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The mitochondrial multi-omic response to exercise training across rat tissues.

Publication ,  Journal Article
Amar, D; Gay, NR; Jimenez-Morales, D; Jean Beltran, PM; Ramaker, ME; Raja, AN; Zhao, B; Sun, Y; Marwaha, S; Gaul, DA; Hershman, SG; Xia, A ...
Published in: Cell Metab
June 4, 2024

Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta-hydroxysteroid dehydrogenase 10 (HSD17B10) elevated oxygen consumption, indicative of metabolic stress. We provide a multi-omic, multi-tissue, temporal atlas of the mitochondrial response to exercise training and identify candidates linked to mitochondrial dysfunction.

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 4, 2024

Volume

36

Issue

6

Start / End Page

1411 / 1429.e10

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Physical Conditioning, Animal
  • Muscle, Skeletal
  • Multiomics
  • Mitochondria
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

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Amar, D., Gay, N. R., Jimenez-Morales, D., Jean Beltran, P. M., Ramaker, M. E., Raja, A. N., … MoTrPAC Study Group. (2024). The mitochondrial multi-omic response to exercise training across rat tissues. Cell Metab, 36(6), 1411-1429.e10. https://doi.org/10.1016/j.cmet.2023.12.021
Amar, David, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, et al. “The mitochondrial multi-omic response to exercise training across rat tissues.Cell Metab 36, no. 6 (June 4, 2024): 1411-1429.e10. https://doi.org/10.1016/j.cmet.2023.12.021.
Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, et al. The mitochondrial multi-omic response to exercise training across rat tissues. Cell Metab. 2024 Jun 4;36(6):1411-1429.e10.
Amar, David, et al. “The mitochondrial multi-omic response to exercise training across rat tissues.Cell Metab, vol. 36, no. 6, June 2024, pp. 1411-1429.e10. Pubmed, doi:10.1016/j.cmet.2023.12.021.
Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul DA, Hershman SG, Ferrasse A, Xia A, Lanza I, Fernández FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group. The mitochondrial multi-omic response to exercise training across rat tissues. Cell Metab. 2024 Jun 4;36(6):1411-1429.e10.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 4, 2024

Volume

36

Issue

6

Start / End Page

1411 / 1429.e10

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Physical Conditioning, Animal
  • Muscle, Skeletal
  • Multiomics
  • Mitochondria
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism