Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Publication
, Journal Article
Lau, CK; Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Ethier, D; Gauthier, JY; Gordon, R; Guay, J; Kargman, S; Li, CS; Prasit, P; Xu, L ...
Published in: Bioorganic & medicinal chemistry letters
November 1999
A series of 3-heteroaryloxy4-phenyl-2-5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
Duke Scholars
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 1999
Volume
9
Issue
22
Start / End Page
3187 / 3192
Related Subject Headings
- Rats
- Pyridines
- Prostaglandin-Endoperoxide Synthases
- Membrane Proteins
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Humans
- Furans
- Cyclooxygenase Inhibitors
- Cyclooxygenase 2 Inhibitors
Citation
APA
Chicago
ICMJE
MLA
NLM
Lau, C. K., Brideau, C., Chan, C. C., Charleson, S., Cromlish, W. A., Ethier, D., … Xu, L. (1999). Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry Letters, 9(22), 3187–3192. https://doi.org/10.1016/s0960-894x(99)00560-0
Lau, C. K., C. Brideau, C. C. Chan, S. Charleson, W. A. Cromlish, D. Ethier, J. Y. Gauthier, et al. “Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters 9, no. 22 (November 1999): 3187–92. https://doi.org/10.1016/s0960-894x(99)00560-0.
Lau CK, Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, et al. Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. Bioorganic & medicinal chemistry letters. 1999 Nov;9(22):3187–92.
Lau, C. K., et al. “Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters, vol. 9, no. 22, Nov. 1999, pp. 3187–92. Epmc, doi:10.1016/s0960-894x(99)00560-0.
Lau CK, Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, Gauthier JY, Gordon R, Guay J, Kargman S, Li CS, Prasit P, Riendeau D, Thérien M, Visco DM, Xu L. Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. Bioorganic & medicinal chemistry letters. 1999 Nov;9(22):3187–3192.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 1999
Volume
9
Issue
22
Start / End Page
3187 / 3192
Related Subject Headings
- Rats
- Pyridines
- Prostaglandin-Endoperoxide Synthases
- Membrane Proteins
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Humans
- Furans
- Cyclooxygenase Inhibitors
- Cyclooxygenase 2 Inhibitors