Response of zonal chondrocytes to extracellular matrix-hydrogels.
Journal Article (Journal Article)
We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular microenvironment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses.
Full Text
Duke Authors
Cited Authors
- Hwang, NS; Varghese, S; Lee, HJ; Theprungsirikul, P; Canver, A; Sharma, B; Elisseeff, J
Published Date
- September 4, 2007
Published In
Volume / Issue
- 581 / 22
Start / End Page
- 4172 - 4178
PubMed ID
- 17692846
Pubmed Central ID
- PMC2692751
International Standard Serial Number (ISSN)
- 0014-5793
Digital Object Identifier (DOI)
- 10.1016/j.febslet.2007.07.049
Language
- eng
Conference Location
- England