Timothy Robert Koves | Scholars@Duke

Timothy Robert Koves
Associate Professor in Medicine

My research is focused on 1) understanding metabolic perturbations that occur in subpopulations of skeletal muscle mitochondria in response to a chronic high lipid environment, 2) identifying specific metabolites of lipid-induced mitochondrial stress that contribute to skeletal muscle insulin resistance and type II diabetes, and 3) understanding how mitochondrial adaptations in response to exercise confer protection against lipid-induced mitochondrial dysfunction.

Current Appointments & Affiliations

Associate Professor in Medicine, Medicine, Geriatrics, Medicine 2017
Member of Sarah W. Stedman Nutrition & Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2002

Contact Information

300 North Duke Street, 50-202 / Carmichael Bldg, Durham, NC 27701
Duke Box 104775, Durham, NC 27704
tim.koves@duke.edu (919) 479-2324

Background
Education, Training, & Certifications
- M.B.A., East Carolina University 2006
- Ph.D., East Carolina University 2002
Duke Appointment History
- Assistant Professor in Medicine, Medicine, Geriatrics, Medicine 2008 - 2017
- Assistant Research Professor in Medicine, Medicine, Geriatrics, Medicine 2007 - 2008
- Instructor, Temporary in the Department of Medicine, Medicine, Geriatrics, Medicine 2006 - 2007
Research
Selected Grants
- STIM1 and metabolic flexibility awarded by National Institutes of Health 2017 - 2022
- Microbial regulation of host nutrient metabolism awarded by National Institutes of Health 2013 - 2020
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease awarded by National Institutes of Health 2017 - 2019
- Probing the Role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2017 - 2019
- Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic Function awarded by National Institutes of Health 2010 - 2019
- Circulatory system and integrated muscle tissue for drug and tissue toxicity awarded by National Institutes of Health 2012 - 2018
- Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by Sanford-Burnham Medical Research Institute 2017
- Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance awarded by National Institutes of Health 2006 - 2012
- Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood." April 2013. Link to Item
  - Glynn, EL, An, J, Wang, L-P, Ilkayeva, OR, Stevens, RD, Bain, JR, Muehlbauer, MJ, Koves, TR, Summers, SA, Muoio, DM, and Newgard, CB. "Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity." April 2012. Link to Item
  - Kien, CL, Bunn, JY, Champagne, CM, Everingham, KI, Koves, TR, and Muoio, DM. "Effects of High and Low Palmitic Acid Diets on Whole Body, Tissue, and Serum Lipids." October 2010. Link to Item
- Journal Articles
  - Fisher-Wellman, KH, Davidson, MT, Narowski, TM, Lin, C-T, Koves, TR, and Muoio, DM. "Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes." Cell Reports 24, no. 13 (September 2018): 3593-3606.e10. Full Text
  - Davis, BNJ, Santoso, JW, Walker, MJ, Cheng, CS, Koves, TR, Kraus, WE, and Truskey, GA. "Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity." Tissue Engineering. Part C, Methods 23, no. 4 (April 2017): 189-199. Full Text
  - Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of Biological Chemistry 292, no. 11 (March 2017): 4651-4662. Full Text
  - Huffman, KM, Jessee, R, Andonian, B, Davis, BN, Narowski, R, Huebner, JL, Kraus, VB, McCracken, J, Gilmore, BF, Tune, KN, Campbell, M, Koves, TR, Muoio, DM, Hubal, MJ, and Kraus, WE. "Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability." Arthritis Research & Therapy 19, no. 1 (January 23, 2017): 12-null. Full Text Open Access Copy
  - Consitt, LA, Koves, TR, Muoio, DM, Nakazawa, M, Newton, CA, and Houmard, JA. "Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction." Biochemical and biophysical research communications 479, no. 4 (October 2016): 868-874. Full Text
