Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina at Chapel Hill 1999
• 

  Duke Appointment History

  • Associate Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011 - 2016
  • Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011 - 2016
  • Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2008 - 2011
  • Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2004 - 2011
  • Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2004 - 2008
  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2004
• 

  Leadership & Clinical Positions at Duke

  • Director, Basic Science Research
    Duke Molecular Physiology Institute
• Recognition
• 

  In the News

  • JUL 9, 2015

    Daily Telegraph

    Supplement allows elderly people to exercise more rigorously

  • JAN 22, 2015

    Scientific American

    Commentary: How overeating may contribute to a metabolic ‘traffic jam’
• Expertise
• 

  Subject Headings

  • Diabetes
  • Exercise--Physiological aspects
  • Metabolism
  • Mitochondria
  • Muscles--Physiology
  • Obesity
• Research
• 

  Selected Grants

  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells awarded by National Institutes of Health 2017 - 2022
  • STIM1 and metabolic flexibility awarded by National Institutes of Health 2017 - 2022
  • Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • 13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis awarded by National Institutes of Health 2017 - 2020
  • Microbial regulation of host nutrient metabolism awarded by National Institutes of Health 2013 - 2020
  • Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
  • Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic Function awarded by National Institutes of Health 2010 - 2019
  • Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2018
  • Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
  • Organic Cations and Mitochondrial Efficiency awarded by East Carolina University 2016 - 2018
  • Mitochondrial Protein Acetylation and Energy Metabolism in Muscle awarded by National Institutes of Health 2015 - 2018
  • Carnitine Acetyltransferase and Metabolic Regulation in the Exocrine Pancreas awarded by National Institutes of Health 2015 - 2017
  • Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
  • Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides awarded by National Institutes of Health 2013 - 2016
  • Iron homeostasis in mammalian muscle awarded by National Institutes of Health 2011 - 2016
  • Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
  • Mechanisms of Insulin Resistance in Rheumatoid Arthritis awarded by National Institutes of Health 2008 - 2015
  • Behavior And Physiology In Aging awarded by National Institutes of Health 1999 - 2015
  • Instrumentation for Quantitative Phosphoproteomics and Acetylomics awarded by National Institutes of Health 2014 - 2015
  • Exercise Dose-Response Effects in Prediabetes:Responses and Mechanisms awarded by National Institutes of Health 2009 - 2015
  • Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle awarded by National Institutes of Health 2011 - 2014
  • Role of Carnitine Acetyltansferase in Combatting Nutrient Stress awarded by National Institutes of Health 2011 - 2014
  • Mechanisms of Insulin Resistance in Rheumatoid Arthritis awarded by National Institutes of Health 2008 - 2013
  • Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance awarded by National Institutes of Health 2006 - 2012
  • Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity awarded by National Institutes of Health 2007 - 2010
  • Regulation and metabolic impact of mitochondrial CD36 in skeletal muscle awarded by National Institutes of Health 2006 - 2009
  • Role of carnitine acetyltransferase in mitochondrial function and insulin action awarded by National Institutes of Health 2007 - 2009
  • Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
  • Ketone Dysregulation and Muscle Insulin Resistance awarded by National Institutes of Health 2004 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Keenan, MM, Liu, B, Tang, X, Wu, J, Cyr, D, Stevens, RD, Ilkayeva, O, Lucas, J, Muoio, DM, Kim, SY, and Chi, J-T. "Abstract 3004: Contextual RNAi screen identifies ACLY and ACC1 as mediators of hypoxia-induced apoptosis through metabolic and transcriptional mechanisms." August 1, 2015.  Full Text
    • Keenan, MM, Liu, B, Wu, J, Cyr, D, Lucas, J, Muoio, DM, Kim, SY, and Chi, J-T. "Abstract PR09: A genome-wide RNAi screen reveals a protective role of decreased lipogenesis under hypoxia." January 1, 2015.  Full Text
    • Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood." April 2013.  Link to Item
    • Glynn, EL, An, J, Wang, L-P, Ilkayeva, OR, Stevens, RD, Bain, JR, Muehlbauer, MJ, Koves, TR, Summers, SA, Muoio, DM, and Newgard, CB. "Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity." April 2012.  Link to Item
    • Kien, CL, Bunn, JY, Champagne, CM, Everingham, KI, Koves, TR, and Muoio, DM. "Effects of High and Low Palmitic Acid Diets on Whole Body, Tissue, and Serum Lipids." October 2010.  Link to Item
    • Kien, CL, Bunn, JY, Koves, T, Ilkayeva, O, and Muoio, DM. "Effects of High and Low Palmitic Acid Diets on Fatty Acid Metabolism in Non-Obese Human Subjects." October 2010.  Link to Item
    • Kovalik, J-P, Noland, RC, Ilkayeva, O, and Muoio, DM. "Metabolic crosstalk between human skeletal myocytes and co-cultured adipocytes." June 2008.  Link to Item
    • Bell, JA, Martin, OJ, Reed, MA, Bonen, A, Muoio, DM, and Dohm, GL. "Regulation of lipid deposition in primary myocytes of lean and obese subjects." June 2007.  Link to Item
    • Fitzpatrick, LL, Kovalik, J-P, Buehrer, B, and Muoio, DM. "Lipid loading alters metabolic function of primary human adipocytes grown in culture." June 2007.  Link to Item
    • Bell, JA, Slentz, D, Muoio, DM, and Dohm, GL. "Regulation of FAT/CD36 expression in human skeletal muscle." April 2007.  Link to Item
    • Berggren, JR, Hulver, MW, Tanner, CL, Koves, T, Muoio, DM, and Houmard, JA. "Defects in morbidly obese skeletal muscle lipid metabolism are retained in primary cultures." March 23, 2004.  Link to Item

