Scholars@Duke

• Background
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  Education, Training, & Certifications

  • M.D., Pennsylvania State University 2006
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  Previous Appointments & Affiliations

  • Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2019 - 2020
  • Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2011 - 2019
• Research
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  External Relationships

  • CSL Behring LLC
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Courtwright, Andrew M., Jagan Devarajan, Ashley Virginia Fritz, Archer Kilbourne Martin, Barbara Wilkey, Sudhakar Subramani, Christopher M. Cassara, et al. “Cardiothoracic Transplant Anesthesia: Selected Highlights: Part I-Lung Transplantation.” J Cardiothorac Vasc Anesth 37, no. 6 (June 2023): 884–903. https://doi.org/10.1053/j.jvca.2023.01.023.
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    • Mamoun, Negmeldeen, Brandi Bottiger, Mary Cooter Wright, Rebecca Klinger, Ashley Grantham, Bryant Stolp, Sergio Bustamante, and Mark Stafford-Smith. “Effectiveness of Simulation- Versus Didactic Video-Based Learning to Teach Advanced Lung Isolation Techniques.” J Cardiothorac Vasc Anesth 37, no. 5 (May 2023): 767–73. https://doi.org/10.1053/j.jvca.2022.12.016.
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    • Halpern, Samantha E., Mary C. Wright, Gabrielle Madsen, Bryan Chow, Chelsea S. Harris, John C. Haney, Jacob A. Klapper, Brandi A. Bottiger, and Matthew G. Hartwig. “Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension.” J Heart Lung Transplant 41, no. 11 (November 2022): 1628–37. https://doi.org/10.1016/j.healun.2022.07.015.
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    • Loor, Gabriel, Stephen Huddleston, Matthew Hartwig, Brandi Bottiger, Daoud Daoud, Qi Wei, Qianzi Zhang, et al. “Effect of mode of intraoperative support on primary graft dysfunction after lung transplant.” J Thorac Cardiovasc Surg 164, no. 5 (November 2022): 1351-1361.e4. https://doi.org/10.1016/j.jtcvs.2021.10.076.
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    • Mamoun, Negmeldeen, Mary Cooter Wright, Brandi Bottiger, Ryan Plichta, Rebecca Klinger, Michael Manning, Karthik Raghunathan, and Padma Gulur. “Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.” J Cardiothorac Vasc Anesth 36, no. 9 (September 2022): 3596–3602. https://doi.org/10.1053/j.jvca.2022.05.007.
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    • Courtwright, Andrew M., Barbara Wilkey, Jagan Devarajan, Sudhakar Subramani, Archer Kilbourne Martin, Ashley Virginia Fritz, Christopher M. Cassara, et al. “The Year in Cardiothoracic Transplant Anesthesia: Selected Highlights From 2020 Part I - Lung Transplantation.” J Cardiothorac Vasc Anesth 36, no. 1 (January 2022): 33–44. https://doi.org/10.1053/j.jvca.2021.09.013.
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    • Ghadimi, Kamrouz, Jhaymie Cappiello, Mary Cooter-Wright, John C. Haney, John M. Reynolds, Brandi A. Bottiger, Jacob A. Klapper, Jerrold H. Levy, Matthew G. Hartwig, and Matthew G. INSPIRE-FLO Investigators. “Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.” Jama Surg 157, no. 1 (January 1, 2022): e215856. https://doi.org/10.1001/jamasurg.2021.5856.
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    • Klapper, Jacob A., Anne C. Hicks, Leila Ledbetter, Jessica Poisson, Matthew G. Hartwig, Nazish Hashmi, Ian Welsby, and Brandi A. Bottiger. “Blood product transfusion and lung transplant outcomes: A systematic review.” Clin Transplant 35, no. 10 (October 2021): e14404. https://doi.org/10.1111/ctr.14404.