  - Aubert, G, Martin, OJ, Horton, JL, Lai, L, Vega, RB, Leone, TC, Koves, T, Gardell, SJ, Krüger, M, Hoppel, CL, Lewandowski, ED, Crawford, PA, Muoio, DM, and Kelly, DP. "The Failing Heart Relies on Ketone Bodies as a Fuel." Circulation 133, no. 8 (February 2016): 698-705. Full Text
  - Barrientos, T, Laothamatas, I, Koves, TR, Soderblom, EJ, Bryan, M, Moseley, MA, Muoio, DM, and Andrews, NC. "Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle." Ebiomedicine 2, no. 11 (November 2015): 1705-1717. Full Text
  - Kien, CL, Matthews, DE, Poynter, ME, Bunn, JY, Fukagawa, NK, Crain, KI, Ebenstein, DB, Tarleton, EK, Stevens, RD, Koves, TR, and Muoio, DM. "Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation." Journal of Lipid Research 56, no. 9 (September 2015): 1795-1807. Full Text
  - Seiler, SE, Koves, TR, Gooding, JR, Wong, KE, Stevens, RD, Ilkayeva, OR, Wittmann, AH, DeBalsi, KL, Davies, MN, Lindeboom, L, Schrauwen, P, Schrauwen-Hinderling, VB, and Muoio, DM. "Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise." Cell Metabolism 22, no. 1 (July 2015): 65-76. Full Text
  - Baker, PR, Boyle, KE, Koves, TR, Ilkayeva, OR, Muoio, DM, Houmard, JA, and Friedman, JE. "Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans." Obesity (Silver Spring, Md.) 23, no. 5 (May 2015): 981-988. Full Text
  - Baker, PR, Boyle, KE, Koves, TR, Ilkayeva, OR, Muoio, DM, Houmard, JA, and Friedman, JE. "Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans." Obesity 23, no. 5 (May 2015): 981-988. Full Text
  - Li, LO, Grevengoed, TJ, Paul, DS, Ilkayeva, O, Koves, TR, Pascual, F, Newgard, CB, Muoio, DM, and Coleman, RA. "Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis." Diabetes 64, no. 1 (January 2015): 23-35. Full Text
  - Huffman, KM, Koves, TR, Hubal, MJ, Abouassi, H, Beri, N, Bateman, LA, Stevens, RD, Ilkayeva, OR, Hoffman, EP, Muoio, DM, and Kraus, WE. "Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness." Diabetologia 57, no. 11 (November 2014): 2282-2295. Full Text
  - Lai, L, Leone, TC, Keller, MP, Martin, OJ, Broman, AT, Nigro, J, Kapoor, K, Koves, TR, Stevens, R, Ilkayeva, OR, Vega, RB, Attie, AD, Muoio, DM, and Kelly, DP. "Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach." Circulation. Heart Failure 7, no. 6 (November 2014): 1022-1031. Full Text
  - Lindeboom, L, Nabuurs, CI, Hoeks, J, Brouwers, B, Phielix, E, Kooi, ME, Hesselink, MKC, Wildberger, JE, Stevens, RD, Koves, T, Muoio, DM, Schrauwen, P, and Schrauwen-Hinderling, VB. "Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection." The Journal of Clinical Investigation 124, no. 11 (November 2014): 4915-4925. Full Text
  - Tio, MCYO, Koves, TR, Mikus, C, Kien, CL, and Muoio, DM. "A Transcriptomic Analysis of Responses to Overnight Fasting and Refeeding in the Human Skeletal Muscle." ENDOCRINE REVIEWS 35, no. 3 (June 2014). Link to Item
  - Ussher, JR, Keung, W, Fillmore, N, Koves, TR, Mori, J, Zhang, L, Lopaschuk, DG, Ilkayeva, OR, Wagg, CS, Jaswal, JS, Muoio, DM, and Lopaschuk, GD. "Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice." The Journal of Pharmacology and Experimental Therapeutics 349, no. 3 (June 2014): 487-496. Full Text
  - Seiler, SE, Martin, OJ, Noland, RC, Slentz, DH, DeBalsi, KL, Ilkayeva, OR, An, J, Newgard, CB, Koves, TR, and Muoio, DM. "Obesity and lipid stress inhibit carnitine acetyltransferase activity." Journal of Lipid Research 55, no. 4 (April 2014): 635-644. Full Text
  - DeBalsi, KL, Wong, KE, Koves, TR, Slentz, DH, Seiler, SE, Wittmann, AH, Ilkayeva, OR, Stevens, RD, Perry, CGR, Lark, DS, Hui, ST, Szweda, L, Neufer, PD, and Muoio, DM. "Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle." The Journal of Biological Chemistry 289, no. 12 (March 2014): 8106-8120. Full Text
  - Kien, CL, Bunn, JY, Stevens, R, Bain, J, Ikayeva, O, Crain, K, Koves, TR, and Muoio, DM. "Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans." The American journal of clinical nutrition 99, no. 3 (March 2014): 436-445. Full Text