  • Journal Articles

    • Krycer, JR, Fisher-Wellman, KH, Fazakerley, DJ, Muoio, DM, and James, DE. "Bicarbonate alters cellular responses in respiration assays." Biochemical and biophysical research communications 489, no. 4 (August 2017): 399-403.  Full Text
    • Anderson, KA, Huynh, FK, Fisher-Wellman, K, Stuart, JD, Peterson, BS, Douros, JD, Wagner, GR, Thompson, JW, Madsen, AS, Green, MF, Sivley, RM, Ilkayeva, OR, Stevens, RD, Backos, DS, Capra, JA, Olsen, CA, Campbell, JE, Muoio, DM, Grimsrud, PA, and Hirschey, MD. "SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion." Cell metabolism 25, no. 4 (April 2017): 838-855.e15.  Full Text
    • Muoio, DM. "HDAC3 sets the timer on muscle fuel switching." Nature medicine 23, no. 2 (February 2017): 148-150.  Full Text
    • Huffman, KM, Jessee, R, Andonian, B, Davis, BN, Narowski, R, Huebner, JL, Kraus, VB, McCracken, J, Gilmore, BF, Tune, KN, Campbell, M, Koves, TR, Muoio, DM, Hubal, MJ, and Kraus, WE. "Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability." Arthritis research & therapy 19, no. 1 (January 23, 2017): 12-.  Full Text  Open Access Copy
    • Consitt, LA, Koves, TR, Muoio, DM, Nakazawa, M, Newton, CA, and Houmard, JA. "Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction." Biochemical and biophysical research communications 479, no. 4 (October 2016): 868-874.  Full Text
    • Crown, SB, Kelleher, JK, Rouf, R, Muoio, DM, and Antoniewicz, MR. "Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts." American Journal of Physiology - Heart and Circulatory Physiology 311, no. 4 (October 2016): H881-H891.  Full Text
    • Horton, JL, Martin, OJ, Lai, L, Riley, NM, Richards, AL, Vega, RB, Leone, TC, Pagliarini, DJ, Muoio, DM, Bedi, KC, Margulies, KB, Coon, JJ, and Kelly, DP. "Mitochondrial protein hyperacetylation in the failing heart." JCI insight 2, no. 1 (February 25, 2016).
    • Aubert, G, Martin, OJ, Horton, JL, Lai, L, Vega, RB, Leone, TC, Koves, T, Gardell, SJ, Krüger, M, Hoppel, CL, Lewandowski, ED, Crawford, PA, Muoio, DM, and Kelly, DP. "The Failing Heart Relies on Ketone Bodies as a Fuel." Circulation 133, no. 8 (February 2016): 698-705.  Full Text
    • Davies, MN, Kjalarsdottir, L, Thompson, JW, Dubois, LG, Stevens, RD, Ilkayeva, OR, Brosnan, MJ, Rolph, TP, Grimsrud, PA, and Muoio, DM. "The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins." Cell reports 14, no. 2 (January 2016): 243-254.  Full Text
    • Muoio, DM, and Newgard, CB. "Diabetes: The good in fat." Nature 516, no. 7529 (December 4, 2015): 49-50.  Full Text
    • Kraus, WE, Muoio, DM, Stevens, R, Craig, D, Bain, JR, Grass, E, Haynes, C, Kwee, L, Qin, X, Slentz, DH, Krupp, D, Muehlbauer, M, Hauser, ER, Gregory, SG, Newgard, CB, and Shah, SH. "Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis." PLoS genetics 11, no. 11 (November 5, 2015): e1005553-.  Full Text  Open Access Copy
    • Barrientos, T, Laothamatas, I, Koves, TR, Soderblom, EJ, Bryan, M, Moseley, MA, Muoio, DM, and Andrews, NC. "Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle." EBioMedicine 2, no. 11 (November 2015): 1705-1717.  Full Text
    • Keenan, MM, Liu, B, Tang, X, Wu, J, Cyr, D, Stevens, RD, Ilkayeva, O, Huang, Z, Tollini, LA, Murphy, SK, Lucas, J, Muoio, DM, Kim, SY, and Chi, J-T. "ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate." PLoS genetics 11, no. 10 (October 9, 2015): e1005599-.  Full Text  Open Access Copy
    • Huynh, FK, Muoio, DM, and Hirschey, MD. "SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control." Diabetes 64, no. 9 (September 2015): 3058-3060.  Full Text
    • Kien, CL, Matthews, DE, Poynter, ME, Bunn, JY, Fukagawa, NK, Crain, KI, Ebenstein, DB, Tarleton, EK, Stevens, RD, Koves, TR, and Muoio, DM. "Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation." Journal of lipid research 56, no. 9 (September 2015): 1795-1807.  Full Text
    • Neufer, PD, Bamman, MM, Muoio, DM, Bouchard, C, Cooper, DM, Goodpaster, BH, Booth, FW, Kohrt, WM, Gerszten, RE, Mattson, MP, Hepple, RT, Kraus, WE, Reid, MB, Bodine, SC, Jakicic, JM, Fleg, JL, Williams, JP, Joseph, L, Evans, M, Maruvada, P, Rodgers, M, Roary, M, Boyce, AT, Drugan, JK, Koenig, JI, Ingraham, RH, Krotoski, D, Garcia-Cazarin, M, McGowan, JA, and Laughlin, MR. "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits." Cell metabolism 22, no. 1 (July 2015): 4-11. (Review)  Full Text
    • Ping, P, Gustafsson, ÅB, Bers, DM, Blatter, LA, Cai, H, Jahangir, A, Kelly, D, Muoio, D, O'Rourke, B, Rabinovitch, P, Trayanova, N, Van Eyk, J, Weiss, JN, Wong, R, and Schwartz Longacre, L. "Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative." Circulation research 117, no. 3 (July 2015): 234-238.  Full Text
    • Seiler, SE, Koves, TR, Gooding, JR, Wong, KE, Stevens, RD, Ilkayeva, OR, Wittmann, AH, DeBalsi, KL, Davies, MN, Lindeboom, L, Schrauwen, P, Schrauwen-Hinderling, VB, and Muoio, DM. "Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise." Cell metabolism 22, no. 1 (July 2015): 65-76.  Full Text
    • "Women in Metabolism: Part I." Cell Metabolism 21, no. 5 (May 2015): 654-657.  Full Text
    • Baker, PR, Boyle, KE, Koves, TR, Ilkayeva, OR, Muoio, DM, Houmard, JA, and Friedman, JE. "Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans." Obesity (Silver Spring, Md.) 23, no. 5 (May 2015): 981-988.  Full Text
