Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.

Journal Article (Journal Article)

A series of 3-heteroaryloxy4-phenyl-2-5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Therien, Michael J.

Cited Authors

Lau, CK; Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Ethier, D; Gauthier, JY; Gordon, R; Guay, J; Kargman, S; Li, CS; Prasit, P; Riendeau, D; Thérien, M; Visco, DM; Xu, L

Published Date

November 1999

Published In

Bioorganic & Medicinal Chemistry Letters

Volume / Issue

9 / 22

Start / End Page

3187 - 3192

PubMed ID

10576685

Electronic International Standard Serial Number (EISSN)

1464-3405

International Standard Serial Number (ISSN)

0960-894X

Digital Object Identifier (DOI)

10.1016/s0960-894x(99)00560-0

Language

eng