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Cross-spectral factor analysis

Publication ,  Conference
Gallagher, NM; Ulrich, K; Talbot, A; Dzirasa, K; Carin, L; Carlson, DE
Published in: Advances in Neural Information Processing Systems
January 1, 2017

In neuropsychiatric disorders such as schizophrenia or depression, there is often a disruption in the way that regions of the brain synchronize with one another. To facilitate understanding of network-level synchronization between brain regions, we introduce a novel model of multisite low-frequency neural recordings, such as local field potentials (LFPs) and electroencephalograms (EEGs). The proposed model, named Cross-Spectral Factor Analysis (CSFA), breaks the observed signal into factors defined by unique spatio-spectral properties. These properties are granted to the factors via a Gaussian process formulation in a multiple kernel learning framework. In this way, the LFP signals can be mapped to a lower dimensional space in a way that retains information of relevance to neuroscientists. Critically, the factors are interpretable. The proposed approach empirically allows similar performance in classifying mouse genotype and behavioral context when compared to commonly used approaches that lack the interpretability of CSFA. We also introduce a semi-supervised approach, termed discriminative CSFA (dCSFA). CSFA and dCSFA provide useful tools for understanding neural dynamics, particularly by aiding in the design of causal follow-up experiments.

Duke Scholars

Published In

Advances in Neural Information Processing Systems

ISSN

1049-5258

Publication Date

January 1, 2017

Volume

2017-December

Start / End Page

6843 / 6853

Related Subject Headings

  • 4611 Machine learning
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gallagher, N. M., Ulrich, K., Talbot, A., Dzirasa, K., Carin, L., & Carlson, D. E. (2017). Cross-spectral factor analysis. In Advances in Neural Information Processing Systems (Vol. 2017-December, pp. 6843–6853).
Gallagher, N. M., K. Ulrich, A. Talbot, K. Dzirasa, L. Carin, and D. E. Carlson. “Cross-spectral factor analysis.” In Advances in Neural Information Processing Systems, 2017-December:6843–53, 2017.
Gallagher NM, Ulrich K, Talbot A, Dzirasa K, Carin L, Carlson DE. Cross-spectral factor analysis. In: Advances in Neural Information Processing Systems. 2017. p. 6843–53.
Gallagher, N. M., et al. “Cross-spectral factor analysis.” Advances in Neural Information Processing Systems, vol. 2017-December, 2017, pp. 6843–53.
Gallagher NM, Ulrich K, Talbot A, Dzirasa K, Carin L, Carlson DE. Cross-spectral factor analysis. Advances in Neural Information Processing Systems. 2017. p. 6843–6853.

Published In

Advances in Neural Information Processing Systems

ISSN

1049-5258

Publication Date

January 1, 2017

Volume

2017-December

Start / End Page

6843 / 6853

Related Subject Headings

  • 4611 Machine learning
  • 1702 Cognitive Sciences
  • 1701 Psychology