    • Baker, PR, Boyle, KE, Koves, TR, Ilkayeva, OR, Muoio, DM, Houmard, JA, and Friedman, JE. "Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans." Obesity 23, no. 5 (May 2015): 981-988.  Full Text
    • Wong, KE, Mikus, CR, Slentz, DH, Seiler, SE, DeBalsi, KL, Ilkayeva, OR, Crain, KI, Kinter, MT, Kien, CL, Stevens, RD, and Muoio, DM. "Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction." Diabetes 64, no. 5 (May 2015): 1532-1543.  Full Text
    • Fisher-Wellman, KH, Lin, C-T, Ryan, TE, Reese, LR, Gilliam, LAA, Cathey, BL, Lark, DS, Smith, CD, Muoio, DM, and Neufer, PD. "Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit." The Biochemical journal 467, no. 2 (April 2015): 271-280.  Full Text
    • Li, LO, Grevengoed, TJ, Paul, DS, Ilkayeva, O, Koves, TR, Pascual, F, Newgard, CB, Muoio, DM, and Coleman, RA. "Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis." Diabetes 64, no. 1 (January 2015): 23-35.  Full Text
    • Muoio, DM, and Newgard, CB. "The good in fat." Nature 516, no. 729 (December 4, 2014): 49-50.  Full Text
    • Muoio, DM, and Newgard, CB. "Diabetes: The good in fat." Nature 516, no. 7529 (December 4, 2014): 49-50.  Full Text
    • Muoio, DM, and Newgard, CB. "Diabetes: The good in fat." Nature 516, no. 7529 (December 2014): 49-50.  Full Text
    • Muoio, DM. "Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock." Cell 159, no. 6 (December 2014): 1253-1262.  Full Text
    • Huffman, KM, Koves, TR, Hubal, MJ, Abouassi, H, Beri, N, Bateman, LA, Stevens, RD, Ilkayeva, OR, Hoffman, EP, Muoio, DM, and Kraus, WE. "Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness." Diabetologia 57, no. 11 (November 2014): 2282-2295.  Full Text
    • Lai, L, Leone, TC, Keller, MP, Martin, OJ, Broman, AT, Nigro, J, Kapoor, K, Koves, TR, Stevens, R, Ilkayeva, OR, Vega, RB, Attie, AD, Muoio, DM, and Kelly, DP. "Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach." Circulation. Heart failure 7, no. 6 (November 2014): 1022-1031.  Full Text
    • Lindeboom, L, Nabuurs, CI, Hoeks, J, Brouwers, B, Phielix, E, Kooi, ME, Hesselink, MKC, Wildberger, JE, Stevens, RD, Koves, T, Muoio, DM, Schrauwen, P, and Schrauwen-Hinderling, VB. "Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection." The Journal of clinical investigation 124, no. 11 (November 2014): 4915-4925.  Full Text
    • Soni, MS, Rabaglia, ME, Bhatnagar, S, Shang, J, Ilkayeva, O, Mynatt, R, Zhou, Y-P, Schadt, EE, Thornberry, NA, Muoio, DM, Keller, MP, and Attie, AD. "Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion." Diabetes 63, no. 11 (November 2014): 3805-3814.  Full Text
    • Ussher, JR, Keung, W, Fillmore, N, Koves, TR, Mori, J, Zhang, L, Lopaschuk, DG, Ilkayeva, OR, Wagg, CS, Jaswal, JS, Muoio, DM, and Lopaschuk, GD. "Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice." The Journal of pharmacology and experimental therapeutics 349, no. 3 (June 2014): 487-496.  Full Text
    • Seiler, SE, Martin, OJ, Noland, RC, Slentz, DH, DeBalsi, KL, Ilkayeva, OR, An, J, Newgard, CB, Koves, TR, and Muoio, DM. "Obesity and lipid stress inhibit carnitine acetyltransferase activity." J Lipid Res 55, no. 4 (April 2014): 635-644.  Full Text  Link to Item
    • DeBalsi, KL, Wong, KE, Koves, TR, Slentz, DH, Seiler, SE, Wittmann, AH, Ilkayeva, OR, Stevens, RD, Perry, CGR, Lark, DS, Hui, ST, Szweda, L, Neufer, PD, and Muoio, DM. "Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle." The Journal of biological chemistry 289, no. 12 (March 2014): 8106-8120.  Full Text
    • Kien, CL, Bunn, JY, Stevens, R, Bain, J, Ikayeva, O, Crain, K, Koves, TR, and Muoio, DM. "Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans." The American journal of clinical nutrition 99, no. 3 (March 2014): 436-445.  Full Text
    • Kien, CL, Bunn, JY, Stevens, R, Bain, J, Ikayeva, O, Crain, K, Koves, TR, and Muoio, DM. "Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans." American Journal of Clinical Nutrition 99, no. 3 (March 1, 2014): 436-445.  Full Text
    • Martin, OJ, Lai, L, Soundarapandian, MM, Leone, TC, Zorzano, A, Keller, MP, Attie, AD, Muoio, DM, and Kelly, DP. "A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth." Circ Res 114, no. 4 (February 14, 2014): 626-636.  Full Text  Link to Item
    • Martin, OJ, Lai, L, Soundarapandian, MM, Leone, TC, Zorzano, A, Keller, MP, Attie, AD, Muoio, DM, and Kelly, DP. "A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth." Circulation Research 114, no. 4 (February 14, 2014): 626-636.  Full Text
    • Huffman, KM, Koves, TR, Hubal, MJ, Abouassi, H, Beri, N, Bateman, LA, Stevens, RD, Ilkayeva, OR, Hoffman, EP, Muoio, DM, and Kraus, WE. "Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness." Diabetologia 57, no. 11 (January 1, 2014): 2282-2295.  Full Text
    • Wendel, AA, Cooper, DE, Ilkayeva, OR, Muoio, DM, and Coleman, RA. "Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation." J Biol Chem 288, no. 38 (September 20, 2013): 27299-27306.  Full Text  Link to Item
    • Wong, KE, Koves, TR, Stevens, RD, Ikayeva, O, Slentz, D, and Muoio, DM. "Increased Muscle Mitochondrial Mass in MCK-PGC1 alpha Transgenic Mice Alters Metabolic Responses to Diet and Exercise Intervention But Does Not Improve Clinically Relevant Outcomes." DIABETES 62 (July 2013): A15-A15.  Link to Item