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    • Boisen, Michael L., Travis Schisler, Lavinia Kolarczyk, Vladyslav Melnyk, Noah Rolleri, Brandi Bottiger, Rebecca Klinger, Emily Teeter, Vidya K. Rao, and Theresa A. Gelzinis. “Corrigendum to 'The Year in Thoracic Anesthesia: Selected Highlights from 2019' [Journal of Cardiothoracic and Vascular Anesthesia 34 (2020) 1733-1744].” J Cardiothorac Vasc Anesth 35, no. 1 (January 2021): 343. https://doi.org/10.1053/j.jvca.2020.06.085.
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    • Bottiger, Brandi A., Jacob Klapper, Angela Pollak, and Ian Welsby. “When Therapy Is Confounded With Approach: Retrospective Studies of Transfusion-Related Outcomes After Lung Transplantation.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3021–23. https://doi.org/10.1053/j.jvca.2020.07.064.
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    • Seay, Theresa, Nicole Guinn, Yasmin Maisonave, Matt Fuller, Jessica Poisson, Angela Pollak, Ben Bryner, et al. “The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3024–32. https://doi.org/10.1053/j.jvca.2020.05.043.
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    • Bottiger, Brandi A., Katayoun Aghajani, Madhav Swaminathan, and Alina Nicoara. “Intraoperative Assessment and Significance of Diastolic Mitral Regurgitation by Transesophageal Echocardiography.” A a Pract 14, no. 11 (September 2020): e01290. https://doi.org/10.1213/XAA.0000000000001290.
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    • Barac, Yaron D., Jacob Klapper, Angela Pollack, Jessica Poisson, Ian Welsby, M. G. Hartwig, and Brandi Bottiger. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant.” Ann Thorac Surg 110, no. 1 (July 2020): e23–25. https://doi.org/10.1016/j.athoracsur.2019.11.056.
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    • Boisen, Michael L., Travis Schisler, Lavinia Kolarczyk, Vladyslav Melnyk, Noah Rolleri, Brandi Bottiger, Rebecca Klinger, Emily Teeter, Vidya K. Rao, and Theresa A. Gelzinis. “The Year in Thoracic Anesthesia: Selected Highlights from 2019.” J Cardiothorac Vasc Anesth 34, no. 7 (July 2020): 1733–44. https://doi.org/10.1053/j.jvca.2020.03.016.
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    • Klinger, Rebecca Y., Brandi Bottiger, and Miles Berger. “A Plague on Both Your Monitors! Are Bispectral Index and Cerebral Oximetry Useful for Reducing Postoperative Cognitive Impairment?” J Cardiothorac Vasc Anesth 34, no. 5 (May 2020): 1182–83. https://doi.org/10.1053/j.jvca.2020.01.001.
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    • Klinger, Rebecca Y., Claire Cunniff, Negmeldeen Mamoun, Mary Cooter, Nazish Hashmi, Thomas Hopkins, Patrick Smith, Matthew Hartwig, and Brandi Bottiger. “Patient-Reported Chronic Pain Outcomes After Lung Transplantation.” Semin Cardiothorac Vasc Anesth 24, no. 1 (March 2020): 96–103. https://doi.org/10.1177/1089253219882432.
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    • Pena, Joseph J., Brandi A. Bottiger, and Andrea N. Miltiades. “Perioperative Management of Bleeding and Transfusion for Lung Transplantation.” Semin Cardiothorac Vasc Anesth 24, no. 1 (March 2020): 74–83. https://doi.org/10.1177/1089253219869030.
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    • Bottiger, Brandi A., Alina Nicoara, Laurie D. Snyder, Paul E. Wischmeyer, Jacob N. Schroder, Chetan B. Patel, Mani A. Daneshmand, Robert N. Sladen, and Kamrouz Ghadimi. “Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.” J Cardiothorac Vasc Anesth 33, no. 5 (May 2019): 1382–92. https://doi.org/10.1053/j.jvca.2018.08.002.
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    • Alenezi, Fawaz, Marat Fudim, Jennifer Rymer, Allison Dunning, Karen Chiswell, Madhav Swaminathan, Brandi Bottiger, et al. “Predictors and Changes in Cardiac Hemodynamics and Geometry With Transcatheter Aortic Valve Implantation.” Am J Cardiol 123, no. 5 (March 1, 2019): 813–19. https://doi.org/10.1016/j.amjcard.2018.11.038.
