Research Interests
Metabolic physiology, metabolic disease, diabetes, heart disease, aging, mitochondrial bioenergetics, insulin action, exercise physiology, muscle physiology.
Selected Grants
iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
ResearchCo-Mentor · Awarded by National Institute on Aging · 2024 - 2029Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2010 - 2028Using Bioengineered Human Muscle to Develop Treatments for Juvenile Dermatomyositis
ResearchCollaborator · Awarded by Hartwell Foundation · 2025 - 2028Mitochondrial succinyl CoA management at the intersection of heme and ketone metabolism
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2027Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027Ischemia reperfusion injury protection from high intensity exercise
FellowshipCo-Mentor · Awarded by American Heart Association · 2025 - 2026Microbial regulation of intestinal lipid metabolism and its physiological consequences
ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2021 - 2026Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2026Using bioengineered human muscle to understand mechanisms of juvenile dermatomyositis
ResearchCo-Mentor · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2025 - 2026Ketone Body Metabolism and Integrated Metabolic Homeostasis
ResearchPrincipal Investigator · Awarded by University of Minnesota · 2020 - 2026Duke Center for Advancement of Child Health (CAtCH).
Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment
ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2026Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss
ResearchMentor · Awarded by National Institutes of Health · 2020 - 2025Metabolic inflexibility is related to elevated muscle anaerobic glycolysis
ResearchPrincipal Investigator · Awarded by East Carolina University · 2020 - 2025Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart
ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2021 - 2025Accelerated Metabolic Aging in Rheumatoid Arthritis Immune cells and Skeletal Muscle: A Pilot Study
ResearchSignificant Contributor · Awarded by National Institutes of Health · 2020 - 2024STIM1 and mitochondrial quality control
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2024NCDRC P&F April 2022
ResearchCollaborator · Awarded by Wake Forest University · 2021 - 2023Duke Training Grant in Nephrology
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023Multidisciplinary Heart and Vascular Diseases
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells
ResearchCo-Mentor · Awarded by National Institutes of Health · 2017 - 2023Role of cardiac and skeletal muscle ketone oxidation in permitting adaptive mitochondrial remodeling in response to lipid stress
ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2019 - 2022Validation of a novel mass spectrometry-based method for measurement of muscle glucose uptake in mice
ResearchMentor · Awarded by Augusta University · 2020 - 2022Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022AHA Career Development Award
ResearchMentor · Awarded by American Heart Association · 2018 - 2021Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart
ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2017 - 2021Organic Cations and Mitochondrial Efficiency
ResearchPrincipal Investigator · Awarded by East Carolina University · 2016 - 2021Molecular Mechanisms of Taxane-Induced Toxicities in Cardiac and Skeletal Muscle
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2019 - 2020Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020Microbial regulation of host nutrient metabolism
ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 202013C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer
EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV
ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2018Organic Cations and Mitochondrial Efficiency
ResearchPrincipal Investigator · Awarded by East Carolina University · 2016 - 2018Mitochondrial Protein Acetylation and Energy Metabolism in Muscle
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018Role of Protein Malonylation in Regulating Mitochondrial Function
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017Carnitine Acetyltransferase and Metabolic Regulation in the Exocrine Pancreas
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart
ResearchPrincipal Investigator · Awarded by Sanford-Burnham Medical Research Institute · 2017 - 2017Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides
ResearchCo-Mentor · Awarded by National Institutes of Health · 2013 - 2016Iron homeostasis in mammalian muscle
ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2016Metabolic Regulators of Insulin Secretion and Insulin Resistance
ResearchCo-Mentor · Awarded by National Institutes of Health · 2013 - 2015Mechanisms of Insulin Resistance in Rheumatoid Arthritis
ResearchCo-Mentor · Awarded by National Institutes of Health · 2008 - 2015Behavior And Physiology In Aging
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1999 - 2015Instrumentation for Quantitative Phosphoproteomics and Acetylomics
EquipmentMajor User · Awarded by National Institutes of Health · 2014 - 2015Exercise Dose-Response Effects in Prediabetes:Responses and Mechanisms
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2015Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2014Role of Carnitine Acetyltansferase in Combatting Nutrient Stress
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2014Mechanisms of Insulin Resistance in Rheumatoid Arthritis
ResearchCo-Mentor · Awarded by National Institutes of Health · 2008 - 2013Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2012Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity
ResearchMentor · Awarded by National Institutes of Health · 2007 - 2010Regulation and metabolic impact of mitochondrial CD36 in skeletal muscle
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2009Role of carnitine acetyltransferase in mitochondrial function and insulin action
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009Molecular Genetics of Muscle Specialization
ResearchCo Investigator · Awarded by National Institutes of Health · 2001 - 2009Ketone Dysregulation and Muscle Insulin Resistance
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2007External Relationships
- Aegean Conferences, Inc.
- Cell Metabolism Journal
- Cell Press
- Eli Lilly & Co.
- Pfizer Inc.
- University of Toronto
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.