Deborah Marie Muoio | Scholars@Duke

Deborah Marie Muoio
Professor of Medicine

Deb Muoio is a Professor of Medicine, Division of Endocrinology, and Director of Basic Research at the Duke Molecular Physiology Institute. She earned a PhD in Nutritional Biochemistry at the University of North Carolina, Chapel Hill, followed by postdoctoral fellowships at East Carolina and Duke Universities working in the areas of muscle physiology and metabolic disease. Her laboratory studies mechanisms of metabolic control and molecular events that link nutrition and exercise to health outcomes. Her research program features a translational approach that combines basic science and human studies with mass spectrometry-based metabolomics to identify metabolite signatures of mitochondrial dysfunction and cardiometabolic disease. The overarching goal of this work is to guide the development of new lifestyle, nutraceutical and/or pharmacological strategies to maintain mitochondrial and metabolic health.

PhD, University of North Carolina, Chapel Hill, NC

Current Appointments & Affiliations

Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2016
Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2016
Member of Sarah W. Stedman Nutrition and Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2002
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

300 North Duke Street, Durham, NC 27701
Duke Box 104775, Durham, NC 27710
muoio@duke.edu (919) 479-2328
DMPI

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 1999
Duke Appointment History
- Associate Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011 - 2016
- Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011 - 2016
- Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2008 - 2011
- Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2004 - 2011
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2004 - 2008
- Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2004
Leadership & Clinical Positions at Duke
- Director, Basic Science Research
  Duke Molecular Physiology Institute
Recognition
In the News
- JUL 9, 2015 Daily Telegraph
  
  Supplement allows elderly people to exercise more rigorously
- JAN 22, 2015 Scientific American
  
