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Olga Ilkayeva

Assistant Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Box 104775, Durham, NC 27710
300 N Duke St, 48-205, Durham, NC 27701

Overview


Olga Ilkayeva, Ph.D., is the Director of the Metabolomics Core Laboratory at Duke Molecular Physiology Institute. She received her Ph.D. training in Cell Regulation from UT Southwestern Medical Center at Dallas, TX. Her postdoctoral research in the laboratory of Dr. Chris Newgard at Duke University Medical Center focused on lipid metabolism and regulation of insulin secretion. As a research scientist at the Stedman Nutrition and Metabolism Center, Dr. Ilkayeva expanded her studies to include the development of targeted mass spectrometry analyses. Currently, she works on developing and validating quantitative mass spectrometry methods used for metabolic profiling of various biological models with emphasis on diabetes, obesity, cardiovascular disease, and the role of gut microbiome in both health and disease.

Current Appointments & Affiliations


Assistant Professor in Medicine · 2020 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Duke Molecular Physiology Institute · 2020 - Present Duke Molecular Physiology Institute, Institutes and Centers

Recent Publications


Acute perioperative alterations in metabolism: A pilot study using mass spectrometry-based metabolomics.

Journal Article Surgery · April 2025 OBJECTIVE: To characterize early physiologic stresses imposed by surgery by applying metabolomic analyses to deeply phenotype pre- and postoperative plasma and urine of patients undergoing elective surgical procedures. BACKGROUND: Patients experience perio ... Full text Link to item Cite

Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia.

Journal Article bioRxiv · March 2, 2025 Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights 1,2 , but they miss ... Full text Link to item Cite

Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF.

Journal Article JACC Basic Transl Sci · March 2025 Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ... Full text Link to item Cite
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Recent Grants


The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026

NCDRC P&F April 2022

ResearchCollaborator · Awarded by Wake Forest University · 2021 - 2023

KLF15 in Skeletal Muscle Lipid Metabolism

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2017 - 2022

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Education, Training & Certifications


University of Texas Southwestern Medical Center, Medical School · 2002 Ph.D.