Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

Journal Article (Journal Article;Review)

For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration theory, but modern medical priorities and regulatory policies have resulted in tragic underutilization of the acquired knowledge.

Full Text

Duke Authors

Cited Authors

  • Villeneuve, C; Kou, HH; Eckermann, H; Palkar, A; Anderson, LG; McKenney, EA; Bollinger, RR; Parker, W

Published Date

  • March 2018

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 147 - 155

PubMed ID

  • 29133248

Electronic International Standard Serial Number (EISSN)

  • 1769-714X

Digital Object Identifier (DOI)

  • 10.1016/j.micinf.2017.11.001


  • eng

Conference Location

  • France