Overview
Current Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Geriatrics and Palliative Care,
Medicine
Member of Sarah W. Stedman Nutrition & Metabolism Center
·
2002 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Senior Fellow of the Center for the Study of Aging and Human Development
·
2020 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Recent Publications
Abstract Wed007: Postnatal loss of the nuclear receptor PPARĪ± in cardiomyocytes promotes glycolytic remodeling and cardiomyocyte dedifferentiation via Fbp2 downregulation
Conference Circulation Research · August 2025 Cardiomyocytes (CMs) undergo metabolic and contractile reprogramming during cardiac stress and injury. This reprogramming response includes a fuel metabolic shift to a more fetal-like or immature state with downregulation in fatty acid ... Full text CiteFormation of I2+III2 supercomplex rescues respiratory chain defects.
Journal Article Cell Metab · February 4, 2025 Mitochondrial electron transport chain (ETC) complexes partition between free complexes and quaternary assemblies known as supercomplexes (SCs). However, the physiological requirement for SCs and the mechanisms regulating their formation remain controversi ... Full text Link to item CiteBioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy.
Journal Article Adv Sci (Weinh) · August 2024 Dysferlin is a multi-functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysferlinopathies - rar ... Full text Link to item CiteRecent Grants
Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2010 - 2028Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
ResearchInvestigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027Microbial regulation of intestinal lipid metabolism and its physiological consequences
ResearchAssociate Research Professor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2021 - 2026View All Grants
Education
East Carolina University ·
2006
M.B.A.
East Carolina University ·
2002
Ph.D.