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Olga Ilkayeva

Assistant Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Box 104775, Durham, NC 27710
300 N Duke St, 48-205, Durham, NC 27701

Overview


Olga Ilkayeva, Ph.D., is the Director of the Metabolomics Core Laboratory at Duke Molecular Physiology Institute. She received her Ph.D. training in Cell Regulation from UT Southwestern Medical Center at Dallas, TX. Her postdoctoral research in the laboratory of Dr. Chris Newgard at Duke University Medical Center focused on lipid metabolism and regulation of insulin secretion. As a research scientist at the Stedman Nutrition and Metabolism Center, Dr. Ilkayeva expanded her studies to include the development of targeted mass spectrometry analyses. Currently, she works on developing and validating quantitative mass spectrometry methods used for metabolic profiling of various biological models with emphasis on diabetes, obesity, cardiovascular disease, and the role of gut microbiome in both health and disease.

Current Appointments & Affiliations


Assistant Professor in Medicine · 2020 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Duke Molecular Physiology Institute · 2020 - Present Duke Molecular Physiology Institute, Institutes and Centers

Recent Publications


Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.

Journal Article Nat Metab · December 2025 Understanding how cellular pathways interact is crucial for treating complex diseases like cancer. Individual gene-gene interaction studies have provided valuable insights, but may miss pathways working together. Here we develop a multi-gene approach to pa ... Full text Link to item Cite

Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.

Journal Article J Clin Endocrinol Metab · October 16, 2025 CONTEXT: While increased fiber intake may benefit appetite and metabolism in the general population, its effects in individuals with Prader-Willi syndrome (PWS), a condition characterized by hyperphagia, obesity, and metabolic dysregulation, remain to be e ... Full text Link to item Cite

The impact of lifestyle modification on metabolic pathways in older adults with overweight/obesity and rheumatoid arthritis: a secondary exploratory analysis of the SWET-RA study.

Journal Article BMC Rheumatol · June 9, 2025 BACKGROUND: Rheumatoid arthritis (RA) is associated with increased cardiometabolic risk due to inflammation and traditional risk factors, both of which can be mitigated by lifestyle modifications. This study examines metabolic pathways influenced by lifest ... Full text Open Access Link to item Cite
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Recent Grants


The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026

NCDRC P&F April 2022

ResearchCollaborator · Awarded by Wake Forest University · 2021 - 2023

KLF15 in Skeletal Muscle Lipid Metabolism

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2017 - 2022

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Education, Training & Certifications


University of Texas Southwestern Medical Center, Medical School · 2002 Ph.D.