Response of zonal chondrocytes to extracellular matrix-hydrogels.

Journal Article (Journal Article)

We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular microenvironment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses.

Full Text

Duke Authors

Cited Authors

  • Hwang, NS; Varghese, S; Lee, HJ; Theprungsirikul, P; Canver, A; Sharma, B; Elisseeff, J

Published Date

  • September 4, 2007

Published In

Volume / Issue

  • 581 / 22

Start / End Page

  • 4172 - 4178

PubMed ID

  • 17692846

Pubmed Central ID

  • PMC2692751

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2007.07.049


  • eng

Conference Location

  • England