  Commentary: How overeating may contribute to a metabolic ‘traffic jam’
Expertise
Subject Headings
Research
Selected Grants
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2019 - 2024
- Mechanisms of lipid-induced bioenergetic stress in muscle awarded by National Institutes of Health 2010 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells awarded by National Institutes of Health 2017 - 2022
- STIM1 and mitochondrial quality control awarded by National Institutes of Health 2017 - 2022
- AHA Career Development Award awarded by American Heart Association 2018 - 2021
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- Role of cardiac and skeletal muscle ketone oxidation in permitting adaptive mitochondrial remodeling in response to lipid stress awarded by Eli Lilly and Company 2019 - 2021
- Molecular Mechanisms of Taxane-Induced Toxicities in Cardiac and Skeletal Muscle awarded by American Heart Association 2019 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Validation of a novel mass spectrometry-based method for measurement of muscle glucose uptake in mice awarded by Augusta University 2020
- Organic Cations and Mitochondrial Efficiency awarded by East Carolina University 2016 - 2020
- Microbial regulation of host nutrient metabolism awarded by National Institutes of Health 2013 - 2020
- Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2017 - 2020
- 13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis awarded by National Institutes of Health 2017 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Organic Cations and Mitochondrial Efficiency awarded by East Carolina University 2016 - 2018
- Mitochondrial Protein Acetylation and Energy Metabolism in Muscle awarded by National Institutes of Health 2015 - 2018
- Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2017
- Carnitine Acetyltransferase and Metabolic Regulation in the Exocrine Pancreas awarded by National Institutes of Health 2015 - 2017
- Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
- Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides awarded by National Institutes of Health 2013 - 2016
- Iron homeostasis in mammalian muscle awarded by National Institutes of Health 2011 - 2016
- Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
- Mechanisms of Insulin Resistance in Rheumatoid Arthritis awarded by National Institutes of Health 2008 - 2015
- Behavior And Physiology In Aging awarded by National Institutes of Health 1999 - 2015
- Instrumentation for Quantitative Phosphoproteomics and Acetylomics awarded by National Institutes of Health 2014 - 2015
- Exercise Dose-Response Effects in Prediabetes:Responses and Mechanisms awarded by National Institutes of Health 2009 - 2015
- Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle awarded by National Institutes of Health 2011 - 2014
- Role of Carnitine Acetyltansferase in Combatting Nutrient Stress awarded by National Institutes of Health 2011 - 2014
- Mechanisms of Insulin Resistance in Rheumatoid Arthritis awarded by National Institutes of Health 2008 - 2013
- Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance awarded by National Institutes of Health 2006 - 2012
- Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity awarded by National Institutes of Health 2007 - 2010
- Regulation and metabolic impact of mitochondrial CD36 in skeletal muscle awarded by National Institutes of Health 2006 - 2009
- Role of carnitine acetyltransferase in mitochondrial function and insulin action awarded by National Institutes of Health 2007 - 2009
- Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
- Ketone Dysregulation and Muscle Insulin Resistance awarded by National Institutes of Health 2004 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yurdagul, Arif, Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, et al. “Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.” Cell Metab 31, no. 3 (March 3, 2020): 518-533.e10. https://doi.org/10.1016/j.cmet.2020.01.001.
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  - Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.
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  - Bartlett, David B., Cris A. Slentz, Leslie H. Willis, Andrew Hoselton, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, et al. “Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.” Front Immunol 11 (2020): 729. https://doi.org/10.3389/fimmu.2020.00729.
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  - Bruls, Yvonne Mh, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, et al. “Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial.” Ebiomedicine 49 (November 2019): 318–30. https://doi.org/10.1016/j.ebiom.2019.10.017.
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  - Ho, Kim L., Liyan Zhang, Cory Wagg, Rami Al Batran, Keshav Gopal, Jody Levasseur, Teresa Leone, et al. “Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.” Cardiovasc Res 115, no. 11 (September 1, 2019): 1606–16. https://doi.org/10.1093/cvr/cvz045.
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  - Lin, Kevin H., Abigail Xie, Justine C. Rutter, Yeong-Ran Ahn, Julia M. Lloyd-Cowden, Amanda G. Nichols, Ryan S. Soderquist, et al. “Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.” Cell Metab 29, no. 5 (May 7, 2019): 1217-1231.e7. https://doi.org/10.1016/j.cmet.2019.01.011.
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  - Khodabukus, Alastair, Lauran Madden, Neel K. Prabhu, Timothy R. Koves, Christopher P. Jackman, Deborah M. Muoio, and Nenad Bursac. “Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.” Biomaterials 198 (April 2019): 259–69. https://doi.org/10.1016/j.biomaterials.2018.08.058.
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  - Haldeman, Jonathan M., Amanda E. Conway, Michelle E. Arlotto, Dorothy H. Slentz, Deborah M. Muoio, Thomas C. Becker, and Christopher B. Newgard. “Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.” Nucleic Acids Res 47, no. 4 (February 28, 2019): e23. https://doi.org/10.1093/nar/gky1286.
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  - Horton, Julie L., Michael T. Davidson, Clara Kurishima, Rick B. Vega, Jeffery C. Powers, Timothy R. Matsuura, Christopher Petucci, et al. “The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.” Jci Insight 4, no. 4 (February 21, 2019). https://doi.org/10.1172/jci.insight.124079.
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  - Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.
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  - Wang, Yingxue, Bridgette A. Christopher, Kirkland A. Wilson, Deborah Muoio, Robert W. McGarrah, Henri Brunengraber, and Guo-Fang Zhang. “Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.” Am J Physiol Endocrinol Metab 315, no. 4 (October 1, 2018): E622–33. https://doi.org/10.1152/ajpendo.00081.2018.
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  - Fisher-Wellman, Kelsey H., Michael T. Davidson, Tara M. Narowski, Chien-Te Lin, Timothy R. Koves, and Deborah M. Muoio. “Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.” Cell Rep 24, no. 13 (September 25, 2018): 3593-3606.e10. https://doi.org/10.1016/j.celrep.2018.08.091.
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  - An, Jie, Liping Wang, Michael L. Patnode, Vanessa K. Ridaura, Jonathan M. Haldeman, Robert D. Stevens, Olga Ilkayeva, et al. “Physiological mechanisms of sustained fumagillin-induced weight loss.” Jci Insight 3, no. 5 (March 8, 2018). https://doi.org/10.1172/jci.insight.99453.
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  - Stöckli, Jacqueline, Kelsey H. Fisher-Wellman, Rima Chaudhuri, Xiao-Yi Zeng, Daniel J. Fazakerley, Christopher C. Meoli, Kristen C. Thomas, et al. “Metabolomic analysis of insulin resistance across different mouse strains and diets.” J Biol Chem 292, no. 47 (November 24, 2017): 19135–45. https://doi.org/10.1074/jbc.M117.818351.