  - Kien, CL, Bunn, JY, Stevens, R, Bain, J, Ikayeva, O, Crain, K, Koves, TR, and Muoio, DM. "Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans." American Journal of Clinical Nutrition 99, no. 3 (March 1, 2014): 436-445. Full Text
  - Huffman, KM, Koves, TR, Hubal, MJ, Abouassi, H, Beri, N, Bateman, LA, Stevens, RD, Ilkayeva, OR, Hoffman, EP, Muoio, DM, and Kraus, WE. "Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness." Diabetologia 57, no. 11 (January 1, 2014): 2282-2295. Full Text
  - Huynh, FK, Green, MF, Koves, TR, and Hirschey, MD. "Measurement of fatty acid oxidation rates in animal tissues and cell lines." Methods in Enzymology 542 (January 2014): 391-405. Full Text
  - Wong, KE, Koves, TR, Stevens, RD, Ikayeva, O, Slentz, D, and Muoio, DM. "Increased Muscle Mitochondrial Mass in MCK-PGC1 alpha Transgenic Mice Alters Metabolic Responses to Diet and Exercise Intervention But Does Not Improve Clinically Relevant Outcomes." DIABETES 62 (July 2013): A15-A15. Link to Item
  - Laurent, G, German, NJ, Saha, AK, de Boer, VCJ, Davies, M, Koves, TR, Dephoure, N, Fischer, F, Boanca, G, Vaitheesvaran, B, Lovitch, SB, Sharpe, AH, Kurland, IJ, Steegborn, C, Gygi, SP, Muoio, DM, Ruderman, NB, and Haigis, MC. "SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase." Molecular Cell 50, no. 5 (June 2013): 686-698. Full Text
  - Kien, CL, Bunn, JY, Poynter, ME, Stevens, R, Bain, J, Ikayeva, O, Fukagawa, NK, Champagne, CM, Crain, KI, Koves, TR, and Muoio, DM. "A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults." Diabetes 62, no. 4 (April 2013): 1054-1063. Full Text
  - Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood." The American Journal of Clinical Nutrition 97, no. 4 (April 2013): 689-697. Full Text
  - Jackson, KC, Wohlers, LM, Lovering, RM, Schuh, RA, Maher, AC, Bonen, A, Koves, TR, Ilkayeva, O, Thomson, DM, Muoio, DM, and Spangenburg, EE. "Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 304, no. 3 (February 2013): R206-R217. Full Text
  - Koves, TR, Sparks, LM, Kovalik, JP, Mosedale, M, Arumugam, R, DeBalsi, KL, Everingham, K, Thorne, L, Phielix, E, Meex, RC, Kien, CL, Hesselink, MKC, Schrauwen, P, and Muoio, DM. "PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans." Journal of Lipid Research 54, no. 2 (February 2013): 522-534. Full Text
  - Kien, CL, Bunn, JY, Tompkins, CL, Dumas, JA, Crain, KI, Ebenstein, DB, Koves, TR, and Muoio, DM. "Erratum: Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood (American Journal of Clinical Nutrition (2013) 97 (689-697))." American Journal of Clinical Nutrition 98, no. 2 (2013): 511--. Full Text
  - Truskey, GA, Achneck, HE, Bursac, N, Chan, H, Cheng, CS, Fernandez, C, Hong, S, Jung, Y, Koves, T, Kraus, WE, Leong, K, Madden, L, Reichert, WM, and Zhao, X. "Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing." Stem Cell Research & Therapy 4 Suppl 1 (January 2013): S10-null. (Review) Full Text
  - Smith, BK, Perry, CGR, Koves, TR, Wright, DC, Smith, JC, Neufer, PD, Muoio, DM, and Holloway, GP. "Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates." The Biochemical Journal 448, no. 1 (November 2012): 13-20. Full Text
  - Kien, CL, Bunn, JY, Poynter, ME, Stevens, R, Bain, J, Ikayeva, O, Fukagawa, NK, Champagne, CM, Crain, K, Koves, TR, and Muoio, DM. "Diet Oleic Acid (OA) Improves Metabolic Risk Factors in Young Adults: Lipidomic Analysis of Sexually Dimorphic Responsiveness." DIABETES 61 (June 1, 2012). Link to Item
  - Muoio, DM, Noland, RC, Kovalik, J-P, Seiler, SE, Davies, MN, DeBalsi, KL, Ilkayeva, OR, Stevens, RD, Kheterpal, I, Zhang, J, Covington, JD, Bajpeyi, S, Ravussin, E, Kraus, W, Koves, TR, and Mynatt, RL. "Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility." Cell Metab 15, no. 5 (May 2, 2012): 764-777. Full Text Link to Item
  - Miranda, DA, Koves, TR, Gross, DA, Chadt, A, Al-Hasani, H, Cline, GW, Schwartz, GJ, Muoio, DM, and Silver, DL. "Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2." The Journal of Biological Chemistry 286, no. 49 (December 2011): 42188-42199. Full Text