    • Laurent, G, German, NJ, Saha, AK, de Boer, VCJ, Davies, M, Koves, TR, Dephoure, N, Fischer, F, Boanca, G, Vaitheesvaran, B, Lovitch, SB, Sharpe, AH, Kurland, IJ, Steegborn, C, Gygi, SP, Muoio, DM, Ruderman, NB, and Haigis, MC. "SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase." Mol Cell 50, no. 5 (June 6, 2013): 686-698.  Full Text  Link to Item
    • Kien, CL, Bunn, JY, Poynter, ME, Stevens, R, Bain, J, Ikayeva, O, Fukagawa, NK, Champagne, CM, Crain, KI, Koves, TR, and Muoio, DM. "A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults." Diabetes 62, no. 4 (April 2013): 1054-1063.  Full Text  Link to Item
    • Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood." Am J Clin Nutr 97, no. 4 (April 2013): 689-697.  Full Text  Link to Item
    • Zeisel, SH, Waterland, RA, Ordovás, JM, Muoio, DM, Jia, W, and Fodor, A. "Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research." JPEN J Parenter Enteral Nutr 37, no. 2 (March 2013): 190-200.  Full Text  Link to Item
    • Jackson, KC, Wohlers, LM, Lovering, RM, Schuh, RA, Maher, AC, Bonen, A, Koves, TR, Ilkayeva, O, Thomson, DM, Muoio, DM, and Spangenburg, EE. "Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice." Am J Physiol Regul Integr Comp Physiol 304, no. 3 (February 2013): R206-R217.  Full Text  Link to Item
    • Koves, TR, Sparks, LM, Kovalik, JP, Mosedale, M, Arumugam, R, DeBalsi, KL, Everingham, K, Thorne, L, Phielix, E, Meex, RC, Kien, CL, Hesselink, MKC, Schrauwen, P, and Muoio, DM. "PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans." J Lipid Res 54, no. 2 (February 2013): 522-534.  Full Text  Link to Item
    • Zhu, J, Adli, M, Zou, JY, Verstappen, G, Coyne, M, Zhang, X, Durham, T, Miri, M, Deshpande, V, De Jager, PL, Bennett, DA, Houmard, JA, Muoio, DM, Onder, TT, Camahort, R, Cowan, CA, Meissner, A, Epstein, CB, Shoresh, N, and Bernstein, BE. "Genome-wide chromatin state transitions associated with developmental and environmental cues." Cell 152, no. 3 (January 31, 2013): 642-654.  Full Text  Link to Item
    • Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Erratum: Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood (American Journal of Clinical Nutrition (2013) 97 (689-697))." American Journal of Clinical Nutrition 98, no. 2 (2013): 511--.  Full Text
    • Smith, BK, Perry, CGR, Koves, TR, Wright, DC, Smith, JC, Neufer, PD, Muoio, DM, and Holloway, GP. "Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates." Biochem J 448, no. 1 (November 15, 2012): 13-20.  Full Text  Link to Item
    • Muoio, DM. "Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road." Diabetologia 55, no. 10 (October 2012): 2551-2554.  Full Text  Link to Item
    • Muoio, DM. "Revisiting the connection between intramyocellular lipids and insulin resistance: A long and winding road." Diabetologia 55, no. 10 (October 1, 2012): 2521-2554.  Full Text
    • Muoio, DM, Noland, RC, Kovalik, J-P, Seiler, SE, Davies, MN, DeBalsi, KL, Ilkayeva, OR, Stevens, RD, Kheterpal, I, Zhang, J, Covington, JD, Bajpeyi, S, Ravussin, E, Kraus, W, Koves, TR, and Mynatt, RL. "Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility." Cell Metab 15, no. 5 (May 2, 2012): 764-777.  Full Text  Link to Item
    • Muoio, DM, and Neufer, PD. "Lipid-induced mitochondrial stress and insulin action in muscle." Cell Metab 15, no. 5 (May 2, 2012): 595-605.  Full Text  Link to Item
    • Muoio, DM. "Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road." Diabetologia 55, no. 10 (2012): 2551-2554.  Full Text
    • Watt, MJ, Hoy, AJ, Muoio, DM, and Coleman, RA. "Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments." Am J Physiol Endocrinol Metab 302, no. 1 (January 1, 2012): E1-E3.  Full Text  Link to Item
    • Miranda, DA, Koves, TR, Gross, DA, Chadt, A, Al-Hasani, H, Cline, GW, Schwartz, GJ, Muoio, DM, and Silver, DL. "Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2." J Biol Chem 286, no. 49 (December 9, 2011): 42188-42199.  Full Text  Link to Item
    • Kovalik, J-P, Slentz, D, Stevens, RD, Kraus, WE, Houmard, JA, Nicoll, JB, Lea-Currie, YR, Everingham, K, Kien, CL, Buehrer, BM, and Muoio, DM. "Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system." Diabetes 60, no. 7 (July 2011): 1882-1893.  Full Text  Link to Item
    • Boyle, KE, Canham, JP, Consitt, LA, Zheng, D, Koves, TR, Gavin, TP, Holbert, D, Neufer, PD, Ilkayeva, O, Muoio, DM, and Houmard, JA. "A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals." J Clin Endocrinol Metab 96, no. 3 (March 2011): 775-781.  Full Text  Link to Item
    • Ellis, JM, Mentock, SM, Depetrillo, MA, Koves, TR, Sen, S, Watkins, SM, Muoio, DM, Cline, GW, Taegtmeyer, H, Shulman, GI, Willis, MS, and Coleman, RA. "Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy." Mol Cell Biol 31, no. 6 (March 2011): 1252-1262.  Full Text  Link to Item
    • Kien, CL, Everingham, KI, D Stevens, R, Fukagawa, NK, and Muoio, DM. "Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects." Obesity (Silver Spring) 19, no. 2 (February 2011): 305-311.  Full Text  Link to Item
    • Ussher, JR, Koves, TR, Cadete, VJJ, Zhang, L, Jaswal, JS, Swyrd, SJ, Lopaschuk, DG, Proctor, SD, Keung, W, Muoio, DM, and Lopaschuk, GD. "Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption." Diabetes 59, no. 10 (October 2010): 2453-2464.  Full Text  Link to Item