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  - Krycer, James R., Kelsey H. Fisher-Wellman, Daniel J. Fazakerley, Deborah M. Muoio, and David E. James. “Bicarbonate alters cellular responses in respiration assays.” Biochem Biophys Res Commun 489, no. 4 (August 5, 2017): 399–403. https://doi.org/10.1016/j.bbrc.2017.05.151.
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  - Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.
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  - Muoio, Deborah M. “HDAC3 sets the timer on muscle fuel switching.” Nat Med 23, no. 2 (February 7, 2017): 148–50. https://doi.org/10.1038/nm.4282.
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  - Huffman, Kim M., Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, et al. “Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.” Arthritis Res Ther 19, no. 1 (January 23, 2017): 12. https://doi.org/10.1186/s13075-016-1215-7.
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  - Consitt, Leslie A., Timothy R. Koves, Deborah M. Muoio, Masato Nakazawa, Christopher A. Newton, and Joseph A. Houmard. “Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.” Biochem Biophys Res Commun 479, no. 4 (October 28, 2016): 868–74. https://doi.org/10.1016/j.bbrc.2016.09.116.
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  - Crown, Scott B., Joanne K. Kelleher, Rosanne Rouf, Deborah M. Muoio, and Maciek R. Antoniewicz. “Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.” Am J Physiol Heart Circ Physiol 311, no. 4 (October 1, 2016): H881–91. https://doi.org/10.1152/ajpheart.00428.2016.
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  - Aubert, Gregory, Ola J. Martin, Julie L. Horton, Ling Lai, Rick B. Vega, Teresa C. Leone, Timothy Koves, et al. “The Failing Heart Relies on Ketone Bodies as a Fuel.” Circulation 133, no. 8 (February 23, 2016): 698–705. https://doi.org/10.1161/CIRCULATIONAHA.115.017355.
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  - Horton, Julie L., Ola J. Martin, Ling Lai, Nicholas M. Riley, Alicia L. Richards, Rick B. Vega, Teresa C. Leone, et al. “Mitochondrial protein hyperacetylation in the failing heart.” Jci Insight 2, no. 1 (February 2016). https://doi.org/10.1172/jci.insight.84897.
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  - Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.
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  - Barrientos, Tomasa, Indira Laothamatas, Timothy R. Koves, Erik J. Soderblom, Miles Bryan, M Arthur Moseley, Deborah M. Muoio, and Nancy C. Andrews. “Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.” Ebiomedicine 2, no. 11 (November 2015): 1705–17. https://doi.org/10.1016/j.ebiom.2015.09.041.
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  - Kraus, William E., Deborah M. Muoio, Robert Stevens, Damian Craig, James R. Bain, Elizabeth Grass, Carol Haynes, et al. “Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.” Plos Genet 11, no. 11 (November 2015): e1005553. https://doi.org/10.1371/journal.pgen.1005553.
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  - Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.” Plos Genet 11, no. 10 (October 2015): e1005599. https://doi.org/10.1371/journal.pgen.1005599.
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  - Huynh, Frank K., Deborah M. Muoio, and Matthew D. Hirschey. “SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.” Diabetes 64, no. 9 (September 2015): 3058–60. https://doi.org/10.2337/db15-0709.
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  - Kien, C Lawrence, Dwight E. Matthews, Matthew E. Poynter, Janice Y. Bunn, Naomi K. Fukagawa, Karen I. Crain, David B. Ebenstein, et al. “Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.” J Lipid Res 56, no. 9 (September 2015): 1795–1807. https://doi.org/10.1194/jlr.M060137.
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  - Ping, Peipei, Åsa B. Gustafsson, Don M. Bers, Lothar A. Blatter, Hua Cai, Arshad Jahangir, Daniel Kelly, et al. “Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.” Circ Res 117, no. 3 (July 17, 2015): 234–38. https://doi.org/10.1161/CIRCRESAHA.117.306693.
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  - Neufer, P Darrell, Marcas M. Bamman, Deborah M. Muoio, Claude Bouchard, Dan M. Cooper, Bret H. Goodpaster, Frank W. Booth, et al. “Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.” Cell Metab 22, no. 1 (July 7, 2015): 4–11. https://doi.org/10.1016/j.cmet.2015.05.011.
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  - Seiler, Sarah E., Timothy R. Koves, Jessica R. Gooding, Kari E. Wong, Robert D. Stevens, Olga R. Ilkayeva, April H. Wittmann, et al. “Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.” Cell Metab 22, no. 1 (July 7, 2015): 65–76. https://doi.org/10.1016/j.cmet.2015.06.003.
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  - “Women in metabolism: part I.” Cell Metab 21, no. 5 (May 5, 2015): 654–57. https://doi.org/10.1016/j.cmet.2015.04.017.
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  - Baker, Peter R., Kristen E. Boyle, Timothy R. Koves, Olga R. Ilkayeva, Deborah M. Muoio, Joseph A. Houmard, and Jacob E. Friedman. “Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.” Obesity (Silver Spring) 23, no. 5 (May 2015): 981–88. https://doi.org/10.1002/oby.21046.
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  - Wong, Kari E., Catherine R. Mikus, Dorothy H. Slentz, Sarah E. Seiler, Karen L. DeBalsi, Olga R. Ilkayeva, Karen I. Crain, et al. “Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction.” Diabetes 64, no. 5 (May 2015): 1532–43. https://doi.org/10.2337/db14-0827.
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  - Fisher-Wellman, Kelsey H., Chien-Te Lin, Terence E. Ryan, Lauren R. Reese, Laura A. A. Gilliam, Brook L. Cathey, Daniel S. Lark, Cody D. Smith, Deborah M. Muoio, and P Darrell Neufer. “Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.” Biochem J 467, no. 2 (April 15, 2015): 271–80. https://doi.org/10.1042/BJ20141447.
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  - Baker, P. R., K. E. Boyle, T. R. Koves, O. R. Ilkayeva, D. M. Muoio, J. A. Houmard, and J. E. Friedman. “Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.” Obesity 23, no. 5 (January 1, 2015): 981–88. https://doi.org/10.1002/oby.21046.
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  - Li, Lei O., Trisha J. Grevengoed, David S. Paul, Olga Ilkayeva, Timothy R. Koves, Florencia Pascual, Christopher B. Newgard, Deborah M. Muoio, and Rosalind A. Coleman. “Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.” Diabetes 64, no. 1 (January 2015): 23–35. https://doi.org/10.2337/db13-1070.
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  - Muoio, Deborah M. “Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock.” Cell 159, no. 6 (December 4, 2014): 1253–62. https://doi.org/10.1016/j.cell.2014.11.034.
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  - Muoio, Deborah M., and Christopher B. Newgard. “Diabetes: The good in fat.” Nature 516, no. 7529 (December 4, 2014): 49–50. https://doi.org/10.1038/nature14070.
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  - Huffman, Kim M., Timothy R. Koves, Monica J. Hubal, Hiba Abouassi, Nina Beri, Lori A. Bateman, Robert D. Stevens, et al. “Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.” Diabetologia 57, no. 11 (November 2014): 2282–95. https://doi.org/10.1007/s00125-014-3343-4.
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  - Lai, Ling, Teresa C. Leone, Mark P. Keller, Ola J. Martin, Aimee T. Broman, Jessica Nigro, Kapil Kapoor, et al. “Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.” Circ Heart Fail 7, no. 6 (November 2014): 1022–31. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001469.
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  - Lindeboom, Lucas, Christine I. Nabuurs, Joris Hoeks, Bram Brouwers, Esther Phielix, M Eline Kooi, Matthijs K. C. Hesselink, et al. “Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.” J Clin Invest 124, no. 11 (November 2014): 4915–25. https://doi.org/10.1172/JCI74830.