  - Boyle, KE, Canham, JP, Consitt, LA, Zheng, D, Koves, TR, Gavin, TP, Holbert, D, Neufer, PD, Ilkayeva, O, Muoio, DM, and Houmard, JA. "A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals." J Clin Endocrinol Metab 96, no. 3 (March 2011): 775-781. Full Text Link to Item
  - Ellis, JM, Mentock, SM, Depetrillo, MA, Koves, TR, Sen, S, Watkins, SM, Muoio, DM, Cline, GW, Taegtmeyer, H, Shulman, GI, Willis, MS, and Coleman, RA. "Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy." Molecular and Cellular Biology 31, no. 6 (March 2011): 1252-1262. Full Text
  - Ussher, JR, Koves, TR, Cadete, VJJ, Zhang, L, Jaswal, JS, Swyrd, SJ, Lopaschuk, DG, Proctor, SD, Keung, W, Muoio, DM, and Lopaschuk, GD. "Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption." Diabetes 59, no. 10 (October 2010): 2453-2464. Full Text
  - Thyfault, JP, Cree, MG, Tapscott, EB, Bell, JA, Koves, TR, Ilkayeva, O, Wolfe, RR, Dohm, GL, and Muoio, DM. "Metabolic profiling of muscle contraction in lean compared with obese rodents." Am J Physiol Regul Integr Comp Physiol 299, no. 3 (September 2010): R926-R934. Full Text Link to Item
  - Ellis, JM, Li, LO, Wu, P-C, Koves, TR, Ilkayeva, O, Stevens, RD, Watkins, SM, Muoio, DM, and Coleman, RA. "Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis." Cell Metab 12, no. 1 (July 7, 2010): 53-64. Full Text Link to Item
  - Consitt, LA, Bell, JA, Koves, TR, Muoio, DM, Hulver, MW, Haynie, KR, Dohm, GL, and Houmard, JA. "Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals." Diabetes 59, no. 6 (June 2010): 1407-1415. Full Text Link to Item
  - Koonen, DPY, Sung, MMY, Kao, CKC, Dolinsky, VW, Koves, TR, Ilkayeva, O, Jacobs, RL, Vance, DE, Light, PE, Muoio, DM, Febbraio, M, and Dyck, JRB. "Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance." Diabetes 59, no. 6 (June 2010): 1366-1375. Full Text Link to Item
  - Glynn, EL, An, J, Wang, L-P, Ilkayeva, OR, Stevens, RD, Bain, JR, Muehlbauer, MJ, Koves, TR, Summers, SA, Muoio, DM, and Newgard, CB. "Caloric restriction, aerobic exercise or a combination improves metabolic profiles following diet-induced obesity." FASEB JOURNAL 24 (April 2010). Link to Item
  - Li, LO, Ellis, JM, Paich, HA, Wang, S, Gong, N, Altshuller, G, Thresher, RJ, Koves, TR, Watkins, SM, Muoio, DM, Cline, GW, Shulman, GI, and Coleman, RA. "Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition." The Journal of Biological Chemistry 284, no. 41 (October 2009): 27816-27826. Full Text
  - Lum, H, Koves, TR, DeBalsi, KL, Ilkayeva, O, Van Remmen, H, and Muoio, DM. "ALTERATIONS IN MITOCHONDRIAL FUEL METABOLISM AND SURVIVAL WITH REDUCED MANGANESE SUPEROXIDE DISMUTASE (SOD2)." GERONTOLOGIST 49 (October 2009): 25-25. Link to Item
  - Noland, RC, Koves, TR, Seiler, SE, Lum, H, Lust, RM, Ilkayeva, O, Stevens, RD, Hegardt, FG, and Muoio, DM. "Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control." J Biol Chem 284, no. 34 (August 21, 2009): 22840-22852. Full Text Link to Item
  - Ussher, JR, Koves, TR, Jaswal, JS, Zhang, L, Ilkayeva, O, Dyck, JRB, Muoio, DM, and Lopaschuk, GD. "Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase." Diabetes 58, no. 8 (August 2009): 1766-1775. Full Text Link to Item
  - Malakauskas, SM, Kourany, WM, Zhang, XY, Lu, D, Stevens, RD, Koves, TR, Hohmeier, HE, Muoio, DM, Newgard, CB, and Le, TH. "Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha." Mol Endocrinol 23, no. 6 (June 2009): 881-892. Full Text Link to Item
  - Makowski, L, Noland, RC, Koves, TR, Xing, W, Ilkayeva, OR, Muehlbauer, MJ, Stevens, RD, and Muoio, DM. "Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 23, no. 2 (February 2009): 586-604. Full Text
  - Ussher, JR, Koves, TR, Jaswal, JS, Zhang, L, Ilkayeva, O, Dyck, JRB, Muoio, DM, and Lopaschuk, GD. "Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase (Diabetes (2009) 58, (1766-1775))." Diabetes 58, no. 10 (2009): 2425--.
