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Afreen Idris Shariff

Associate Professor of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition

Selected Publications


Endocrinopathies Associated With Immune Checkpoint Inhibitor Use.

Journal Article Endocr Pract · June 2024 OBJECTIVE: To provide a clinical approach towards immune checkpoint inhibitor (ICI)-associated endocrinopathies, their link with cancer outcomes, factors which differentiate them from other immune related adverse events, and health systems innovation to im ... Full text Link to item Cite

Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy.

Journal Article J Immunother Cancer · April 10, 2024 With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often ... Full text Link to item Cite

Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare.

Journal Article J Am Med Inform Assoc · February 16, 2024 OBJECTIVE: The complexity and rapid pace of development of algorithmic technologies pose challenges for their regulation and oversight in healthcare settings. We sought to improve our institution's approach to evaluation and governance of algorithmic techn ... Full text Link to item Cite

Cutaneous and Noncutaneous Adverse Effects in Patients with Advanced Melanoma Receiving Immunotherapy.

Journal Article JID Innov · November 2023 Relationships between cutaneous adverse effects (CAEs) and noncutaneous adverse effects (NCAEs) of melanoma immunotherapy may help identify patterns tied to distinct immunologic pathways. The objective of this study was to determine the associations betwee ... Full text Link to item Cite

The management of toxicities from immune, targeted and ADCs treatments in patients with urothelial cancer.

Journal Article Urol Oncol · October 2023 Newly approved systemic treatment options for metastatic urothelial cancer (mUC) have diversified treatments and improved responses and survival for chemotherapy refractory disease. These systemic treatments have associated toxicities which need appropriat ... Full text Link to item Cite

Radiation of bilateral adrenal metastases is associated with a high risk of primary adrenal insufficiency.

Journal Article Clin Endocrinol (Oxf) · July 2023 BACKGROUND: Adrenal metastasis is the most common adrenal malignancy and can be bilateral in up to 43% of patients. Radiotherapy (RT) is one option available to treat adrenal metastases. The risk of primary adrenal insufficiency (PAI) after adrenal RT is u ... Full text Link to item Cite

Dearth of ICD Codes for Complications of Immune Checkpoint Inhibitors Impedes Clinical Care and Research.

Journal Article J Endocr Soc · February 9, 2023 Immune checkpoint inhibitors (ICIs) are a rapidly expanding class of targeted therapies effective in the treatment of various cancers. However, while efficacious, ICIs have been associated with treatment complications, namely immune-related adverse events ... Full text Link to item Cite

Top Ten Tips Palliative Care Clinicians Should Know About Managing Immune-Mediated Endocrine Toxicities in Cancer.

Journal Article J Palliat Med · November 2022 Immune checkpoint inhibitors (ICI), such as PD-1/PDL-1 and CTLA-4, have become widely used in the treatment of solid and hematological malignancies; their use and side effects are increasingly seen in the palliative care (PC) population. These drugs can re ... Full text Link to item Cite

A Phase 2 Clinical Trial of Combination Nivolumab, Ipilimumab, and Paclitaxel in Patients With Untreated Metastatic NSCLC: The OPTIMAL Trial.

Journal Article JTO Clin Res Rep · June 2022 INTRODUCTION: Most patients with advanced NSCLC will experience disease progression and death within 2 years. Novel approaches are needed to improve outcomes. METHODS: We conducted an open-label, nonrandomized, phase 2 trial in patients with treatment-naiv ... Full text Link to item Cite

Evaluation of a deep learning supported remote diagnosis model for identification of diabetic retinopathy using wide-field Optomap

Journal Article Annals of Eye Science · June 1, 2022 Background: We test a deep learning (DL) supported remote diagnosis approach to detect diabetic retinopathy (DR) and other referable retinal pathologies using ultra-wide-field (UWF) Optomap. Methods: Prospective, non-randomized study involving diabetic pat ... Full text Cite

Development and Validation of ML-DQA - a Machine Learning Data Quality Assurance Framework for Healthcare

Conference Proceedings of Machine Learning Research · January 1, 2022 The approaches by which the machine learning and clinical research communities utilize real world data (RWD), including data captured in the electronic health record (EHR), vary dramatically. While clinical researchers cautiously use RWD for clinical inves ... Cite

What's the Price? Toxicities of Targeted Therapies in Breast Cancer Care.