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  - Soni, Mufaddal S., Mary E. Rabaglia, Sushant Bhatnagar, Jin Shang, Olga Ilkayeva, Randall Mynatt, Yun-Ping Zhou, et al. “Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion.” Diabetes 63, no. 11 (November 2014): 3805–14. https://doi.org/10.2337/db13-1677.
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  - Ussher, John R., Wendy Keung, Natasha Fillmore, Timothy R. Koves, Jun Mori, Liyan Zhang, David G. Lopaschuk, et al. “Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.” J Pharmacol Exp Ther 349, no. 3 (June 2014): 487–96. https://doi.org/10.1124/jpet.114.214197.
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  - Seiler, Sarah E., Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, and Deborah M. Muoio. “Obesity and lipid stress inhibit carnitine acetyltransferase activity.” J Lipid Res 55, no. 4 (April 2014): 635–44. https://doi.org/10.1194/jlr.M043448.
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  - DeBalsi, Karen L., Kari E. Wong, Timothy R. Koves, Dorothy H. Slentz, Sarah E. Seiler, April H. Wittmann, Olga R. Ilkayeva, et al. “Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.” J Biol Chem 289, no. 12 (March 21, 2014): 8106–20. https://doi.org/10.1074/jbc.M113.511535.
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  - Kien, C Lawrence, Janice Y. Bunn, Robert Stevens, James Bain, Olga Ikayeva, Karen Crain, Timothy R. Koves, and Deborah M. Muoio. “Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.” Am J Clin Nutr 99, no. 3 (March 2014): 436–45. https://doi.org/10.3945/ajcn.113.070557.
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  - Martin, Ola J., Ling Lai, Mangala M. Soundarapandian, Teresa C. Leone, Antonio Zorzano, Mark P. Keller, Alan D. Attie, Deborah M. Muoio, and Daniel P. Kelly. “A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.” Circ Res 114, no. 4 (February 14, 2014): 626–36. https://doi.org/10.1161/CIRCRESAHA.114.302562.
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  - Wendel, Angela A., Daniel E. Cooper, Olga R. Ilkayeva, Deborah M. Muoio, and Rosalind A. Coleman. “Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.” J Biol Chem 288, no. 38 (September 20, 2013): 27299–306. https://doi.org/10.1074/jbc.M113.485219.
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  - Kien, C. L., J. Y. Bunn, C. L. Tompkins, J. A. Dumas, K. I. Crain, D. B. Ebenstein, T. R. Koves, and D. M. Muoio. “Erratum: Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood (American Journal of Clinical Nutrition (2013) 97 (689-697)).” American Journal of Clinical Nutrition 98, no. 2 (August 1, 2013): 511. https://doi.org/10.3945/ajcn.113.066282.
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  - Wong, Kari E., Timothy R. Koves, Robert D. Stevens, Olga Ikayeva, Dorothy Slentz, and Deborah M. Muoio. “Increased Muscle Mitochondrial Mass in MCK-PGC1 alpha Transgenic Mice Alters Metabolic Responses to Diet and Exercise Intervention But Does Not Improve Clinically Relevant Outcomes.” Diabetes 62 (July 1, 2013): A15–A15.
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  - Laurent, Gaëlle, Natalie J. German, Asish K. Saha, Vincent C. J. de Boer, Michael Davies, Timothy R. Koves, Noah Dephoure, et al. “SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.” Mol Cell 50, no. 5 (June 6, 2013): 686–98. https://doi.org/10.1016/j.molcel.2013.05.012.
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  - Kien, C Lawrence, Janice Y. Bunn, Connie L. Tompkins, Julie A. Dumas, Karen I. Crain, David B. Ebenstein, Timothy R. Koves, and Deborah M. Muoio. “Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.” Am J Clin Nutr 97, no. 4 (April 2013): 689–97. https://doi.org/10.3945/ajcn.112.051730.
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  - Kien, C Lawrence, Janice Y. Bunn, Matthew E. Poynter, Robert Stevens, James Bain, Olga Ikayeva, Naomi K. Fukagawa, et al. “A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.” Diabetes 62, no. 4 (April 2013): 1054–63. https://doi.org/10.2337/db12-0363.
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  - Zeisel, Steven H., Robert A. Waterland, José M. Ordovás, Deborah M. Muoio, Wei Jia, and Anthony Fodor. “Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.” Jpen J Parenter Enteral Nutr 37, no. 2 (March 2013): 190–200. https://doi.org/10.1177/0148607112462401.
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  - Jackson, Kathryn C., Lindsay M. Wohlers, Richard M. Lovering, Rosemary A. Schuh, Amy C. Maher, Arend Bonen, Timothy R. Koves, et al. “Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.” Am J Physiol Regul Integr Comp Physiol 304, no. 3 (February 2013): R206–17. https://doi.org/10.1152/ajpregu.00428.2012.
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  - Smith, Brennan K., Christopher G. R. Perry, Timothy R. Koves, David C. Wright, Jeffrey C. Smith, P Darrell Neufer, Deborah M. Muoio, and Graham P. Holloway. “Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.” Biochem J 448, no. 1 (November 15, 2012): 13–20. https://doi.org/10.1042/BJ20121110.
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  - Muoio, D. M. “Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road.” Diabetologia 55, no. 10 (October 2012): 2551–54. https://doi.org/10.1007/s00125-012-2597-y.
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  - Muoio, Deborah M., Robert C. Noland, Jean-Paul Kovalik, Sarah E. Seiler, Michael N. Davies, Karen L. DeBalsi, Olga R. Ilkayeva, et al. “Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.” Cell Metab 15, no. 5 (May 2, 2012): 764–77. https://doi.org/10.1016/j.cmet.2012.04.005.
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  - Muoio, Deborah M., and P Darrell Neufer. “Lipid-induced mitochondrial stress and insulin action in muscle.” Cell Metab 15, no. 5 (May 2, 2012): 595–605. https://doi.org/10.1016/j.cmet.2012.04.010.
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  - Glynn, Erin L., Jie An, Li-Ping Wang, Olga R. Ilkayeva, Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, et al. “Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity.” Faseb Journal 26 (April 1, 2012).
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  - Watt, Matthew J., Andrew J. Hoy, Deborah M. Muoio, and Rosalind A. Coleman. “Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments.” Am J Physiol Endocrinol Metab 302, no. 1 (January 1, 2012): E1–3. https://doi.org/10.1152/ajpendo.00418.2011.
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  - Miranda, Diego A., Timothy R. Koves, David A. Gross, Alexandra Chadt, Hadi Al-Hasani, Gary W. Cline, Gary J. Schwartz, Deborah M. Muoio, and David L. Silver. “Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.” J Biol Chem 286, no. 49 (December 9, 2011): 42188–99. https://doi.org/10.1074/jbc.M111.297127.
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  - Kovalik, Jean-Paul, Dorothy Slentz, Robert D. Stevens, William E. Kraus, Joseph A. Houmard, James B. Nicoll, Y Renee Lea-Currie, et al. “Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.” Diabetes 60, no. 7 (July 2011): 1882–93. https://doi.org/10.2337/db10-0427.
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  - Boyle, K. E., J. P. Canham, L. A. Consitt, D. Zheng, T. R. Koves, T. P. Gavin, D. Holbert, et al. “A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.” J Clin Endocrinol Metab 96, no. 3 (March 2011): 775–81. https://doi.org/10.1210/jc.2010-2253.
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  - Ellis, Jessica M., Shannon M. Mentock, Michael A. Depetrillo, Timothy R. Koves, Shiraj Sen, Steven M. Watkins, Deborah M. Muoio, et al. “Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.” Mol Cell Biol 31, no. 6 (March 2011): 1252–62. https://doi.org/10.1128/MCB.01085-10.
