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The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.

Publication ,  Journal Article
Zhao, X; Liu, X; Zhang, A; Chen, H; Huo, Q; Li, W; Ye, R; Chen, Z; Liang, L; Liu, QA; Shen, J; Jin, X; Li, W; Nygaard, M; Liu, X; Hou, Y ...
Published in: Aging
June 2018

Copy number variations (CNVs) have been shown to cause numerous diseases, however, their roles in human lifespan remain elusive. In this study, we investigate the association of CNVs with longevity by comparing the Han Chinese genomes of long-lived individuals from 90 to 117 years of age and the middle-aged from 30 to 65. Our data demonstrate that the numbers of CNVs, especially deletions, increase significantly in a direct correlation with longevity. We identify eleven CNVs that strongly associate with longevity; four of them locate in the chromosome bands, 7p11.2, 20q13.33, 19p12 and 8p23.3 and overlap partially with the CNVs identified in long-lived Danish or U.S. populations, while the other seven have not been reported previously. These CNV regions encode nineteen known genes, and some of which have been shown to affect aging-related phenotypes such as the shortening of telomere length (ZNF208), the risk of cancer (FOXA1, LAMA5, ZNF716), and vascular and immune-related diseases (ARHGEF10, TOR2A, SH2D3C). In addition, we found several pathways enriched in long-lived genomes, including FOXA1 and FOXA transcription factor networks involved in regulating aging or age-dependent diseases such as cancer. Thus, our study has identified longevity-associated CNV regions and their affected genes and pathways. Our results suggest that the human genome structures such as CNVs might play an important role in determining a long life in human.

Duke Scholars

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Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

June 2018

Volume

10

Issue

6

Start / End Page

1206 / 1222

Related Subject Headings

  • Male
  • Longevity
  • Humans
  • Genome-Wide Association Study
  • Genome
  • Gene Expression Regulation
  • Female
  • Developmental Biology
  • DNA Copy Number Variations
  • Asian People
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, X., Liu, X., Zhang, A., Chen, H., Huo, Q., Li, W., … Nie, C. (2018). The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging, 10(6), 1206–1222. https://doi.org/10.18632/aging.101461
Zhao, Xin, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.Aging 10, no. 6 (June 2018): 1206–22. https://doi.org/10.18632/aging.101461.
Zhao X, Liu X, Zhang A, Chen H, Huo Q, Li W, et al. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging. 2018 Jun;10(6):1206–22.
Zhao, Xin, et al. “The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.Aging, vol. 10, no. 6, June 2018, pp. 1206–22. Epmc, doi:10.18632/aging.101461.
Zhao X, Liu X, Zhang A, Chen H, Huo Q, Li W, Ye R, Chen Z, Liang L, Liu QA, Shen J, Jin X, Nygaard M, Hou Y, Ni T, Bolund L, Gottschalk W, Tao W, Gu J, Tian X-L, Yang H, Wang J, Xu X, Lutz MW, Min J, Zeng Y, Nie C. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging. 2018 Jun;10(6):1206–1222.

Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

June 2018

Volume

10

Issue

6

Start / End Page

1206 / 1222

Related Subject Headings

  • Male
  • Longevity
  • Humans
  • Genome-Wide Association Study
  • Genome
  • Gene Expression Regulation
  • Female
  • Developmental Biology
  • DNA Copy Number Variations
  • Asian People