Skip to main content
Journal cover image

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Publication ,  Journal Article
Bottiger, BA; Nicoara, A; Snyder, LD; Wischmeyer, PE; Schroder, JN; Patel, CB; Daneshmand, MA; Sladen, RN; Ghadimi, K
Published in: J Cardiothorac Vasc Anesth
May 2019

The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary failure may be under consideration for heart or lung transplantation along with bridging therapies such as ventricular assist device implantation or venovenous extracorporeal membrane oxygenation, respectively. Early identification of frail patients in an attempt to modify the risk of postoperative morbidity and mortality has become an important area of study over the last decade. Many quantification tools and risk prediction models for frailty have been developed but have not been evaluated extensively or standardized in the cardiothoracic transplant candidate population. Heightened awareness of frailty, coupled with a better understanding of distinct cellular mechanisms and biomarkers apart from end-stage organ disease, may play an important role in potentially reversing frailty related to organ failure. Furthermore, the clinical management of these critically ill patients may be enhanced by waitlist and postoperative physical rehabilitation and nutritional optimization.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Cardiothorac Vasc Anesth

DOI

EISSN

1532-8422

Publication Date

May 2019

Volume

33

Issue

5

Start / End Page

1382 / 1392

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Perioperative Care
  • Lung Transplantation
  • Lung Diseases
  • Humans
  • Heart Transplantation
  • Heart Failure
  • Frailty
  • Anesthesiology
  • Age Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bottiger, B. A., Nicoara, A., Snyder, L. D., Wischmeyer, P. E., Schroder, J. N., Patel, C. B., … Ghadimi, K. (2019). Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician. J Cardiothorac Vasc Anesth, 33(5), 1382–1392. https://doi.org/10.1053/j.jvca.2018.08.002
Bottiger, Brandi A., Alina Nicoara, Laurie D. Snyder, Paul E. Wischmeyer, Jacob N. Schroder, Chetan B. Patel, Mani A. Daneshmand, Robert N. Sladen, and Kamrouz Ghadimi. “Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.J Cardiothorac Vasc Anesth 33, no. 5 (May 2019): 1382–92. https://doi.org/10.1053/j.jvca.2018.08.002.
Bottiger BA, Nicoara A, Snyder LD, Wischmeyer PE, Schroder JN, Patel CB, et al. Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician. J Cardiothorac Vasc Anesth. 2019 May;33(5):1382–92.
Bottiger, Brandi A., et al. “Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.J Cardiothorac Vasc Anesth, vol. 33, no. 5, May 2019, pp. 1382–92. Pubmed, doi:10.1053/j.jvca.2018.08.002.
Bottiger BA, Nicoara A, Snyder LD, Wischmeyer PE, Schroder JN, Patel CB, Daneshmand MA, Sladen RN, Ghadimi K. Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician. J Cardiothorac Vasc Anesth. 2019 May;33(5):1382–1392.
Journal cover image

Published In

J Cardiothorac Vasc Anesth

DOI

EISSN

1532-8422

Publication Date

May 2019

Volume

33

Issue

5

Start / End Page

1382 / 1392

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Perioperative Care
  • Lung Transplantation
  • Lung Diseases
  • Humans
  • Heart Transplantation
  • Heart Failure
  • Frailty
  • Anesthesiology
  • Age Factors