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  - Kien, C Lawrence, Karen I. Everingham, Robert D Stevens, Naomi K. Fukagawa, and Deborah M. Muoio. “Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.” Obesity (Silver Spring) 19, no. 2 (February 2011): 305–11. https://doi.org/10.1038/oby.2010.135.
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  - Ussher, John R., Timothy R. Koves, Virgilio J. J. Cadete, Liyan Zhang, Jagdip S. Jaswal, Suzanne J. Swyrd, David G. Lopaschuk, et al. “Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.” Diabetes 59, no. 10 (October 2010): 2453–64. https://doi.org/10.2337/db09-1293.
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  - Chen, Julia Ling-Yu, Daniel Merl, Christopher W. Peterson, Jianli Wu, Patrick Yantyng Liu, Hanwei Yin, Deborah M. Muoio, Don E. Ayer, Mike West, and Jen-Tsan Chi. “Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.” Plos Genet 6, no. 9 (September 2, 2010): e1001093. https://doi.org/10.1371/journal.pgen.1001093.
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  - Thyfault, John P., Melanie G. Cree, Edward B. Tapscott, Jill A. Bell, Timothy R. Koves, Olga Ilkayeva, Robert R. Wolfe, G Lynis Dohm, and Deborah M. Muoio. “Metabolic profiling of muscle contraction in lean compared with obese rodents.” Am J Physiol Regul Integr Comp Physiol 299, no. 3 (September 2010): R926–34. https://doi.org/10.1152/ajpregu.00093.2010.
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  - Muoio, Deborah M. “Metabolism and vascular fatty acid transport.” N Engl J Med 363, no. 3 (July 15, 2010): 291–93. https://doi.org/10.1056/NEJMcibr1005397.
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  - Ellis, Jessica M., Lei O. Li, Pei-Chi Wu, Timothy R. Koves, Olga Ilkayeva, Robert D. Stevens, Steven M. Watkins, Deborah M. Muoio, and Rosalind A. Coleman. “Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.” Cell Metab 12, no. 1 (July 7, 2010): 53–64. https://doi.org/10.1016/j.cmet.2010.05.012.
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  - Bell, Jill A., Melissa A. Reed, Leslie A. Consitt, Ola J. Martin, Kimberly R. Haynie, Matthew W. Hulver, Deborah M. Muoio, and G Lynis Dohm. “Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.” J Clin Endocrinol Metab 95, no. 7 (July 2010): 3400–3410. https://doi.org/10.1210/jc.2009-1596.
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  - Consitt, Leslie A., Jill A. Bell, Timothy R. Koves, Deborah M. Muoio, Matthew W. Hulver, Kimberly R. Haynie, G Lynis Dohm, and Joseph A. Houmard. “Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals.” Diabetes 59, no. 6 (June 2010): 1407–15. https://doi.org/10.2337/db09-1704.
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  - Koonen, Debby P. Y., Miranda M. Y. Sung, Cindy K. C. Kao, Vernon W. Dolinsky, Timothy R. Koves, Olga Ilkayeva, René L. Jacobs, et al. “Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.” Diabetes 59, no. 6 (June 2010): 1366–75. https://doi.org/10.2337/db09-1142.
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  - Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.
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  - Spangenburg, Espen E., Kathryn M. Campbell, Lindsay M. Wohlers, Amy C. Maher, Timothy K. Koves, Arend Bonen, and Deborah M. Muoio. “Loss of ovarian function alters multiple aspects of lipid metabolism in adipose tissue and skeletal muscle from female mice.” Faseb Journal 24 (April 1, 2010).
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  - Muoio, Deborah M. “Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?” Biochim Biophys Acta 1801, no. 3 (March 2010): 281–88. https://doi.org/10.1016/j.bbalip.2009.11.007.
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  - Bain, James R., Robert D. Stevens, Brett R. Wenner, Olga Ilkayeva, Deborah M. Muoio, and Christopher B. Newgard. “Metabolomics applied to diabetes research: moving from information to knowledge.” Diabetes 58, no. 11 (November 2009): 2429–43. https://doi.org/10.2337/db09-0580.
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  - Li, Lei O., Jessica M. Ellis, Heather A. Paich, Shuli Wang, Nan Gong, George Altshuller, Randy J. Thresher, et al. “Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.” J Biol Chem 284, no. 41 (October 9, 2009): 27816–26. https://doi.org/10.1074/jbc.M109.022467.
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  - Lum, H., T. R. Koves, K. L. DeBalsi, O. Ilkayeva, H. Van Remmen, and D. M. Muoio. “ALTERATIONS IN MITOCHONDRIAL FUEL METABOLISM AND SURVIVAL WITH REDUCED MANGANESE SUPEROXIDE DISMUTASE (SOD2).” Gerontologist 49 (October 1, 2009): 25–25.
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  - Noland, Robert C., Timothy R. Koves, Sarah E. Seiler, Helen Lum, Robert M. Lust, Olga Ilkayeva, Robert D. Stevens, Fausto G. Hegardt, and Deborah M. Muoio. “Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.” J Biol Chem 284, no. 34 (August 21, 2009): 22840–52. https://doi.org/10.1074/jbc.M109.032888.
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  - Ussher, John R., Timothy R. Koves, Jagdip S. Jaswal, Liyan Zhang, Olga Ilkayeva, Jason R. B. Dyck, Deborah M. Muoio, and Gary D. Lopaschuk. “Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.” Diabetes 58, no. 8 (August 2009): 1766–75. https://doi.org/10.2337/db09-0011.
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  - Malakauskas, Sandra M., Wissam M. Kourany, Xiao Yin Zhang, Danhong Lu, Robert D. Stevens, Timothy R. Koves, Hans E. Hohmeier, Deborah M. Muoio, Christopher B. Newgard, and Thu H. Le. “Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.” Mol Endocrinol 23, no. 6 (June 2009): 881–92. https://doi.org/10.1210/me.2008-0274.
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  - Lien, Lillian F., Andrea M. Haqq, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, Ross L. McMahon, James Rochon, et al. “The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.” Omics 13, no. 1 (February 2009): 21–35. https://doi.org/10.1089/omi.2008.0035.
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  - Makowski, Liza, Robert C. Noland, Timothy R. Koves, Weibing Xing, Olga R. Ilkayeva, Michael J. Muehlbauer, Robert D. Stevens, and Deborah M. Muoio. “Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.” Faseb J 23, no. 2 (February 2009): 586–604. https://doi.org/10.1096/fj.08-119420.
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  - Ussher, J. R., T. R. Koves, J. S. Jaswal, L. Zhang, O. Ilkayeva, J. R. B. Dyck, D. M. Muoio, and G. D. Lopaschuk. “Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase (Diabetes (2009) 58, (1766-1775)).” Diabetes 58, no. 10 (2009): 2425-.
  - Ussher, John Edward R., Timothy R. Koves, Jagdip S. Jaswal, Christopher B. Newgard, Jason R. Dyck, Deborah M. Muoio, and Gary D. Lopaschuk. “Insulin-Stimulated Glucose Oxidation is Increased in Hearts from High Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase.” Circulation 118, no. 18 (October 28, 2008): S539–S539.
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  - Muoio, Deborah M., and Christopher B. Newgard. “Fatty acid oxidation and insulin action: when less is more.” Diabetes 57, no. 6 (June 2008): 1455–56. https://doi.org/10.2337/db08-0281.
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  - Stoltzman, Carrie A., Christopher W. Peterson, Kevin T. Breen, Deborah M. Muoio, Andrew N. Billin, and Donald E. Ayer. “Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.” Proc Natl Acad Sci U S A 105, no. 19 (May 13, 2008): 6912–17. https://doi.org/10.1073/pnas.0712199105.
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  - Bell, Jill A., Melissa A. Reed, Deborah M. Muoio, and G Lynis Dohm. “Fatty acid transporter expression in human myocytes.” Faseb Journal 22 (April 1, 2008).
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  - Muoio, Deborah M., and Christopher B. Newgard. “Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.” Nat Rev Mol Cell Biol 9, no. 3 (March 2008): 193–205. https://doi.org/10.1038/nrm2327.