Journal Article Am Soc Clin Oncol Educ Book · May 2020 Agents with mechanisms novel to breast cancer care have been approved to treat breast cancer. These agents include drugs that target cyclin-dependent kinases, phosphoinositide 3-kinase PI3KCA gene mutations, PARP, checkpoint regulation, and novel antibody- ... Full text Link to item Cite

Low-Carbohydrate and Very-Low-Carbohydrate Diets in Patients With Diabetes.

Journal Article Diabetes Spectr · May 2020 Low-carbohydrate diets have been advocated as an effective method for promoting weight loss in overweight and obese individuals and preventing and treating type 2 diabetes. This article reviews the differences between various low-carbohydrate eating plans ... Full text Link to item Cite

Type 2 Diabetes and Atherosclerotic Cardiovascular Disease in South Asians: a Unique Population with a Growing Challenge.

Journal Article Curr Diab Rep · January 30, 2020 PURPOSE OF REVIEW: The purpose of this review is to summarize our current knowledge of factors that influence clinical decision making and management of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) among South Asians ( ... Full text Link to item Cite

Novel cancer therapies and their association with diabetes.

Journal Article J Mol Endocrinol · February 1, 2019 Over the last decade, there has been a shift in the focus of cancer therapy from conventional cytotoxic drugs to therapies more specifically directed to cancer cells. These novel therapies include immunotherapy, targeted therapy and precision medicine, eac ... Full text Link to item Cite

A RARE CASE OF PRIMARY HYPERPARATHYROIDISM, HYPEREMESIS GRAVIDARUM, AND WERNICKE ENCEPHALOPATHY.

Journal Article AACE Clin Case Rep · 2019 OBJECTIVE: To describe a rare case of Wernicke encephalopathy (WE) as a result of hyperemesis gravidarum due to primary hyperparathyroidism (PHPT) in pregnancy. METHODS: We present the clinical presentation, supportive laboratory values, diagnostic dilemma ... Full text Link to item Cite

Primary Adrenal Insufficiency from Immune Checkpoint Inhibitors

Journal Article AACE Clinical Case Reports · May 1, 2018 Objective: To describe a rare case of primary adrenal insufficiency (PAI) from immune checkpoint inhibitors (ICPIs). Methods: We describe the clinical presentation, supportive laboratory findings, long-term outcomes, and a review of the current available l ... Full text Cite

Cardiovascular Outcome Trial Update in Diabetes: New Evidence, Remaining Questions.

Journal Article Curr Diab Rep · September 2017 PURPOSE OF REVIEW: Seven trials of new agents to treat type 2 diabetes (T2DM) have been performed to assess cardiovascular (CV) safety. A significant amount of information regarding the effects of drugs in three classes is available, with new data from mul ... Full text Link to item Cite

Endocrinopathies Associated With Immune Checkpoint Inhibitor Use.

Journal Article Endocr Pract · June 2024 OBJECTIVE: To provide a clinical approach towards immune checkpoint inhibitor (ICI)-associated endocrinopathies, their link with cancer outcomes, factors which differentiate them from other immune related adverse events, and health systems innovation to im ... Full text Link to item Cite

Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy.

Journal Article J Immunother Cancer · April 10, 2024 With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often ... Full text Link to item Cite

Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare.

Journal Article J Am Med Inform Assoc · February 16, 2024 OBJECTIVE: The complexity and rapid pace of development of algorithmic technologies pose challenges for their regulation and oversight in healthcare settings. We sought to improve our institution's approach to evaluation and governance of algorithmic techn ... Full text Link to item Cite

Cutaneous and Noncutaneous Adverse Effects in Patients with Advanced Melanoma Receiving Immunotherapy.