  - Ussher, JER, Koves, TR, Jaswal, JS, Newgard, CB, Dyck, JR, Muoio, DM, and Lopaschuk, GD. "Insulin-Stimulated Glucose Oxidation is Increased in Hearts from High Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase." CIRCULATION 118, no. 18 (October 28, 2008): S539-S539. Link to Item
  - Koves, TR, Ussher, JR, Noland, RC, Slentz, D, Mosedale, M, Ilkayeva, O, Bain, J, Stevens, R, Dyck, JRB, Newgard, CB, Lopaschuk, GD, and Muoio, DM. "Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance." Cell Metabolism 7, no. 1 (January 2008): 45-56. Full Text
  - Muoio, DM, and Koves, TR. "Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease." Appl Physiol Nutr Metab 32, no. 5 (October 2007): 874-883. (Review) Full Text Link to Item
  - Thyfault, JP, Cree, MG, Zheng, D, Zwetsloot, JJ, Tapscott, EB, Koves, TR, Ilkayeva, O, Wolfe, RR, Muoio, DM, and Dohm, GL. "Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism." American Journal of Physiology. Cell Physiology 292, no. 2 (February 2007): C729-C739. Full Text
  - Muoio, DM, and Koves, TR. "Lipid-induced metabolic dysfunction in skeletal muscle." Novartis Found Symp 286 (2007): 24-38. Link to Item
  - Gaillard, S, Grasfeder, LL, Haeffele, CL, Lobenhofer, EK, Chu, T-M, Wolfinger, R, Kazmin, D, Koves, TR, Muoio, DM, Chang, C-Y, and McDonnell, DP. "Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs." Mol Cell 24, no. 5 (December 8, 2006): 797-803. Full Text Link to Item
  - Koves, TR, Li, P, An, J, Akimoto, T, Slentz, D, Ilkayeva, O, Dohm, GL, Yan, Z, Newgard, CB, and Muoio, DM. "Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency." The Journal of Biological Chemistry 280, no. 39 (September 2005): 33588-33598. Full Text
  - Koves, TR, Noland, RC, Bates, AL, Henes, ST, Muoio, DM, and Cortright, RN. "Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism." American Journal of Physiology. Cell Physiology 288, no. 5 (May 2005): C1074-C1082. Full Text
  - Berggren, JR, Tanner, CJ, Koves, TR, Muoio, DM, and Houmard, JA. "Glucose uptake in muscle cell cultures from endurance-trained men." Med Sci Sports Exerc 37, no. 4 (April 2005): 579-584. Link to Item
  - An, J, Muoio, DM, Shiota, M, Fujimoto, Y, Cline, GW, Shulman, GI, Koves, TR, Stevens, R, Millington, D, and Newgard, CB. "Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance." Nature Medicine 10, no. 3 (March 2004): 268-274. Full Text
  - Sizemore, GM, Co, C, Koves, TR, Martin, TJ, and Smith, JE. "Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates." Psychopharmacology (Berl) 171, no. 4 (February 2004): 413-420. Full Text Link to Item
  - Fluckey, JD, Cortright, RN, Tapscott, E, Koves, T, Smith, L, Pohnert, S, and Dohm, GL. "Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats." American Journal of Physiology - Endocrinology and Metabolism 286, no. 5 49-5 (2004): E753-E758. Full Text
  - Smith, JE, Koves, TR, and Co, C. "Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration." Neuroscience 117, no. 2 (January 2003): 461-475. Full Text
  - Kim, J-Y, Koves, TR, Yu, G-S, Gulick, T, Cortright, RN, Dohm, GL, and Muoio, DM. "Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle." Am J Physiol Endocrinol Metab 282, no. 5 (May 2002): E1014-E1022. Full Text Link to Item
  - Koves, TR, Noland, RC, Bennett, JM, and Cortright, RN. "Increased sensitivity to malonyl-CoA in intermyofibrillar but not subsarcolemmal skeletal muscle mitochondria after exercise training." FASEB JOURNAL 16, no. 4 (March 20, 2002): A31-A31. Link to Item
  - Noland, RC, Koves, TR, Bennett, JM, Cortright, RN, and Lust, RM. "Mitochondrial fatty acid oxidative capacity is not significantly altered following exercise training in rat heart." FASEB JOURNAL 16, no. 4 (March 20, 2002): A34-A34. Link to Item
  - Kim, J-Y, Koves, TR, Yu, G-S, Gulick, T, Cortright, RN, Dohm, GL, and Muoio, DM. "Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle." American Journal of Physiology - Endocrinology and Metabolism 282, no. 5 45-5 (2002): E1014-E1022.
