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Response of zonal chondrocytes to extracellular matrix-hydrogels.

Publication ,  Journal Article
Hwang, NS; Varghese, S; Lee, HJ; Theprungsirikul, P; Canver, A; Sharma, B; Elisseeff, J
Published in: FEBS Lett
September 4, 2007
Published version (DOI) Link to item

We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular microenvironment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses.

Duke Scholars

Shyni Varghese
Author Shyni Varghese Orthopaedic Surgery
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Published In

FEBS Lett

DOI

10.1016/j.febslet.2007.07.049

ISSN

0014-5793

Publication Date

September 4, 2007

Volume

581

Issue

22

Start / End Page

4172 / 4178

Location

England

Related Subject Headings

  • Lubrication
  • Hydrogels
  • Glycosaminoglycans
  • Gene Expression Regulation
  • Extracellular Matrix Proteins
  • Extracellular Matrix
  • Chondrocytes
  • Cell Size
  • Cell Shape
  • Cell Separation
 

Citation

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Hwang, N. S., Varghese, S., Lee, H. J., Theprungsirikul, P., Canver, A., Sharma, B., & Elisseeff, J. (2007). Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Lett, 581(22), 4172–4178. https://doi.org/10.1016/j.febslet.2007.07.049
Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Parnduangjai Theprungsirikul, Adam Canver, Blanka Sharma, and Jennifer Elisseeff. “Response of zonal chondrocytes to extracellular matrix-hydrogels.” FEBS Lett 581, no. 22 (September 4, 2007): 4172–78. https://doi.org/10.1016/j.febslet.2007.07.049.
Hwang NS, Varghese S, Lee HJ, Theprungsirikul P, Canver A, Sharma B, et al. Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Lett. 2007 Sep 4;581(22):4172–8.
Hwang, Nathaniel S., et al. “Response of zonal chondrocytes to extracellular matrix-hydrogels.” FEBS Lett, vol. 581, no. 22, Sept. 2007, pp. 4172–78. Pubmed, doi:10.1016/j.febslet.2007.07.049.
Hwang NS, Varghese S, Lee HJ, Theprungsirikul P, Canver A, Sharma B, Elisseeff J. Response of zonal chondrocytes to extracellular matrix-hydrogels. FEBS Lett. 2007 Sep 4;581(22):4172–4178.
Journal cover image

Published In

FEBS Lett

DOI

10.1016/j.febslet.2007.07.049

ISSN

0014-5793

Publication Date

September 4, 2007

Volume

581

Issue

22

Start / End Page

4172 / 4178

Location

England

Related Subject Headings

  • Lubrication
  • Hydrogels
  • Glycosaminoglycans
  • Gene Expression Regulation
  • Extracellular Matrix Proteins
  • Extracellular Matrix
  • Chondrocytes
  • Cell Size
  • Cell Shape
  • Cell Separation