    • Chen, JL-Y, Merl, D, Peterson, CW, Wu, J, Liu, PY, Yin, H, Muoio, DM, Ayer, DE, West, M, and Chi, J-T. "Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. (Published online)" PLoS Genet 6, no. 9 (September 2, 2010): e1001093-.  Full Text  Open Access Copy  Link to Item
    • Thyfault, JP, Cree, MG, Tapscott, EB, Bell, JA, Koves, TR, Ilkayeva, O, Wolfe, RR, Dohm, GL, and Muoio, DM. "Metabolic profiling of muscle contraction in lean compared with obese rodents." Am J Physiol Regul Integr Comp Physiol 299, no. 3 (September 2010): R926-R934.  Full Text  Link to Item
    • Muoio, DM. "Metabolism and vascular fatty acid transport." N Engl J Med 363, no. 3 (July 15, 2010): 291-293.  Full Text  Link to Item
    • Ellis, JM, Li, LO, Wu, P-C, Koves, TR, Ilkayeva, O, Stevens, RD, Watkins, SM, Muoio, DM, and Coleman, RA. "Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis." Cell Metab 12, no. 1 (July 7, 2010): 53-64.  Full Text  Link to Item
    • Bell, JA, Reed, MA, Consitt, LA, Martin, OJ, Haynie, KR, Hulver, MW, Muoio, DM, and Dohm, GL. "Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression." J Clin Endocrinol Metab 95, no. 7 (July 2010): 3400-3410.  Full Text  Link to Item
    • Consitt, LA, Bell, JA, Koves, TR, Muoio, DM, Hulver, MW, Haynie, KR, Dohm, GL, and Houmard, JA. "Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals." Diabetes 59, no. 6 (June 2010): 1407-1415.  Full Text  Link to Item
    • Koonen, DPY, Sung, MMY, Kao, CKC, Dolinsky, VW, Koves, TR, Ilkayeva, O, Jacobs, RL, Vance, DE, Light, PE, Muoio, DM, Febbraio, M, and Dyck, JRB. "Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance." Diabetes 59, no. 6 (June 2010): 1366-1375.  Full Text  Link to Item
    • Glynn, EL, An, J, Wang, L-P, Ilkayeva, OR, Stevens, RD, Bain, JR, Muehlbauer, MJ, Koves, TR, Summers, SA, Muoio, DM, and Newgard, CB. "Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity." FASEB JOURNAL 24 (April 2010).  Link to Item
    • Spangenburg, EE, Campbell, KM, Wohlers, LM, Maher, AC, Koves, TK, Bonen, A, and Muoio, DM. "Loss of ovarian function alters multiple aspects of lipid metabolism in adipose tissue and skeletal muscle from female mice." FASEB JOURNAL 24 (April 2010).  Link to Item
    • Muoio, DM. "Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?." Biochim Biophys Acta 1801, no. 3 (March 2010): 281-288. (Review)  Full Text  Link to Item
    • Curtis, JM, Grimsrud, PA, Wright, WS, Xu, X, Foncea, RE, Graham, DW, Brestoff, JR, Wiczer, BM, Ilkayeva, O, Cianflone, K, Muoio, DE, Arriaga, EA, and Bernlohr, DA. "Downregulation of adipose glutathione S-tansferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction." Diabetes 59, no. 5 (2010): 1132-1142.  Full Text
    • Bain, JR, Stevens, RD, Wenner, BR, Ilkayeva, O, Muoio, DM, and Newgard, CB. "Metabolomics applied to diabetes research: moving from information to knowledge." Diabetes 58, no. 11 (November 2009): 2429-2443.  Full Text  Link to Item
    • Li, LO, Ellis, JM, Paich, HA, Wang, S, Gong, N, Altshuller, G, Thresher, RJ, Koves, TR, Watkins, SM, Muoio, DM, Cline, GW, Shulman, GI, and Coleman, RA. "Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition." J Biol Chem 284, no. 41 (October 9, 2009): 27816-27826.  Full Text  Link to Item
    • Lum, H, Koves, TR, DeBalsi, KL, Ilkayeva, O, Van Remmen, H, and Muoio, DM. "ALTERATIONS IN MITOCHONDRIAL FUEL METABOLISM AND SURVIVAL WITH REDUCED MANGANESE SUPEROXIDE DISMUTASE (SOD2)." GERONTOLOGIST 49 (October 2009): 25-25.  Link to Item
    • Noland, RC, Koves, TR, Seiler, SE, Lum, H, Lust, RM, Ilkayeva, O, Stevens, RD, Hegardt, FG, and Muoio, DM. "Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control." J Biol Chem 284, no. 34 (August 21, 2009): 22840-22852.  Full Text  Link to Item
    • Ussher, JR, Koves, TR, Jaswal, JS, Zhang, L, Ilkayeva, O, Dyck, JRB, Muoio, DM, and Lopaschuk, GD. "Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase." Diabetes 58, no. 8 (August 2009): 1766-1775.  Full Text  Link to Item
    • Malakauskas, SM, Kourany, WM, Zhang, XY, Lu, D, Stevens, RD, Koves, TR, Hohmeier, HE, Muoio, DM, Newgard, CB, and Le, TH. "Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha." Mol Endocrinol 23, no. 6 (June 2009): 881-892.  Full Text  Link to Item
    • Lien, LF, Haqq, AM, Arlotto, M, Slentz, CA, Muehlbauer, MJ, McMahon, RL, Rochon, J, Gallup, D, Bain, JR, Ilkayeva, O, Wenner, BR, Stevens, RD, Millington, DS, Muoio, DM, Butler, MD, Newgard, CB, and Svetkey, LP. "The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain." OMICS 13, no. 1 (February 2009): 21-35.  Full Text  Link to Item
    • Makowski, L, Noland, RC, Koves, TR, Xing, W, Ilkayeva, OR, Muehlbauer, MJ, Stevens, RD, and Muoio, DM. "Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation." FASEB J 23, no. 2 (February 2009): 586-604.  Full Text  Link to Item
    • Ussher, JR, Koves, TR, Jaswal, JS, Zhang, L, Ilkayeva, O, Dyck, JRB, Muoio, DM, and Lopaschuk, GD. "Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase (Diabetes (2009) 58, (1766-1775))." Diabetes 58, no. 10 (2009): 2425--.
    • Ussher, JER, Koves, TR, Jaswal, JS, Newgard, CB, Dyck, JR, Muoio, DM, and Lopaschuk, GD. "Insulin-Stimulated Glucose Oxidation is Increased in Hearts from High Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase." CIRCULATION 118, no. 18 (October 28, 2008): S539-S539.  Link to Item
