Cardiovascular Outcome Trial Update in Diabetes: New Evidence, Remaining Questions.
Journal Article (Journal Article;Review)
PURPOSE OF REVIEW: Seven trials of new agents to treat type 2 diabetes (T2DM) have been performed to assess cardiovascular (CV) safety. A significant amount of information regarding the effects of drugs in three classes is available, with new data from multiple other trials expected shortly. This article provides a summary of recently completed trials. RECENT FINDINGS: The dipeptidyl peptidase-4 inhibitors studied thus far do not alter the risk of major adverse CV events (MACE). Glucagon like peptide-1 receptor agonists liraglutide and semaglutide, and the sodium glucose cotransporter-2 inhibitor empagliflozin, significantly reduced the risk of MACE. Empagliflozin also decreased the risk of hospitalization for heart failure. Agents demonstrating a CV outcome benefit also improved parameters of renal function. Several newer antihyperglycemic agents have been found to reduce the risk of important CV complications in high-risk patients with T2DM. Future trials are needed to assess the effects of additional drugs and the impact of therapy in lower risk patients and provide additional information regarding non-CV safety outcomes.
Full Text
Duke Authors
Cited Authors
- Herbst, R; Bolton, W; Shariff, A; Green, JB
Published Date
- September 2017
Published In
Volume / Issue
- 17 / 9
Start / End Page
- 67 -
PubMed ID
- 28726152
Electronic International Standard Serial Number (EISSN)
- 1539-0829
Digital Object Identifier (DOI)
- 10.1007/s11892-017-0898-8
Language
- eng
Conference Location
- United States