A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Published
Journal Article
By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.
Full Text
Duke Authors
Cited Authors
- Li, CS; Black, WC; Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Claveau, D; Gauthier, JY; Gordon, R; Greig, G; Grimm, E; Guay, J; Lau, CK; Riendeau, D; Thérien, M; Visco, DM; Wong, E; Xu, L; Prasit, P
Published Date
- November 1999
Published In
Volume / Issue
- 9 / 22
Start / End Page
- 3181 - 3186
PubMed ID
- 10576684
Pubmed Central ID
- 10576684
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/s0960-894x(99)00559-4
Language
- eng