Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.

Journal Article (Journal Article)

SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.

Full Text

Duke Authors

Cited Authors

  • Schell, WA; Jones, AM; Borroto-Esoda, K; Alexander, BD

Published Date

  • November 2017

Published In

Volume / Issue

  • 61 / 11

PubMed ID

  • 28827419

Pubmed Central ID

  • PMC5655100

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.01102-17


  • eng

Conference Location

  • United States