Overview
Current Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Geriatrics and Palliative Care,
Medicine
Member of Sarah W. Stedman Nutrition & Metabolism Center
·
2002 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Senior Fellow of the Center for the Study of Aging and Human Development
·
2020 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Recent Publications
Formation of I2+III2 supercomplex rescues respiratory chain defects.
Journal Article Cell Metab · February 4, 2025 Mitochondrial electron transport chain (ETC) complexes partition between free complexes and quaternary assemblies known as supercomplexes (SCs). However, the physiological requirement for SCs and the mechanisms regulating their formation remain controversi ... Full text Link to item CiteBioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy.
Journal Article Adv Sci (Weinh) · August 2024 Dysferlin is a multi-functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysferlinopathies - rar ... Full text Link to item CiteKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding.
Journal Article Cell Metab · February 6, 2024 Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study questioned if the health benefits of an intermittent TRF (iTRF) schedule require ketone flux specifically in skeletal and cardiac muscles. No ... Full text Link to item CiteRecent Grants
Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2010 - 2028Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
ResearchInvestigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027Ketone Body Metabolism and Integrated Metabolic Homeostasis
ResearchInvestigator · Awarded by University of Minnesota · 2020 - 2026View All Grants
Education, Training & Certifications
East Carolina University ·
2006
M.B.A.
East Carolina University ·
2002
Ph.D.