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  - Koves, Timothy R., John R. Ussher, Robert C. Noland, Dorothy Slentz, Merrie Mosedale, Olga Ilkayeva, James Bain, et al. “Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.” Cell Metab 7, no. 1 (January 2008): 45–56. https://doi.org/10.1016/j.cmet.2007.10.013.
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  - MUOIO, D. M. “Mechanisms of disease : molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.” Nat Rev Mol Cell Biol 9 (2008): 193–205.
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  - Attie, A. D., C. K. Glass, B. M. Spiegelman, S. O’Rahilly, I. Tabas, J. B. Kim, D. A. Bernlohr, and D. M. Muoio. “Discussion.” Novartis Foundation Symposium 286 (December 1, 2007): 196–99.
  - Daum, G., K. Reue, B. M. Spiegelman, B. K. Jae, R. Yang, D. M. Muoio, I. Tabas, G. S. Hotamisligil, and Y. Shi. “Discussion.” Novartis Foundation Symposium 286 (December 1, 2007): 68–71.
  - Saito, M., B. M. Spiegelman, C. K. Glass, S. O’Rahilly, D. M. Muoio, and Y. Shi. “General discussion I.” Novartis Foundation Symposium 286 (December 1, 2007): 162–63.
  - Spiegelman, B. M., D. M. Muoio, P. N. Black, G. S. Hotamisligil, C. Y. Zhang, T. Kadowaki, D. A. Bernlohr, Y. Shi, and A. D. Attie. “Discussion.” Novartis Foundation Symposium 286 (December 1, 2007): 38–46.
  - Spiegelman, B. M., G. S. Hotamisligil, A. D. Attie, S. O’Rahilly, D. M. Muoio, D. A. Bernlohr, I. Tabas, Y. Shi, and X. Han. “Discussion.” Novartis Foundation Symposium 286 (December 1, 2007): 94–98.
  - Tabas, I., P. N. Black, B. M. Spiegelman, S. O’Rahilly, D. A. Bernlohr, C. K. Glass, D. M. Muoio, and A. D. Attie. “Final discussion: Nutrition, ageing and lipotoxicity.” Novartis Foundation Symposium 286 (December 1, 2007): 200–203.
  - Muoio, Deborah M., and Timothy R. Koves. “Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease.” Appl Physiol Nutr Metab 32, no. 5 (October 2007): 874–83. https://doi.org/10.1139/H07-083.
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  - Muoio, Deborah M. “TXNIP links redox circuitry to glucose control.” Cell Metab 5, no. 6 (June 2007): 412–14. https://doi.org/10.1016/j.cmet.2007.05.011.
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  - Power, R. A., M. W. Hulver, J. Y. Zhang, J. Dubois, R. M. Marchand, O. Ilkayeva, D. M. Muoio, and R. L. Mynatt. “Carnitine revisited: potential use as adjunctive treatment in diabetes.” Diabetologia 50, no. 4 (April 2007): 824–32. https://doi.org/10.1007/s00125-007-0605-4.
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  - Thyfault, John P., Melanie G. Cree, Donghai Zheng, Jennifer J. Zwetsloot, Edward B. Tapscott, Timothy R. Koves, Olga Ilkayeva, Robert R. Wolfe, Deborah M. Muoio, and G Lynis Dohm. “Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.” Am J Physiol Cell Physiol 292, no. 2 (February 2007): C729–39. https://doi.org/10.1152/ajpcell.00311.2006.
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  - Muoio, Deborah M., and Timothy R. Koves. “Lipid-induced metabolic dysfunction in skeletal muscle.” Novartis Found Symp 286 (2007): 24–38. https://doi.org/10.1002/9780470985571.ch4.
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  - Gaillard, Stéphanie, Linda L. Grasfeder, Christiane L. Haeffele, Edward K. Lobenhofer, Tzu-Ming Chu, Russ Wolfinger, Dmitri Kazmin, et al. “Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.” Mol Cell 24, no. 5 (December 8, 2006): 797–803. https://doi.org/10.1016/j.molcel.2006.10.012.
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  - Muoio, Deborah M., and Christopher B. Newgard. “Obesity-related derangements in metabolic regulation.” Annu Rev Biochem 75 (2006): 367–401. https://doi.org/10.1146/annurev.biochem.75.103004.142512.
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  - Hulver, Matthew W., Jason R. Berggren, Michael J. Carper, Makoto Miyazaki, James M. Ntambi, Eric P. Hoffman, John P. Thyfault, et al. “Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.” Cell Metab 2, no. 4 (October 2005): 251–61. https://doi.org/10.1016/j.cmet.2005.09.002.
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  - Koves, Timothy R., Ping Li, Jie An, Takayuki Akimoto, Dorothy Slentz, Olga Ilkayeva, G Lynis Dohm, Zhen Yan, Christopher B. Newgard, and Deborah M. Muoio. “Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.” J Biol Chem 280, no. 39 (September 30, 2005): 33588–98. https://doi.org/10.1074/jbc.M507621200.
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  - Muoio, Deborah M., and Christopher B. Newgard. “Metabolism: A is for adipokine.” Nature 436, no. 7049 (July 21, 2005): 337–38. https://doi.org/10.1038/436337a.
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  - Hammond, Linda E., Susanne Neschen, Anthony J. Romanelli, Gary W. Cline, Olga R. Ilkayeva, Gerald I. Shulman, Deborah M. Muoio, and Rosalind A. Coleman. “Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.” J Biol Chem 280, no. 27 (July 8, 2005): 25629–36. https://doi.org/10.1074/jbc.M503181200.
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  - Koves, Timothy R., Robert C. Noland, Andrew L. Bates, Sarah T. Henes, Deborah M. Muoio, and Ronald N. Cortright. “Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism.” Am J Physiol Cell Physiol 288, no. 5 (May 2005): C1074–82. https://doi.org/10.1152/ajpcell.00391.2004.
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  - Berggren, Jason R., Charles J. Tanner, Timothy R. Koves, Deborah M. Muoio, and Joseph A. Houmard. “Glucose uptake in muscle cell cultures from endurance-trained men.” Med Sci Sports Exerc 37, no. 4 (April 2005): 579–84. https://doi.org/10.1249/01.mss.0000158180.11224.e8.
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  - Muoio, Deborah M., and Christopher B. Newgard. “Biomedicine. Insulin resistance takes a trip through the ER.” Science 306, no. 5695 (October 15, 2004): 425–26. https://doi.org/10.1126/science.1104680.
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  - An, Jie, Deborah M. Muoio, Masakazu Shiota, Yuka Fujimoto, Gary W. Cline, Gerald I. Shulman, Timothy R. Koves, Robert Stevens, David Millington, and Christopher B. Newgard. “Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.” Nat Med 10, no. 3 (March 2004): 268–74. https://doi.org/10.1038/nm995.
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  - Muoio, Deborah M., and G. Lynis Dohm. “Peripheral metabolic actions of leptin.” Best Pract Res Clin Endocrinol Metab 16, no. 4 (December 2002): 653–66. https://doi.org/10.1053/beem.2002.0223.
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  - Muoio, Deborah M., Paul S. MacLean, David B. Lang, Shi Li, Joseph A. Houmard, James M. Way, Deborah A. Winegar, J Christopher Corton, G Lynis Dohm, and William E. Kraus. “Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.” J Biol Chem 277, no. 29 (July 19, 2002): 26089–97. https://doi.org/10.1074/jbc.M203997200.
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  - Kim, Jong-Yeon, Timothy R. Koves, Geng-Sheng Yu, Tod Gulick, Ronald N. Cortright, G Lynis Dohm, and Deborah M. Muoio. “Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle.” Am J Physiol Endocrinol Metab 282, no. 5 (May 2002): E1014–22. https://doi.org/10.1152/ajpendo.00233.2001.
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  - Muoio, Deborah M., James M. Way, Charles J. Tanner, Deborah A. Winegar, Steven A. Kliewer, Joseph A. Houmard, William E. Kraus, and G Lynis Dohm. “Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.” Diabetes 51, no. 4 (April 2002): 901–9. https://doi.org/10.2337/diabetes.51.4.901.
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  - Kim, J. Y., T. R. Koves, G. S. Yu, T. Gulick, R. N. Cortright, G. Lynis Dohm, and D. M. Muoio. “Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle.” American Journal of Physiology Endocrinology and Metabolism 282, no. 5 45-5 (January 1, 2002). https://doi.org/10.1152/ajpendo.00233.2001.
