A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.
Li, CS; Black, WC; Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Claveau, D; Gauthier, JY; Gordon, R; Greig, G; Grimm, E; Guay, J; Lau, CK; Riendeau, D; Thérien, M; Visco, DM; Wong, E; Xu, L; Prasit, P
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