Journal Article JID Innov · November 2023 Relationships between cutaneous adverse effects (CAEs) and noncutaneous adverse effects (NCAEs) of melanoma immunotherapy may help identify patterns tied to distinct immunologic pathways. The objective of this study was to determine the associations betwee ... Full text Link to item Cite

The management of toxicities from immune, targeted and ADCs treatments in patients with urothelial cancer.

Journal Article Urol Oncol · October 2023 Newly approved systemic treatment options for metastatic urothelial cancer (mUC) have diversified treatments and improved responses and survival for chemotherapy refractory disease. These systemic treatments have associated toxicities which need appropriat ... Full text Link to item Cite

Radiation of bilateral adrenal metastases is associated with a high risk of primary adrenal insufficiency.

Journal Article Clin Endocrinol (Oxf) · July 2023 BACKGROUND: Adrenal metastasis is the most common adrenal malignancy and can be bilateral in up to 43% of patients. Radiotherapy (RT) is one option available to treat adrenal metastases. The risk of primary adrenal insufficiency (PAI) after adrenal RT is u ... Full text Link to item Cite

Dearth of ICD Codes for Complications of Immune Checkpoint Inhibitors Impedes Clinical Care and Research.

Journal Article J Endocr Soc · February 9, 2023 Immune checkpoint inhibitors (ICIs) are a rapidly expanding class of targeted therapies effective in the treatment of various cancers. However, while efficacious, ICIs have been associated with treatment complications, namely immune-related adverse events ... Full text Link to item Cite

Top Ten Tips Palliative Care Clinicians Should Know About Managing Immune-Mediated Endocrine Toxicities in Cancer.

Journal Article J Palliat Med · November 2022 Immune checkpoint inhibitors (ICI), such as PD-1/PDL-1 and CTLA-4, have become widely used in the treatment of solid and hematological malignancies; their use and side effects are increasingly seen in the palliative care (PC) population. These drugs can re ... Full text Link to item Cite

A Phase 2 Clinical Trial of Combination Nivolumab, Ipilimumab, and Paclitaxel in Patients With Untreated Metastatic NSCLC: The OPTIMAL Trial.

Journal Article JTO Clin Res Rep · June 2022 INTRODUCTION: Most patients with advanced NSCLC will experience disease progression and death within 2 years. Novel approaches are needed to improve outcomes. METHODS: We conducted an open-label, nonrandomized, phase 2 trial in patients with treatment-naiv ... Full text Link to item Cite

Evaluation of a deep learning supported remote diagnosis model for identification of diabetic retinopathy using wide-field Optomap

Journal Article Annals of Eye Science · June 1, 2022 Background: We test a deep learning (DL) supported remote diagnosis approach to detect diabetic retinopathy (DR) and other referable retinal pathologies using ultra-wide-field (UWF) Optomap. Methods: Prospective, non-randomized study involving diabetic pat ... Full text Cite

Development and Validation of ML-DQA - a Machine Learning Data Quality Assurance Framework for Healthcare

Conference Proceedings of Machine Learning Research · January 1, 2022 The approaches by which the machine learning and clinical research communities utilize real world data (RWD), including data captured in the electronic health record (EHR), vary dramatically. While clinical researchers cautiously use RWD for clinical inves ... Cite

What's the Price? Toxicities of Targeted Therapies in Breast Cancer Care.

Journal Article Am Soc Clin Oncol Educ Book · May 2020 Agents with mechanisms novel to breast cancer care have been approved to treat breast cancer. These agents include drugs that target cyclin-dependent kinases, phosphoinositide 3-kinase PI3KCA gene mutations, PARP, checkpoint regulation, and novel antibody- ... Full text Link to item Cite

Low-Carbohydrate and Very-Low-Carbohydrate Diets in Patients With Diabetes.