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  - Muoio, D. M., T. M. Lewin, P. Wiedmer, and R. A. Coleman. “Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase.” Am J Physiol Endocrinol Metab 279, no. 6 (December 2000): E1366–73. https://doi.org/10.1152/ajpendo.2000.279.6.E1366.
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  - Hackney, A. C., D. Muoio, and W. R. Meyer. “The Effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women.” Jpn J Physiol 50, no. 5 (October 2000): 489–94. https://doi.org/10.2170/jjphysiol.50.489.
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  - Vidal-Puig, A. J., D. Grujic, C. Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szczepanik, et al. “Energy metabolism in uncoupling protein 3 gene knockout mice.” J Biol Chem 275, no. 21 (May 26, 2000): 16258–66. https://doi.org/10.1074/jbc.M910179199.
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  - Coleman, R. A., T. M. Lewin, and D. M. Muoio. “Physiological and nutritional regulation of enzymes of triacylglycerol synthesis.” Annu Rev Nutr 20 (2000): 77–103. https://doi.org/10.1146/annurev.nutr.20.1.77.
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  - Muoio, D. M., T. M. Lewin, P. Wiedmer, and R. A. Coleman. “Acyl-CoAs are functionally channeled in liver: Potential role of acyl-CoA synthetase.” American Journal of Physiology Endocrinology and Metabolism 279, no. 6 42-6 (January 1, 2000). https://doi.org/10.1152/ajpendo.2000.279.6.e1366.
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  - Muoio, D. M., G. L. Dohm, E. B. Tapscott, and R. A. Coleman. “Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.” Am J Physiol 276, no. 5 (May 1999): E913–21. https://doi.org/10.1152/ajpendo.1999.276.5.E913.
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  - Muoio, D. M., G. L. Dohm, E. B. Tapscott, and R. A. Coleman. “Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.” American Journal of Physiology Endocrinology and Metabolism 276, no. 5 (May 1, 1999): E913–21.
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  - Muoio, D. M., K. Seefeld, L. A. Witters, and R. A. Coleman. “AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.” Biochem J 338 ( Pt 3) (March 15, 1999): 783–91.
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  - Muoio, D. M., G. L. Dohm, E. B. Tapscott, and R. A. Coleman. “Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.” American Journal of Physiology Endocrinology and Metabolism 276, no. 5 39-5 (January 1, 1999). https://doi.org/10.1152/ajpendo.1999.276.5.e913.
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  - Muoio, D. M., P. Schmalz, and R. A. Coleman. “Evidence that acyl-CoAs are functionally channeled in liver.” Faseb Journal 12, no. 4 (1998): A229.
  - Muoio, D. M., G. L. Dohm, and R. A. Coleman. “Glucose-fatty acid substrate competition in isolated soleus muscle.” Faseb Journal 11, no. 3 (December 1, 1997).
  - Muoio, D. M., G. L. Dohm, F. T. Fiedorek, E. B. Tapscott, and R. A. Coleman. “Leptin directly alters partitioning in skeletal muscle (vol 46, pg 1360, 1997).” Diabetes 46, no. 10 (October 1, 1997): 1663–1663.
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  - Muoio, D. M., G. L. Dohm, F. T. Fiedorek, E. B. Tapscott, R. A. Coleman, and G. L. Dohn. “Leptin directly alters lipid partitioning in skeletal muscle.” Diabetes 46, no. 8 (August 1, 1997): 1360–63. https://doi.org/10.2337/diabetes.46.8.1360.
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  - Muoio, D. M., G. L. Dohm, F. T. Fiedorek, E. B. Tapscott, and R. A. Coleman. “Leptin directly alters lipid partitioning in skeletal muscle.” Diabetes 46, no. 8 (August 1997): 1360–63. https://doi.org/10.2337/diab.46.8.1360.
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  - Muoio, D. M., G. L. Dohm, F. T. Fiedorek, E. B. Tapscott, and R. A. Coleman. “Leptin alters skeletal muscle lipid partitioning: Evidence for a direct role of leptin in a peripheral tissue.” American Journal of Clinical Nutrition 66, no. 1 (July 1, 1997): 91–91.
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  - Cortright, R. N., D. M. Muoio, and G. L. Dohm. “Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasis.” Journal of Nutritional Biochemistry 8, no. 5 (May 1, 1997): 228–45. https://doi.org/10.1016/S0955-2863(97)89660-X.
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  - Muoio, D. M., G. L. Dohm, and R. A. Coleman. “Glucose-fatty acid substrate competition in isolated soleus muscle.” Faseb Journal 11, no. 3 (February 28, 1997): 2163–2163.
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  - Muoio, D. M., J. J. Leddy, P. J. Horvath, A. B. Awad, and D. R. Pendergast. “Effect of dietary fat on metabolic adjustments to maximal VO2 and endurance in runners.” Med Sci Sports Exerc 26, no. 1 (January 1994): 81–88.
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- Conference Papers
  - Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “Abstract 3004: Contextual RNAi screen identifies ACLY and ACC1 as mediators of hypoxia-induced apoptosis through metabolic and transcriptional mechanisms.” In Molecular and Cellular Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3004.
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  - Keenan, Melissa M., Beiyu Liu, Jianli Wu, Derek Cyr, Joseph Lucas, Deborah M. Muoio, So Young Kim, and Jen-Tsan Chi. “Abstract PR09: A genome-wide RNAi screen reveals a protective role of decreased lipogenesis under hypoxia.” In Tumor Microenvironment and Metabolic Adaptation. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.chtme14-pr09.
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  - Glynn, Erin L., Jie An, Li-Ping Wang, Olga R. Ilkayeva, Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, et al. “Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity.” In Faseb Journal, Vol. 26, 2012.
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  - Kien, C Lawrence, Janice Y. Bunn, Catherine M. Champagne, Karen I. Everingham, Tim R. Koves, and Deborah M. Muoio. “Effects of High and Low Palmitic Acid Diets on Whole Body, Tissue, and Serum Lipids.” In Obesity, 18:S103–S103. NATURE PUBLISHING GROUP, 2010.
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  - Kien, C. L., J. Y. Bunn, T. Koves, Olga Ilkayeva, and D. M. Muoio. “Effects of High and Low Palmitic Acid Diets on Fatty Acid Metabolism in Non-Obese Human Subjects.” In Obesity, 18:S67–S67. NATURE PUBLISHING GROUP, 2010.
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  - Kovalik, Jean-Paul, Robert C. Noland, Olga Ilkayeva, and Deborah M. Muoio. “Metabolic crosstalk between human skeletal myocytes and co-cultured adipocytes.” In Diabetes, 57:A392–93. AMER DIABETES ASSOC, 2008.
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  - Bell, Jill A., Ola J. Martin, Melissa A. Reed, Arend Bonen, Deborah M. Muoio, and G. L. Dohm. “Regulation of lipid deposition in primary myocytes of lean and obese subjects.” In Diabetes, 56:A99–A99. AMER DIABETES ASSOC, 2007.
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  - Fitzpatrick, Laura L., Jean-Paul Kovalik, Benjamin Buehrer, and Deborah M. Muoio. “Lipid loading alters metabolic function of primary human adipocytes grown in culture.” In Diabetes, 56:A359–A359. AMER DIABETES ASSOC, 2007.
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  - Bell, Jill A., Dorothy Slentz, Deborah M. Muoio, and G Lynis Dohm. “Regulation of FAT/CD36 expression in human skeletal muscle.” In Faseb Journal, 21:A1302–A1302. FEDERATION AMER SOC EXP BIOL, 2007.
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  - Berggren, J. R., M. W. Hulver, C. L. Tanner, T. Koves, D. M. Muoio, and J. A. Houmard. “Defects in morbidly obese skeletal muscle lipid metabolism are retained in primary cultures.” In Faseb Journal, 18:A689–A689. FEDERATION AMER SOC EXP BIOL, 2004.
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Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Past and Current trainees
  