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    • Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.
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    • Teeter, Emily G., Claire Dakik, Mary Cooter, Zainab Samad, Kamrouz Ghadimi, J Kevin Harrison, Jeffery Gaca, Mark Stafford-Smith, and Brandi A. Bottiger. “Assessment of Paravalvular Leak After Transcatheter Aortic Valve Replacement: Transesophageal Echocardiography Compared With Transthoracic Echocardiography.” J Cardiothorac Vasc Anesth 31, no. 4 (August 2017): 1278–84. https://doi.org/10.1053/j.jvca.2017.03.010.
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    • Yalamuri, Suraj, Rebecca Y. Klinger, W Michael Bullock, Donald D. Glower, Brandi A. Bottiger, and Jeffrey C. Gadsden. “Pectoral Fascial (PECS) I and II Blocks as Rescue Analgesia in a Patient Undergoing Minimally Invasive Cardiac Surgery.” Reg Anesth Pain Med 42, no. 6 (2017): 764–66. https://doi.org/10.1097/AAP.0000000000000661.
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    • Plakke, Michael J., Cory D. Maxwell, and Brandi A. Bottiger. “Intraoperative Monitoring of Pulmonary Artery Physiology With Transesophageal Echocardiography in a Patient With an Extensive Pulmonary Aneurysm Undergoing Partial Nephrectomy.” A a Case Rep 7, no. 5 (September 1, 2016): 108–11. https://doi.org/10.1213/XAA.0000000000000359.
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    • Bottiger, Brandi A., Dmitri S. Bezinover, Berend Mets, Priti G. Dalal, Jansie Prozesky, Serdar Ural, and Sonia Vaida. “Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?” J Anaesthesiol Clin Pharmacol 32, no. 3 (2016): 319–24. https://doi.org/10.4103/0970-9185.168159.
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    • Esper, Stephen A., Brandi A. Bottiger, Brian Ginsberg, J Mauricio Del Rio, Donald D. Glower, Jeffrey G. Gaca, Mark Stafford-Smith, Peter J. Neuburger, and Mark A. Chaney. “CASE 8--2015. Paravertebral Catheter-Based Strategy for Primary Analgesia After Minimally Invasive Cardiac Surgery.” J Cardiothorac Vasc Anesth 29, no. 4 (August 2015): 1071–80. https://doi.org/10.1053/j.jvca.2015.02.018.
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    • Dallas, Torijaun, Ian Welsby, Brandi Bottiger, Carmelo Milano, Mani Daneshmand, and Nicole Guinn. “Bloodless Orthotopic Heart Transplantation in a Jehovah's Witness.” A a Case Rep 4, no. 10 (May 15, 2015): 140–42. https://doi.org/10.1213/XAA.0000000000000067.
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    • Bottiger, Brandi, Sharon McCartney, Igor Akushevich, Alina Nicoara, Mamata Yanamadala, and Madhav Swaminathan. “Use of mobile tablet devices and reduction in time to perioperative transesophageal echocardiography reporting: a historical cohort study.” Can J Anaesth 62, no. 1 (January 2015): 31–36. https://doi.org/10.1007/s12630-014-0250-6.
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    • Bottiger, Brandi A., Stephen A. Esper, and Mark Stafford-Smith. “Pain management strategies for thoracotomy and thoracic pain syndromes.” Semin Cardiothorac Vasc Anesth 18, no. 1 (March 2014): 45–56. https://doi.org/10.1177/1089253213514484.
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    • Bottiger, Brandi A., Robert D. Davis, Robert C. Swift, and Madhav Swaminathan. “Aortic stenosis and coronary artery disease... and a challenging aorta.” J Cardiothorac Vasc Anesth 25, no. 2 (April 2011): 368–69. https://doi.org/10.1053/j.jvca.2011.01.005.
