Afreen Idris Shariff | Scholars@Duke

Afreen Idris Shariff
Assistant Professor of Medicine

Afreen Shariff, MD is an endocrinologist with expertise in endocrine disease in cancer patients. She is the Director of the Duke Endo-Oncology Program and an Associate Director for the Cancer Therapy Toxicity Program at the Duke Center for Cancer Immunotherapy. She holds a faculty appointment as an Assistant Professor of Medicine in the Division of Endocrinology, Diabetes and Metabolism at Duke University School of Medicine.

Dr. Shariff completed her medical school in India from Deccan College of Medical Sciences, Internal Medicine training from East Carolina University’s Brody School of Medicine and fellowship in Endocrinology from Duke University School of Medicine. Her clinical work and research is focused on high value care for endocrine disease in cancer patients.

She also chairs the Oncoendocrinology Special Interest Group (SIG) with the Endocrine Society and influences global networking, clinical practice and education in the field of Oncoendocrinology. At Duke, Dr. Shariff's work includes developing interdisciplinary partnerships, creating the clinical infrastructure and framework needed for AI assisted clinical decision making to improve access and coordinated care for patients with cancer therapy related toxicities. She also hosts and produces the podcast series Checkpoint NOW that emphasizes shared decision making between oncologists and subspecialists

Current Research Interests

Profiling immune related adverse events, predicting IRAEs

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

Duke Health- Endocrinology

Background
Education, Training, & Certifications
- Fellowship in Endocrinology, Metabolism and Nutrition, Medicine, Duke University School of Medicine 2015 - 2017
- Internal Medicine Residency, East Carolina University, Brody School of Medicine 2011 - 2014
- M.B.B.S., University of Hyderabad (India) 2008
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2017 - 2020
Recognition
In the News
- JAN 15, 2021
  
  Checkpoint NOW podcast launch
- NOV 13, 2020 The Doctors show
  
  What to Know If You’re Going to Buy Black Market Insulin
- JUN 4, 2019
  
  Checkpoint Immune Agents Trigger High-Risk Reaction in Patient with Cancer
- FEB 12, 2019
  