  Koves, T          Post     2002-06           Faculty, Duke University
  
  Makowski, L     Post     2004-09           Faculty, University of North Carolina CH
  
  Kovalik, J.        Post     2005-09           Faculty, Duke-NUS Graduate Medical School Singapore
  
  Noland, R         Post     2005-11           Faculty, Pennington Biomedical Research Institute.
  
  Fitzpatrick, L     Post,    2006-09           Endocrine Fellow, Private Practice
  
  Lum, H Post,    Post,    2006-10           Geriatrics Fellow, Faculty, U. Texas San Antonio
  
  Martin, O          Post     2005-07           Research Associate, Burnham Institute Orlando, Florida
  
  DeBalsi, K.       PhD     2007-13           Project Manager, Metabolon, RTP, NC Carolina
  
  Seiler, S           PhD     2008-13           Research Scientist, Zenbio Inc., Research Triangle Park, NC
  
  Davies, M.        Post     2010-14           SB Financial Group, LLC, Morrisville, NC
  
  Wong, K.          Post     2010-15           Project Manager, Metabolon, RTP, NC
  
  Kjalarsdottir,L. Post     2012-14           Director of Research, Genis ehf. Iceland
  
  Clarissa Tio      Post     2012-14           UTSW, Dallas, Medical Residency Program
  
  Liu, J                Post     2013-14           Research Scientist, Suzhou University, China
  
  Natalizio, A.      Post     2013-14           Variant Scientist, LabCorp RTP, NC
  
  Davidson, M.    Pre       2014-               MSTP (MD/PhD)
  
  Williams, A.       Post     2015-
  
  Fisher-Wellman Post     2015-
  
  UNDERGRADUATE STUDENTS (Faculty Mentor, Honors Thesis)
  
  Merrie Mosedale, 2005-06      PhD earned at U Cal. Davis
  
  Megan Ramayia, 2009-10       medical school
  
  Jeremy Steinman, 2011-12    medical school
  
  Tian Chen, 2012-13                 medical school
  
  Freddie Peng, 2012-14             medical school
  
  Yasminye Pettway, 2016-17     post baccalaureate program
  
  Sponsorship of Mentored Grants
  
  2005-07                NRSA F32 AR054677, Ola Martin, Ph.D., Regulation and Metabolic Impact of Mitochondrial CD36     in Skeletal Muscle. Role: Primary Mentor
  
  2007-09           K99 DK078156, Liza Makowski, Ph.D., Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity. Role: Primary Mentor
  
  2007-09           American Heart Association Post-doctoral Award, J.P. Kovalik, M.D., Role of Adipocytes in Mediating Skeletal Muscle Insulin Resistance. Role: Primary Mentor
  
  2007-09           NRSA F32 DK080609 Robert Noland, Ph.D. Role of Carnitine Acetyltransferase in Regulating Mitochondrial Function and Insulin Action. Role: Primary Mentor
  
  2010-12           American Heart Association Predoctoral Fellowship, Karen DeBalsi. Role of TXNIP in regulating redox balance and mitochondrial function in cardiac and skeletal muscle. Role: Primary Mentor.
  
  2011-14           NRSA F32 DK093256 Michael Davies, PhD. Role of Carnitine Acetyltransferase in Combatting Nutrient Stress. Role: Primary Mentor
  
  2011-14           NRSA F32 DK094573 Kari Wong, PhD. Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle. Role: Primary Mentor
  
  2015-18           NRSA F32DK105922. Ashley Williams, PhD. Mitochondrial Protein Acetylation and Energy Metabolism in Muscle. Role: Primary Mentor
  
  2015-18           NRSA F32DK105665-01A1. Kelsey Fisher-Wellman, PhD. Role of Malonylation in Regulating Mitochondrial Function. Role: Primary Mentor
  
  2017-2020       NRSA F32HL137398. Scott Crown, PhD.   Development of multiplex 13C-labeling strategies for metabolic flux analysis. Role: Primary Mentor

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Education, Training, & Certifications

Duke Appointment History

Leadership & Clinical Positions at Duke

In the News

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Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses

Advising & Mentoring