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Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.

Publication ,  Journal Article
Schell, WA; Jones, AM; Borroto-Esoda, K; Alexander, BD
Published in: Antimicrob Agents Chemother
November 2017

SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.

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Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

November 2017

Volume

61

Issue

11

Location

United States

Related Subject Headings

  • Voriconazole
  • Triterpenes
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Glycosides
  • Echinocandins
  • Drug Resistance, Fungal
  • Candida
  • Antifungal Agents
 

Citation

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Schell, W. A., Jones, A. M., Borroto-Esoda, K., & Alexander, B. D. (2017). Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species. Antimicrob Agents Chemother, 61(11). https://doi.org/10.1128/AAC.01102-17
Schell, Wiley A., A. M. Jones, Katyna Borroto-Esoda, and Barbara D. Alexander. “Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.Antimicrob Agents Chemother 61, no. 11 (November 2017). https://doi.org/10.1128/AAC.01102-17.
Schell WA, Jones AM, Borroto-Esoda K, Alexander BD. Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species. Antimicrob Agents Chemother. 2017 Nov;61(11).
Schell, Wiley A., et al. “Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.Antimicrob Agents Chemother, vol. 61, no. 11, Nov. 2017. Pubmed, doi:10.1128/AAC.01102-17.
Schell WA, Jones AM, Borroto-Esoda K, Alexander BD. Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species. Antimicrob Agents Chemother. 2017 Nov;61(11).

Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

November 2017

Volume

61

Issue

11

Location

United States

Related Subject Headings

  • Voriconazole
  • Triterpenes
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Glycosides
  • Echinocandins
  • Drug Resistance, Fungal
  • Candida
  • Antifungal Agents