lord JM, MacIver NJ, St Clair EW, Muoio DM, Kraus WE, Bartlett DB, Huffman KM. Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness. Sci Rep. 2022 May 6;12(1):7450.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

May 6, 2022

Volume

12

Issue

1

Start / End Page

7450

Location

England

Related Subject Headings

  • Pilot Projects
  • Oxidative Stress
  • Muscle, Skeletal
  • Humans
  • Cardiorespiratory Fitness
  • Arthritis, Rheumatoid