A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Publication
, Journal Article
Li, CS; Black, WC; Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Claveau, D; Gauthier, JY; Gordon, R; Greig, G; Grimm, E; Guay, J; Xu, L ...
Published in: Bioorganic & medicinal chemistry letters
November 1999
By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.
Duke Scholars
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 1999
Volume
9
Issue
22
Start / End Page
3181 / 3186
Related Subject Headings
- Structure-Activity Relationship
- Rats
- Prostaglandin-Endoperoxide Synthases
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Furans
- Cyclooxygenase Inhibitors
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase 2
- Cricetinae
Citation
APA
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ICMJE
MLA
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Li, C. S., Black, W. C., Brideau, C., Chan, C. C., Charleson, S., Cromlish, W. A., … Prasit, P. (1999). A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters, 9(22), 3181–3186. https://doi.org/10.1016/s0960-894x(99)00559-4
Li, C. S., W. C. Black, C. Brideau, C. C. Chan, S. Charleson, W. A. Cromlish, D. Claveau, et al. “A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters 9, no. 22 (November 1999): 3181–86. https://doi.org/10.1016/s0960-894x(99)00559-4.
Li CS, Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, et al. A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters. 1999 Nov;9(22):3181–6.
Li, C. S., et al. “A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters, vol. 9, no. 22, Nov. 1999, pp. 3181–86. Epmc, doi:10.1016/s0960-894x(99)00559-4.
Li CS, Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Thérien M, Visco DM, Wong E, Xu L, Prasit P. A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters. 1999 Nov;9(22):3181–3186.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
November 1999
Volume
9
Issue
22
Start / End Page
3181 / 3186
Related Subject Headings
- Structure-Activity Relationship
- Rats
- Prostaglandin-Endoperoxide Synthases
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Furans
- Cyclooxygenase Inhibitors
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase 2
- Cricetinae