Journal Article Diabetes Spectr · May 2020 Low-carbohydrate diets have been advocated as an effective method for promoting weight loss in overweight and obese individuals and preventing and treating type 2 diabetes. This article reviews the differences between various low-carbohydrate eating plans ... Full text Link to item Cite

Type 2 Diabetes and Atherosclerotic Cardiovascular Disease in South Asians: a Unique Population with a Growing Challenge.

Journal Article Curr Diab Rep · January 30, 2020 PURPOSE OF REVIEW: The purpose of this review is to summarize our current knowledge of factors that influence clinical decision making and management of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) among South Asians ( ... Full text Link to item Cite

Novel cancer therapies and their association with diabetes.

Journal Article J Mol Endocrinol · February 1, 2019 Over the last decade, there has been a shift in the focus of cancer therapy from conventional cytotoxic drugs to therapies more specifically directed to cancer cells. These novel therapies include immunotherapy, targeted therapy and precision medicine, eac ... Full text Link to item Cite

A RARE CASE OF PRIMARY HYPERPARATHYROIDISM, HYPEREMESIS GRAVIDARUM, AND WERNICKE ENCEPHALOPATHY.

Journal Article AACE Clin Case Rep · 2019 OBJECTIVE: To describe a rare case of Wernicke encephalopathy (WE) as a result of hyperemesis gravidarum due to primary hyperparathyroidism (PHPT) in pregnancy. METHODS: We present the clinical presentation, supportive laboratory values, diagnostic dilemma ... Full text Link to item Cite

Primary Adrenal Insufficiency from Immune Checkpoint Inhibitors

Journal Article AACE Clinical Case Reports · May 1, 2018 Objective: To describe a rare case of primary adrenal insufficiency (PAI) from immune checkpoint inhibitors (ICPIs). Methods: We describe the clinical presentation, supportive laboratory findings, long-term outcomes, and a review of the current available l ... Full text Cite

Cardiovascular Outcome Trial Update in Diabetes: New Evidence, Remaining Questions.

Journal Article Curr Diab Rep · September 2017 PURPOSE OF REVIEW: Seven trials of new agents to treat type 2 diabetes (T2DM) have been performed to assess cardiovascular (CV) safety. A significant amount of information regarding the effects of drugs in three classes is available, with new data from mul ... Full text Link to item Cite

Quantifying the Twitter Influence of Third Party Commercial Entities versus Healthcare Providers in Thirteen Medical Conferences from 2011 - 2013.

Conference PLoS One · 2016 INTRODUCTION: Twitter channels are increasingly popular at medical conferences. Many groups, including healthcare providers and third party entities (e.g., pharmaceutical or medical device companies) use these channels to communicate with one another. Thes ... Full text Link to item Cite

Using social media to create a professional network between physician-trainees and the American Society of Nephrology.

Journal Article Adv Chronic Kidney Dis · July 2013 Twitter is the fastest growing social media network. It offers participants the ability to network with other individuals. Medical societies are interested in helping individuals network to boost recruitment, encourage collaboration, and assist in job plac ... Full text Link to item Cite

Is content really king? An objective analysis of the public's response to medical videos on YouTube.

Journal Article PLoS One · 2013 Medical educators and patients are turning to YouTube to teach and learn about medical conditions. These videos are from authors whose credibility cannot be verified & are not peer reviewed. As a result, studies that have analyzed the educational content o ... Full text Link to item Cite

Tweeting the meeting: an in-depth analysis of Twitter activity at Kidney Week 2011.

Journal Article PLoS One · 2012 In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method used by the Society to accomplish t ... Full text Link to item Cite

Integration of Genome-Wide MicroRNA and mRNA Expression Profiles in Pulmonary Arterial Hypertension and Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis

Journal Article Circulation · November 22, 2011 Objective: To determine the role of microRNAs in the pathogenesis of pulmonary arterial hypertension (PAH). Background: PAH is a life-threatening condition characterized by pulmonary arteriolar remodeling, progressive elevation of pulmonary artery pressur ... Link to item Cite