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Olga Ilkayeva

Assistant Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Box 104775, Durham, NC 27710
300 N Duke St, 48-205, Durham, NC 27701

Research Interests


The DMPI Metabolomics Core is a leader in applying both targeted and non-targeted mass spectrometry (MS)-based metabolomics to better detect and understand chronic human diseases. The laboratory is equipped with a comprehensive suite of twelve MS instruments (Waters, Agilent, Sciex, and Thermo Fisher) that allow both targeted and non-targeted metabolomics assays to be conducted on a wide array of sample types including plasma, blood spots, tissue, urine, cerebral spinal fluid, and cell culture. For targeted analyses, the lab deploys four triple quadrupole (MS/MS) instruments and a gas chromatography (GC)/MS instrument to measure more than 300 specific metabolites across seven chemical classes: 1) 66 species of acylcarnitines; 2) 47 amino acids and biogenic amines 3) 67 acyl CoAs species; 4) 20 organic acids; 5) 21 ceramides; 6) 34 sphingomyelins, and 7) 36 nucleotides and purine/pyrimidine pathway intermediates. Accurate quantitation of the metabolites in the targeted assays is achieved by using isotope dilution or pseudo-isotope dilution techniques and quality control calibrators derived from biologic matrices and commercially available analytical standards.

Selected Grants


The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026

NCDRC P&F April 2022

ResearchCollaborator · Awarded by Wake Forest University · 2021 - 2023

KLF15 in Skeletal Muscle Lipid Metabolism

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2017 - 2022

Collaborative Activities to Promote Metabolomics Research (Admin.Supp)

ResearchPrincipal Investigator · Awarded by Joslin Diabetes Center, Inc · 2015 - 2016

Sponsored Research Agreement with Wake Forest University

ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2014 - 2014

Exceptional Survival: Trajectoriees to Functional Aging (CHS All Stairs)

ResearchPrincipal Investigator · Awarded by University of Pittsburgh · 2013 - 2014

Integration of Oncogenic Networks in Cancer Phenotypes

ResearchResearch Scientist · Awarded by National Institutes of Health · 2004 - 2011