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  • Conference Papers

    • Subramaniam, Kathirvel, Gabriel Loor, Ernest G. Chan, Brandi A. Bottiger, Fabio Ius, Matthew G. Hartwig, Daoud Daoud, et al. “Intraoperative Red Blood Cell Transfusion and Primary Graft Dysfunction After Lung Transplantation.” In Transplantation, 2023. https://doi.org/10.1097/TP.0000000000004545.
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    • Halpern, S. E., M. C. Wright, G. Madsen, B. Chow, J. C. Haney, J. A. Klapper, B. A. Bottiger, and M. G. Hartwig. “Textbook Outcome in Lung Transplantation: Planned VA ECMO versus Off-Pump.” In American Journal of Transplantation, 22:989–989, 2022.
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    • Pontula, A., S. E. Halpern, B. A. Bottiger, J. C. Haney, J. A. Klapper, and M. G. Hartwig. “Comparing the Paragonix LUNGguard Donor Lung Preservation System to Traditional Ice Storage.” In Journal of Heart and Lung Transplantation, 41:S257–S257, 2022.
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    • Halpern, Samantha E., Sandra Au, Samuel J. Kesseli, Madison K. Krischak, Danae G. Olaso, Brandi A. Bottiger, John C. Haney, Jacob A. Klapper, and Matthew G. Hartwig. “Lung transplantation using allografts with more than 8 hours of ischemic time: A single-institution experience.” In J Heart Lung Transplant, 40:1463–71, 2021. https://doi.org/10.1016/j.healun.2021.05.008.
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    • Bottiger, B. A., K. Subramaniam, F. Ius, G. Warnecke, M. Hartwig, G. Loor, D. Daoud, et al. “Characteristics of Bilateral Orthotopic Lung Transplant Patients that Develop Severe Perioperative Acute Kidney Injury.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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    • Ghadimi, K., J. Cappiello, M. Cooter, J. Haney, J. Reynolds, B. A. Bottiger, J. Klapper, B. McLendon-Arvik, J. H. Levy, and M. G. Hartwig. “Inhaled Selective Pulmonary Vasodilators for Adult Lung Transplantation.” In Journal of Heart and Lung Transplantation, 40:S75–S75, 2021.
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    • Hartwig, M., G. Loor, B. Bottiger, G. Warnecke, W. Sommer, A. Frick, A. Neyrinck, et al. “Effect of Time of Intraoperative Circulatory Support on Incidence of High-Grade Primary Graft Dysfunction (PGD): Multicenter Analysis on Use of Extracorporeal Life Support (ECLS) during Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S328–29, 2020. https://doi.org/10.1016/j.healun.2020.01.346.
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    • Najmeh, S., J. Klapper, J. Poisson, M. Fuller, L. Zaffiri, J. Haney, M. Hartwig, et al. “Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S317, 2020. https://doi.org/10.1016/j.healun.2020.01.715.
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    • Pollak, A. L., J. Poisson, M. Cooter, Y. D. Barac, B. Bryner, J. Haney, M. G. Hartwig, et al. “Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S330, 2020. https://doi.org/10.1016/j.healun.2020.01.349.
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    • Villavicencio-Theoduloz, M., M. A. Kashem, M. Hartwig, G. Loor, G. Warnecke, I. Tudorache, D. Van Raemdonck, et al. “Effect of Cold Ischemic Time on the Incidence of High-Grade Primary Graft Dysfunction (PGD): A Multicenter Analysis.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S329, 2020. https://doi.org/10.1016/j.healun.2020.01.347.
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    • Rajagopal, K., M. A. Daneshmand, M. A. Schechter, A. M. Ganapathi, C. B. Patel, J. G. Rogers, B. A. Bottiger, M. Swaminathan, and C. A. Milano. “767 Impact of Left Ventricular Assist Device Implantation upon Native Aortic Valve Regurgitation.” In The Journal of Heart and Lung Transplantation, 31:S261–62. Elsevier BV, 2012. https://doi.org/10.1016/j.healun.2012.01.783.
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