    • Muoio, DM, and Newgard, CB. "Fatty acid oxidation and insulin action: when less is more." Diabetes 57, no. 6 (June 2008): 1455-1456.  Full Text  Link to Item
    • Stoltzman, CA, Peterson, CW, Breen, KT, Muoio, DM, Billin, AN, and Ayer, DE. "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression." Proc Natl Acad Sci U S A 105, no. 19 (May 13, 2008): 6912-6917.  Full Text  Link to Item
    • Bell, JA, Reed, MA, Muoio, DM, and Dohm, GL. "Fatty acid transporter expression in human myocytes." FASEB JOURNAL 22 (April 2008).  Link to Item
    • Muoio, DM, and Newgard, CB. "Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes." Nat Rev Mol Cell Biol 9, no. 3 (March 2008): 193-205. (Review)  Full Text  Link to Item
    • Koves, TR, Ussher, JR, Noland, RC, Slentz, D, Mosedale, M, Ilkayeva, O, Bain, J, Stevens, R, Dyck, JRB, Newgard, CB, Lopaschuk, GD, and Muoio, DM. "Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance." Cell Metab 7, no. 1 (January 2008): 45-56.  Full Text  Link to Item
    • MUOIO, D. "Mechanisms of disease : molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes." Nat Rev Mol Cell Biol 9 (2008): 193-205.
    • Muoio, DM, and Koves, TR. "Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease." Appl Physiol Nutr Metab 32, no. 5 (October 2007): 874-883. (Review)  Full Text  Link to Item
    • Muoio, DM. "TXNIP links redox circuitry to glucose control." Cell Metab 5, no. 6 (June 2007): 412-414.  Full Text  Link to Item
    • Power, RA, Hulver, MW, Zhang, JY, Dubois, J, Marchand, RM, Ilkayeva, O, Muoio, DM, and Mynatt, RL. "Carnitine revisited: potential use as adjunctive treatment in diabetes." Diabetologia 50, no. 4 (April 2007): 824-832.  Full Text  Link to Item
    • Thyfault, JP, Cree, MG, Zheng, D, Zwetsloot, JJ, Tapscott, EB, Koves, TR, Ilkayeva, O, Wolfe, RR, Muoio, DM, and Dohm, GL. "Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism." Am J Physiol Cell Physiol 292, no. 2 (February 2007): C729-C739.  Full Text  Link to Item
    • Attie, AD, Glass, CK, Spiegelman, BM, O'Rahilly, S, Tabas, I, Kim, JB, Bernlohr, DA, and Muoio, DM. "Discussion." Novartis Foundation Symposium 286 (2007): 196-199.
    • Attie, AD, Spiegelman, BM, Bernlohr, DA, Shi, Y, Kim, JB, Glass, CK, O'Rahilly, S, Hotamisligil, GS, Li, P, Muoio, DM, Zhang, C-Y, and Kadowaki, T. "Discussion." Novartis Foundation Symposium 286 (2007): 6-12.
    • Daum, G, Reue, K, Spiegelman, BM, Jae, BK, Yang, R, Muoio, DM, Tabas, I, Hotamisligil, GS, and Shi, Y. "Discussion." Novartis Foundation Symposium 286 (2007): 68-71.
    • Muoio, DM, and Koves, TR. "Lipid-induced metabolic dysfunction in skeletal muscle." Novartis Found Symp 286 (2007): 24-38.  Link to Item
    • Saito, M, Spiegelman, BM, Glass, CK, O'Rahilly, S, Muoio, DM, and Shi, Y. "General discussion I." Novartis Foundation Symposium 286 (2007): 162-163.
    • Spiegelman, BM, Hotamisligil, GS, Attie, AD, O'Rahilly, S, Muoio, DM, Bernlohr, DA, Tabas, I, Shi, Y, and Han, X. "Discussion." Novartis Foundation Symposium 286 (2007): 94-98.
    • Spiegelman, BM, Muoio, DM, Black, PN, Hotamisligil, GS, Zhang, C-Y, Kadowaki, T, Bernlohr, DA, Shi, Y, and Attie, AD. "Discussion." Novartis Foundation Symposium 286 (2007): 38-46.
    • Tabas, I, Black, PN, Spiegelman, BM, O'Rahilly, S, Bernlohr, DA, Glass, CK, Muoio, DM, and Attie, AD. "Final discussion: Nutrition, ageing and lipotoxicity." Novartis Foundation Symposium 286 (2007): 200-203.
    • Gaillard, S, Grasfeder, LL, Haeffele, CL, Lobenhofer, EK, Chu, T-M, Wolfinger, R, Kazmin, D, Koves, TR, Muoio, DM, Chang, C-Y, and McDonnell, DP. "Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs." Mol Cell 24, no. 5 (December 8, 2006): 797-803.  Full Text  Link to Item
    • Muoio, DM, and Newgard, CB. "Obesity-related derangements in metabolic regulation." Annu Rev Biochem 75 (2006): 367-401. (Review)  Full Text  Link to Item
    • Hulver, MW, Berggren, JR, Carper, MJ, Miyazaki, M, Ntambi, JM, Hoffman, EP, Thyfault, JP, Stevens, R, Dohm, GL, Houmard, JA, and Muoio, DM. "Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans." Cell Metab 2, no. 4 (October 2005): 251-261.  Full Text  Link to Item
    • Koves, TR, Li, P, An, J, Akimoto, T, Slentz, D, Ilkayeva, O, Dohm, GL, Yan, Z, Newgard, CB, and Muoio, DM. "Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency." J Biol Chem 280, no. 39 (September 30, 2005): 33588-33598.  Full Text  Link to Item
    • Muoio, DM, and Newgard, CB. "Metabolism: A is for adipokine." Nature 436, no. 7049 (July 21, 2005): 337-338.  Full Text  Link to Item
    • Hammond, LE, Neschen, S, Romanelli, AJ, Cline, GW, Ilkayeva, OR, Shulman, GI, Muoio, DM, and Coleman, RA. "Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs." J Biol Chem 280, no. 27 (July 8, 2005): 25629-25636.  Full Text  Link to Item
    • Koves, TR, Noland, RC, Bates, AL, Henes, ST, Muoio, DM, and Cortright, RN. "Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism." Am J Physiol Cell Physiol 288, no. 5 (May 2005): C1074-C1082.  Full Text  Link to Item
    • Berggren, JR, Tanner, CJ, Koves, TR, Muoio, DM, and Houmard, JA. "Glucose uptake in muscle cell cultures from endurance-trained men." Med Sci Sports Exerc 37, no. 4 (April 2005): 579-584.  Link to Item
