
Top Ten Tips Palliative Care Clinicians Should Know About Managing Immune-Mediated Endocrine Toxicities in Cancer.
Immune checkpoint inhibitors (ICI), such as PD-1/PDL-1 and CTLA-4, have become widely used in the treatment of solid and hematological malignancies; their use and side effects are increasingly seen in the palliative care (PC) population. These drugs can result in immune-mediated endocrinopathies; the thyroid is the most common endocrine gland affected, but the pituitary, adrenals, and pancreas may be affected as well. Symptoms may be insidious and nonspecific. A high index of suspicion and routine laboratory monitoring allows for prompt diagnosis and treatment, which can significantly improve symptoms and increase quality of life. In this study, we present an approach to monitoring and initial management of ICI-induced endocrinopathies in the PC patient population.
Duke Scholars
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Related Subject Headings
- Quality of Life
- Palliative Care
- Neoplasms
- Immunotherapy
- Humans
- Gerontology
- Endocrine System Diseases
- 1117 Public Health and Health Services
- 1110 Nursing
- 1103 Clinical Sciences
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Quality of Life
- Palliative Care
- Neoplasms
- Immunotherapy
- Humans
- Gerontology
- Endocrine System Diseases
- 1117 Public Health and Health Services
- 1110 Nursing
- 1103 Clinical Sciences