  Endocrinologist Tackles Side Effects of Immunotherapy Cancer Treatments
Awards & Honors
- Banting and Best award . East Carolina University. 2014
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ferreira, Michelle N., Meghana Rao, Arif H. Kamal, and Afreen Shariff. “Top Ten Tips Palliative Care Clinicians Should Know About Managing Immune-Mediated Endocrine Toxicities in Cancer.” J Palliat Med 25, no. 11 (November 2022): 1715–20. https://doi.org/10.1089/jpm.2022.0204.
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  - Ferreira, M. N., and A. I. Shariff. “Iatrogenic Cushing's syndrome presenting with adrenal insufficiency in 2 patients receiving dexamethasone for metastatic colorectal cancer through an intrahepatic arterial infusion pump.” Current Problems in Cancer: Case Reports 7 (September 1, 2022). https://doi.org/10.1016/j.cpccr.2022.100177.
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  - Clarke, Jeffrey M., Lin Gu, Xiaofei F. Wang, Thomas E. Stinchcombe, Marvaretta M. Stevenson, Sundhar Ramalingam, Afreen Shariff, et al. “A Phase 2 Clinical Trial of Combination Nivolumab, Ipilimumab, and Paclitaxel in Patients With Untreated Metastatic NSCLC: The OPTIMAL Trial.” Jto Clin Res Rep 3, no. 6 (June 2022): 100337. https://doi.org/10.1016/j.jtocrr.2022.100337.
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  - Lee, T., M. Hu, Q. Gao, J. Amason, D. Borkar, D. D’Alessio, M. Canos, A. Shariff, M. Pajic, and M. Hadziahmetovic. “Evaluation of a deep learning supported remote diagnosis model for identification of diabetic retinopathy using wide-field Optomap.” Annals of Eye Science 7 (June 1, 2022). https://doi.org/10.21037/aes-21-53.
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  - Atiq, Saad, Nathan Hirshman, Afreen Shariff, and Tian Zhang. “The management of toxicities from immune, targeted and ADCs treatments in patients with urothelial cancer.” Urol Oncol, December 30, 2021. https://doi.org/10.1016/j.urolonc.2021.10.002.
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  - Anders, Carey K., Nicole R. LeBoeuf, Lara Bashoura, Saadia A. Faiz, Afreen I. Shariff, and Alexandra Thomas. “What's the Price? Toxicities of Targeted Therapies in Breast Cancer Care.” Am Soc Clin Oncol Educ Book 40 (May 2020): 55–70. https://doi.org/10.1200/EDBK_279465.
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  - Merrill, Jennifer D., Diana Soliman, Nitya Kumar, Sooyoung Lim, Afreen I. Shariff, and William S. Yancy. “Low-Carbohydrate and Very-Low-Carbohydrate Diets in Patients With Diabetes.” Diabetes Spectr 33, no. 2 (May 2020): 133–42. https://doi.org/10.2337/ds19-0070.
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  - Shariff, Afreen I., Nitya Kumar, William S. Yancy, and Leonor Corsino. “Type 2 Diabetes and Atherosclerotic Cardiovascular Disease in South Asians: a Unique Population with a Growing Challenge.” Curr Diab Rep 20, no. 1 (January 30, 2020): 4. https://doi.org/10.1007/s11892-020-1291-6.
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  - Shariff, Afreen Idris, Sohail Syed, Rebecca A. Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio, and Leonor Corsino. “Novel cancer therapies and their association with diabetes.” J Mol Endocrinol 62, no. 2 (February 1, 2019): R187–99. https://doi.org/10.1530/JME-18-0002.
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  - Stahl, Jennifer, Niki Winters, and Afreen Shariff. “A RARE CASE OF PRIMARY HYPERPARATHYROIDISM, HYPEREMESIS GRAVIDARUM, AND WERNICKE ENCEPHALOPATHY.” Aace Clin Case Rep 5, no. 2 (2019): e108–11. https://doi.org/10.4158/ACCR-2018-0286.
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  - Shariff, A. I., and D. A. D’Alessio. “Primary Adrenal Insufficiency from Immune Checkpoint Inhibitors.” Aace Clinical Case Reports 4, no. 3 (May 1, 2018): 232–34. https://doi.org/10.4158/ACCR-2017-0133.
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  - Herbst, Rebecca, Wilburn Bolton, Afreen Shariff, and Jennifer B. Green. “Cardiovascular Outcome Trial Update in Diabetes: New Evidence, Remaining Questions.” Curr Diab Rep 17, no. 9 (September 2017): 67. https://doi.org/10.1007/s11892-017-0898-8.
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  - Misaghian-Xanthos, Negin, Afreen I. Shariff, Kavya Mekala, Loretta R. Fearrington, Tracy L. Setji, Joseph A. Aloi, and John B. Buse. “Sodium-Glucose Cotransporter 2 Inhibitors and Diabetic Ketoacidosis: A Case Series From Three Academic Institutions.” Diabetes Care 40, no. 6 (June 2017): e65–66. https://doi.org/10.2337/dc16-2591.
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  - Shariff, Afreen I., Xiangming Fang, and Tejas Desai. “Using social media to create a professional network between physician-trainees and the American Society of Nephrology.” Adv Chronic Kidney Dis 20, no. 4 (July 2013): 357–63. https://doi.org/10.1053/j.ackd.2013.03.005.
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  - Desai, Tejas, Afreen Shariff, Vibhu Dhingra, Deeba Minhas, Megan Eure, and Mark Kats. “Is content really king? An objective analysis of the public's response to medical videos on YouTube.” Plos One 8, no. 12 (2013): e82469. https://doi.org/10.1371/journal.pone.0082469.
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  - Desai, Tejas, Afreen Shariff, Aabid Shariff, Mark Kats, Xiangming Fang, Cynthia Christiano, and Maria Ferris. “Tweeting the meeting: an in-depth analysis of Twitter activity at Kidney Week 2011.” Plos One 7, no. 7 (2012): e40253. https://doi.org/10.1371/journal.pone.0040253.
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  - Rajkumar, R., A. I. Shariff, J. -. I. Choi, G. T. Huang, K. V. Pandit, J. C. Sembrat, D. C. Ishizawar, et al. “Integration of Genome-Wide MicroRNA and mRNA Expression Profiles in Pulmonary Arterial Hypertension and Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis.” Circulation 124:A15511, no. 21 (November 22, 2011).
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- Book Sections
  - Shariff, A. I., L. Gratian, and J. Perkins. “A Rare Presentation of TSH Secreting Pituitary Macroadenoma with Coexisting Primary Hypothyroidism from Hashimoto’s Thyroiditis.” In The Art of Neuroendocrinology: A Case-Based Approach to Medical Decision-Making, edited by L. Blevins, Jr. Nova Science Pub Inc, 2017.
- Conference Papers
  - Desai, Tejas, Vibhu Dhingra, Afreen Shariff, Aabid Shariff, Edgar Lerma, Parteek Singla, Swapnil Kachare, et al. “Quantifying the Twitter Influence of Third Party Commercial Entities versus Healthcare Providers in Thirteen Medical Conferences from 2011 - 2013.” In Plos One, 11:e0162376, 2016. https://doi.org/10.1371/journal.pone.0162376.
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  - Shariff, Afreen Idris, Jennifer Laura Stahl, and Fiona J. Cook. “An Instructive Case of Hyperemesis Gravidarum, Wernicke's Encephalopathy, and Primary Hyperparathyroidism.” In Endocrine Reviews, Vol. 35. ENDOCRINE SOC, 2014.
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Teaching & Mentoring
Teaching Activities
- Duke School of Medicine
  Duke Physician Assistant School
  Duke School of Nursing
Scholarly, Clinical, & Service Activities
Service to the Profession
- Duke "Walk with a diabetes Doc". 2019 2019
Service to Duke
Clinical Activities
- Duke Endocrinology South Durham
  Duke Managing Ethnic Diabetes Efficiently Clinic
  Duke Endocrine-ImmunoOncology clinic

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Subject Headings

Global Scholarship

Expertise

Selected Publications

Academic Articles

Book Sections

Conference Papers

Teaching Activities

Service to the Profession

Service to Duke

Clinical Activities