    • Muoio, DM, and Newgard, CB. "Biomedicine. Insulin resistance takes a trip through the ER." Science 306, no. 5695 (October 15, 2004): 425-426.  Full Text  Link to Item
    • An, J, Muoio, DM, Shiota, M, Fujimoto, Y, Cline, GW, Shulman, GI, Koves, TR, Stevens, R, Millington, D, and Newgard, CB. "Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance." Nat Med 10, no. 3 (March 2004): 268-274.  Full Text  Link to Item
    • Muoio, DM, and Lynis Dohm, G. "Peripheral metabolic actions of leptin." Best Pract Res Clin Endocrinol Metab 16, no. 4 (December 2002): 653-666. (Review)  Link to Item
    • Muoio, DM, MacLean, PS, Lang, DB, Li, S, Houmard, JA, Way, JM, Winegar, DA, Corton, JC, Dohm, GL, and Kraus, WE. "Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta." J Biol Chem 277, no. 29 (July 19, 2002): 26089-26097.  Full Text  Link to Item
    • Kim, J-Y, Koves, TR, Yu, G-S, Gulick, T, Cortright, RN, Dohm, GL, and Muoio, DM. "Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle." Am J Physiol Endocrinol Metab 282, no. 5 (May 2002): E1014-E1022.  Full Text  Link to Item
    • Muoio, DM, Way, JM, Tanner, CJ, Winegar, DA, Kliewer, SA, Houmard, JA, Kraus, WE, and Dohm, GL. "Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells." Diabetes 51, no. 4 (April 2002): 901-909.  Link to Item
    • Kim, J-Y, Koves, TR, Yu, G-S, Gulick, T, Cortright, RN, Dohm, GL, and Muoio, DM. "Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle." American Journal of Physiology - Endocrinology and Metabolism 282, no. 5 45-5 (2002): E1014-E1022.
    • Muoio, DM, Lewin, TM, Wiedmer, P, and Coleman, RA. "Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase." Am J Physiol Endocrinol Metab 279, no. 6 (December 2000): E1366-E1373.  Link to Item
    • Vidal-Puig, AJ, Grujic, D, Zhang, CY, Hagen, T, Boss, O, Ido, Y, Szczepanik, A, Wade, J, Mootha, V, Cortright, R, Muoio, DM, and Lowell, BB. "Energy metabolism in uncoupling protein 3 gene knockout mice." J Biol Chem 275, no. 21 (May 26, 2000): 16258-16266.  Full Text  Link to Item
    • Coleman, RA, Lewin, TM, and Muoio, DM. "Physiological and nutritional regulation of enzymes of triacylglycerol synthesis." Annu Rev Nutr 20 (2000): 77-103. (Review)  Full Text  Link to Item
    • Hackney, AC, Muoio, D, and Meyer, WR. "The effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women." Japanese Journal of Physiology 50, no. 5 (2000): 489-494.  Full Text
    • Muoio, DM, Lewin, TM, Wiedmer, P, and Coleman, RA. "Acyl-CoAs are functionally channeled in liver: Potential role of acyl-CoA synthetase." American Journal of Physiology - Endocrinology and Metabolism 279, no. 6 42-6 (2000): E1366-E1373.
    • Muoio, DM, Dohm, GL, Tapscott, EB, and Coleman, RA. "Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice." Am J Physiol 276, no. 5 Pt 1 (May 1999): E913-E921.  Link to Item
    • Muoio, DM, Dohm, GL, Tapscott, EB, and Coleman, RA. "Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice." AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 276, no. 5 (May 1999): E913-E921.  Link to Item
    • Muoio, DM, Seefeld, K, Witters, LA, and Coleman, RA. "AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target." Biochem J 338 ( Pt 3) (March 15, 1999): 783-791.  Link to Item
    • Muoio, DM, Dohm, GL, Tapscott, EB, and Coleman, RA. "Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice." American Journal of Physiology - Endocrinology and Metabolism 276, no. 5 39-5 (1999): E913-E921.
    • Muoio, DM, Schmalz, P, and Coleman, RA. "Evidence that acyl-CoAs are functionally channeled in liver." FASEB Journal 12, no. 4 (1998): A229-.
    • Muoio, DM, Dohm, GL, Fiedorek, FT, Tapscott, EB, and Coleman, RA. "Leptin directly alters partitioning in skeletal muscle (vol 46, pg 1360, 1997)." DIABETES 46, no. 10 (October 1997): 1663-1663.  Link to Item
    • Muoio, DM, Dohm, GL, Fiedorek, FT, Tapscott, EB, and Coleman, RA. "Leptin directly alters lipid partitioning in skeletal muscle." Diabetes 46, no. 8 (August 1997): 1360-1363.  Link to Item
    • Muoio, DM, Dohm, GL, Fiedorek, FT, Tapscott, EB, and Coleman, RA. "Leptin alters skeletal muscle lipid partitioning: Evidence for a direct role of leptin in a peripheral tissue." AMERICAN JOURNAL OF CLINICAL NUTRITION 66, no. 1 (July 1997): 91-91.  Link to Item
    • Muoio, DM, Dohm, GL, and Coleman, RA. "Glucose-fatty acid substrate competition in isolated soleus muscle." FASEB JOURNAL 11, no. 3 (February 28, 1997): 2163-2163.  Link to Item
    • Cortright, RN, Muoio, DM, and Dohm, GL. "Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasis." Journal of Nutritional Biochemistry 8, no. 5 (1997): 228-245.  Full Text
    • MUOIO, D. "Leptin directly alters lipid partitioning in skeletal muscle." Diabetes 46 (1997): 1360-1363.  Full Text
    • Muoio, DM, Dohm, GL, and Coleman, RA. "Glucose-fatty acid substrate competition in isolated soleus muscle." FASEB Journal 11, no. 3 (1997): A373-.
    • Muoio, DM, Leddy, JJ, Horvath, PJ, Awad, AB, and Pendergast, DR. "Effect of dietary fat on metabolic adjustments to maximal VO2 and endurance in runners." Med Sci Sports Exerc 26, no. 1 (January 1994): 81-88.  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 393: Research Independent Study 2017
  • PHARM 493: Research Independent Study 2017
  • PHARM 494: Research Independent Study 2017
  • PHARM 495: Research Independent Study 2015
• 