  - Tanner, CJ, Koves, TR, Cortright, RL, Pories, WJ, Kim, Y-B, Kahn, BB, Dohm, GL, and Houmard, JA. "Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men." American Journal of Physiology. Endocrinology and Metabolism 282, no. 1 (January 2002): E147-E153. Full Text
  - Tanner, CJ, Koves, TR, Cortright, RL, Pories, WJ, Kim, Y-B, Kahn, BB, Dohm, GL, and Houmard, JA. "Adrenomedullin expression in rat uterus is correlated with plasma estradiol." American Journal of Physiology - Endocrinology and Metabolism 282, no. 1 45-1 (2002): E139-E146.
  - Hickner, RC, Mehta, PM, Dyck, D, Devita, P, Houmard, JA, Koves, T, and Byrd, P. "Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running." Journal of Applied Physiology (Bethesda, Md. : 1985) 90, no. 4 (April 2001): 1334-1341. Full Text
  - Koves, TR, and Cortright, RN. "Comparison of palmitate oxidative capacities of isolated mitochondrial subpopulations from rat skeletal muscle by CO2 and acid soluble metabolite production." FASEB JOURNAL 15, no. 5 (March 8, 2001): A815-A815. Link to Item
  - Noland, RC, Fannon, WR, Koves, TR, Conright, RN, and Lust, RM. "Myocardial palmitate oxidation in spontaneously hypertensive corpulent rats." FASEB JOURNAL 15, no. 5 (March 8, 2001): A1142-A1142. Link to Item
  - Fannon, WR, Noland, RC, Koves, TR, Bennett, JM, Hickner, RC, and Cortright, RN. "Reduced insulin action and elevated fatty acid oxidation in obese-hypertensive rats." FASEB JOURNAL 15, no. 4 (March 7, 2001): A77-A77. Link to Item
  - Berry, MJ, Koves, TR, and Benedetto, JJ. "The influence of speed, grade and mass during simulated off road bicycling." Applied Ergonomics 31, no. 5 (October 2000): 531-536. Full Text
  - Cortright, RN, and Koves, TR. "Sex differences in substrate metabolism and energy homeostasis." Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee 25, no. 4 (August 2000): 288-311. (Review) Full Text
  - Houmard, JA, Weidner, ML, Koves, TR, Hickner, RC, and Cortright, RL. "Association between muscle fiber composition and blood pressure levels during exercise in men." Am J Hypertens 13, no. 6 Pt 1 (June 2000): 586-592. Link to Item
  - Houmard, JA, Weidner, ML, Koves, TR, Hickner, RC, and Cortright, RL. "Association between muscle fiber composition and blood pressure levels during exercise in men." American Journal of Hypertension 13, no. 6 I (2000): 586-592. Full Text
  - Hemby, SE, Co, C, Koves, TR, Smith, JE, and Dworkin, SI. "Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat." Psychopharmacology 133, no. 1 (September 1997): 7-16. Full Text
  - Dworkin, SI, Gleeson, S, Meloni, D, Koves, TR, and Martin, TJ. "Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats." Psychopharmacology (Berl) 117, no. 3 (February 1995): 257-261. Link to Item
  - Vrana, SL, Vrana, KE, Koves, TR, Smith, JE, and Dworkin, SI. "Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels." Journal of Neurochemistry 61, no. 6 (December 1993): 2262-2268. Full Text

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