Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.
Journal Article (Journal Article)
SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.
Full Text
Duke Authors
Cited Authors
- Schell, WA; Jones, AM; Borroto-Esoda, K; Alexander, BD
Published Date
- November 2017
Published In
Volume / Issue
- 61 / 11
PubMed ID
- 28827419
Pubmed Central ID
- PMC5655100
Electronic International Standard Serial Number (EISSN)
- 1098-6596
Digital Object Identifier (DOI)
- 10.1128/AAC.01102-17
Language
- eng
Conference Location
- United States