  Advising & Mentoring

  • Past and Current trainees 

    Koves, T          Post     2002-06           Faculty, Duke University

    Makowski, L     Post     2004-09           Faculty, University of North Carolina CH

    Kovalik, J.        Post     2005-09           Faculty, Duke-NUS Graduate Medical School Singapore

    Noland, R         Post     2005-11           Faculty, Pennington Biomedical Research Institute.  

    Fitzpatrick, L     Post,    2006-09           Endocrine Fellow, Private Practice

    Lum, H Post,    Post,    2006-10           Geriatrics Fellow, Faculty, U. Texas San Antonio

    Martin, O          Post     2005-07           Research Associate, Burnham Institute Orlando, Florida

    DeBalsi, K.       PhD     2007-13           Project Manager, Metabolon, RTP, NC Carolina

    Seiler, S           PhD     2008-13           Research Scientist, Zenbio Inc., Research Triangle Park, NC

    Davies, M.        Post     2010-14           SB Financial Group, LLC, Morrisville, NC

    Wong, K.          Post     2010-15           Project Manager, Metabolon, RTP, NC

    Kjalarsdottir,L.  Post     2012-14           Director of Research, Genis ehf. Iceland

    Clarissa Tio      Post     2012-14           UTSW, Dallas, Medical Residency Program

    Liu, J                Post     2013-14           Research Scientist, Suzhou University, China

    Natalizio, A.      Post     2013-14           Variant Scientist, LabCorp RTP, NC

    Davidson, M.    Pre       2014-               MSTP (MD/PhD)

    Williams, A.       Post     2015-

    Fisher-Wellman Post     2015-  

     

    UNDERGRADUATE STUDENTS (Faculty Mentor, Honors Thesis)

    Merrie Mosedale, 2005-06        PhD earned at U Cal. Davis

    Megan Ramayia, 2009-10       medical school

    Jeremy Steinman, 2011-12      medical school

    Tian Chen, 2012-13                 medical school

    Freddie Peng, 2012-14             medical school

    Yasminye Pettway, 2016-17     post baccalaureate program

     

    Sponsorship of Mentored Grants

    2005-07                NRSA F32 AR054677, Ola Martin, Ph.D., Regulation and Metabolic Impact of Mitochondrial CD36     in Skeletal Muscle.  Role: Primary Mentor

    2007-09           K99 DK078156, Liza Makowski, Ph.D., Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity.  Role: Primary Mentor

    2007-09           American Heart Association Post-doctoral Award, J.P. Kovalik, M.D., Role of Adipocytes in Mediating Skeletal Muscle Insulin Resistance. Role: Primary Mentor

    2007-09           NRSA F32 DK080609 Robert Noland, Ph.D. Role of Carnitine Acetyltransferase in Regulating Mitochondrial Function and Insulin Action. Role: Primary Mentor

    2010-12           American Heart Association Predoctoral Fellowship, Karen DeBalsi.  Role of TXNIP in regulating redox balance and mitochondrial function in cardiac and skeletal muscle. Role: Primary Mentor.       

    2011-14           NRSA F32 DK093256  Michael Davies, PhD.  Role of Carnitine Acetyltransferase in Combatting Nutrient Stress.  Role: Primary Mentor

    2011-14           NRSA F32 DK094573 Kari Wong, PhD. Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle.  Role: Primary Mentor

    2015-18           NRSA F32DK105922. Ashley Williams, PhD. Mitochondrial Protein Acetylation and Energy Metabolism in Muscle.  Role: Primary Mentor

    2015-18           NRSA F32DK105665-01A1. Kelsey Fisher-Wellman, PhD. Role of Malonylation in Regulating Mitochondrial Function.  Role: Primary Mentor

    2017-2020       NRSA F32HL137398.  Scott Crown, PhD.   Development of multiplex 13C-labeling strategies for metabolic flux analysis.  Role: Primary Mentor

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.