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Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.

Publication ,  Journal Article
Bolton, JL; Wiley, MG; Ryan, B; Truong, S; Strait, M; Baker, DC; Yang, NY; Ilkayeva, O; O'Connell, TM; Wroth, SW; Sánchez, CL; Swamy, G ...
Published in: Brain Behav
October 2017

INTRODUCTION: The role of perinatal diet in postpartum maternal mood disorders, including depression and anxiety, remains unclear. We investigated whether perinatal consumption of a Western-type diet (high in fat and branched-chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A). METHODS: Mouse dams were fed one of four diets (high-fat/high BCAA, low-fat/high BCAA, high-fat, and low-fat) prior to mating and throughout gestation and lactation. Postpartum behavioral assessments were conducted, and plasma and brain tissues assayed. To evaluate potential clinical utility, we conducted preliminary human studies using data from an extant sample of 17 primiparous women with high GWG, comparing across self-reported postpartum mood symptoms using the Edinburgh Postnatal Depression Scale (EPDS) for percent GWG and plasma amino acid levels. RESULTS: Mouse dams fed the high-fat/high BCAA diet gained more weight per kcal consumed, and BCAA-supplemented dams lost weight more slowly postpartum. Dams on BCAA-supplemented diets exhibited increased PPD/A-like behavior, decreased dopaminergic function, and decreased plasma tyrosine and histidine levels when assessed on postnatal day (P)8. Preliminary human data showed that GWG accounted for 29% of the variance in EPDS scores. Histidine was also lower in women with higher EPDS scores. CONCLUSIONS: These findings highlight the role of perinatal diet and excess GWG in the development of postpartum mood disorders.

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Published In

Brain Behav

DOI

EISSN

2162-3279

Publication Date

October 2017

Volume

7

Issue

10

Start / End Page

e00828

Location

United States

Related Subject Headings

  • Weight Gain
  • Tyrosine
  • Statistics as Topic
  • Puerperal Disorders
  • Psychiatric Status Rating Scales
  • Pregnancy
  • Postpartum Period
  • Mice
  • Humans
  • Histidine
 

Citation

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Bolton, J. L., Wiley, M. G., Ryan, B., Truong, S., Strait, M., Baker, D. C., … Simmons, L. A. (2017). Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood. Brain Behav, 7(10), e00828. https://doi.org/10.1002/brb3.828
Bolton, Jessica L., Melanie G. Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y. Yang, et al. “Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.Brain Behav 7, no. 10 (October 2017): e00828. https://doi.org/10.1002/brb3.828.
Bolton JL, Wiley MG, Ryan B, Truong S, Strait M, Baker DC, et al. Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood. Brain Behav. 2017 Oct;7(10):e00828.
Bolton, Jessica L., et al. “Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.Brain Behav, vol. 7, no. 10, Oct. 2017, p. e00828. Pubmed, doi:10.1002/brb3.828.
Bolton JL, Wiley MG, Ryan B, Truong S, Strait M, Baker DC, Yang NY, Ilkayeva O, O’Connell TM, Wroth SW, Sánchez CL, Swamy G, Newgard C, Kuhn C, Bilbo SD, Simmons LA. Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood. Brain Behav. 2017 Oct;7(10):e00828.
Journal cover image

Published In

Brain Behav

DOI

EISSN

2162-3279

Publication Date

October 2017

Volume

7

Issue

10

Start / End Page

e00828

Location

United States

Related Subject Headings

  • Weight Gain
  • Tyrosine
  • Statistics as Topic
  • Puerperal Disorders
  • Psychiatric Status Rating Scales
  • Pregnancy
  • Postpartum Period
  • Mice
  • Humans
  • Histidine