Scholars@Duke
Brandi Anne Bottiger

Brandi Anne Bottiger

Associate Professor of Anesthesiology
Anesthesiology, Cardiothoracic

Selected Publications

Transfusions in Lung Transplantation: Reply.

Journal Article Anesthesiology · December 1, 2024 Full text Link to item Cite

The Year in Cardiothoracic Transplant Anesthesia: Selected Highlights From 2022 Part I: Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · November 2024 These highlights focus on the research in lung transplantation (LTX) that was published in 2022 and includes the assessment and optimization of candidates for LTX, donor optimization, the use of organs from donation after circulatory death, and outcomes wh ... Full text Link to item Cite

ISHLT consensus statement on the perioperative use of ECLS in lung transplantation: Part II: Intraoperative considerations.

Journal Article J Heart Lung Transplant · October 9, 2024 The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examin ... Full text Link to item Cite

The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding.

Journal Article J Cardiothorac Surg · July 25, 2024 BACKGROUND: Lung transplantation (LT) represents a high-risk procedure for end-stage lung diseases. This study describes the outcomes of patients undergoing LT that require massive transfusions as defined by the universal definition of perioperative bleedi ... Full text Link to item Cite

Pain trajectories after bilateral orthotopic lung transplantation surgery performed via a clamshell incision.

Journal Article Clin Transplant · February 2024 INTRODUCTION: The nature, intensity, and progression of acute pain after bilateral orthotopic lung transplantation (BOLT) performed via a clamshell incision has not been well investigated. We aimed to describe acute pain after clamshell incisions using pai ... Full text Link to item Cite

PERSUADE Survey-PERioperative AnestheSia and Intensive Care Management of Left VentricUlar Assist DevicE Implantation in Europe and the United States.

Journal Article J Cardiothorac Vasc Anesth · January 2024 OBJECTIVE: To comprehensively assess relevant institutional variations in anesthesia and intensive care management during left ventricular assist device (LVAD) implantation. DESIGN: The authors used a prospective data analysis. SETTING: This was an online ... Full text Link to item Cite

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery.

Journal Article Circulation · October 24, 2023 BACKGROUND: Right ventricular failure (RVF) is a leading driver of morbidity and death after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation. Inhaled pulmonary-sel ... Full text Open Access Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

Intraoperative Red Blood Cell Transfusion and Primary Graft Dysfunction After Lung Transplantation.

Conference Transplantation · July 1, 2023 BACKGROUND: In this international, multicenter study of patients undergoing lung transplantation (LT), we explored the association between the amount of intraoperative packed red blood cell (PRBC) transfusion and occurrence of primary graft dysfunction (PG ... Full text Link to item Cite

Effectiveness of Simulation- Versus Didactic Video-Based Learning to Teach Advanced Lung Isolation Techniques.

Journal Article J Cardiothorac Vasc Anesth · May 2023 OBJECTIVES: Mastery of lung isolation is crucial for optimal cardiothoracic anesthesia education. The authors tested the hypothesis that simulation- is more effective than didactic video-based learning (cognitive, affective, and psychomotor) to teach anest ... Full text Link to item Cite

Anesthesia and Hemodynamic Management for Lung Transplantation

Chapter · January 1, 2023 This chapter discusses the key preoperative considerations, intraoperative management strategies for lung transplantation as it pertains to induction of anesthesia, airway management, hemodynamic management, and postoperative analgesic strategies, with a r ... Full text Cite

Effect of mode of intraoperative support on primary graft dysfunction after lung transplant.

Journal Article J Thorac Cardiovasc Surg · November 2022 OBJECTIVE: To clarify the relationship between the use of extracorporeal life support during lung transplantation and severe primary graft dysfunction (PGD), we developed and analyzed a novel multicenter international registry. METHODS: The Extracorporeal ... Full text Link to item Cite

Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension.

Journal Article J Heart Lung Transplant · November 2022 BACKGROUND: Planned venoarterial extracorporeal membrane oxygenation (VA ECMO) is increasingly used during bilateral orthotopic lung transplantation (BOLT) and may be superior to off-pump support for patients without pulmonary hypertension. In this single- ... Full text Link to item Cite

Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.

Journal Article J Cardiothorac Vasc Anesth · September 2022 OBJECTIVES: Controlling moderate-to-severe pain remains a major challenge after cardiothoracic surgery. Several outcomes have been compared extensively after valve surgery performed via midline sternotomy versus mini-thoracotomy, but postoperative pain (PO ... Full text Link to item Cite

The Year in Cardiothoracic Transplant Anesthesia: Selected Highlights From 2020 Part I - Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · January 2022 This special article focuses on the highlights in cardiothoracic transplantation literature in the year 2020. Part I encompasses the recent literature on lung transplantation, including the advances in preoperative assessment and optimization, donor manage ... Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal Article JAMA Surg · January 1, 2022 IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

Textbook Outcome in Lung Transplantation: Planned VA ECMO versus Off-Pump.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Lung transplantation using allografts with more than 8 hours of ischemic time: A single-institution experience.

Conference J Heart Lung Transplant · November 2021 BACKGROUND: Six hours was historically regarded as the limit of acceptable ischemic time for lung allografts. However, broader sharing of donor lungs often necessitates use of allografts with ischemic time >6 hours. We characterized the association between ... Full text Link to item Cite

Blood product transfusion and lung transplant outcomes: A systematic review.

Journal Article Clinical transplantation · October 2021 The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and aft ... Full text Cite

Inhaled Selective Pulmonary Vasodilators for Adult Lung Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

Journal Article J Cardiothorac Vasc Anesth · November 2020 OBJECTIVES: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product require ... Full text Link to item Cite

Anticoagulation Strategies in the Perioperative Period for Lung Transplant.

Journal Article Ann Thorac Surg · July 2020 Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to re ... Full text Link to item Cite

The Year in Thoracic Anesthesia: Selected Highlights from 2019.

Journal Article J Cardiothorac Vasc Anesth · July 2020 THIS special article is the 4th in an annual series for the Journal of Cardiothoracic and Vascular Anesthesia. The authors thank the editor-in-chief, Dr. Kaplan; the associate editor-in-chief, Dr. Augoustides; and the editorial board for the opportunity to ... Full text Link to item Cite

Effect of Time of Intraoperative Circulatory Support on Incidence of High-Grade Primary Graft Dysfunction (PGD): Multicenter Analysis on Use of Extracorporeal Life Support (ECLS) during Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Prior single center experiences suggest that use of ECLS during lung transplantation (LT) increases the risk of PGD. Here we analyze the effects of intraoperative ECLS time on PGD after LT in a multicenter ECLS registry. METHODS: The ECLS in LT re ... Full text Cite

Effect of Cold Ischemic Time on the Incidence of High-Grade Primary Graft Dysfunction (PGD): A Multicenter Analysis

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Prior studies have explored the effects of cold ischemic time on survival but its effect on PGD is unclear. The current study analyzed an international multicenter ECLS in lung transplantation registry to clarify the effects of cold ischemic time ... Full text Cite

Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Transfusion during lung transplantation (LT) is linked to primary graft dysfunction (PGD) and worsened outcomes. Goal-directed protocols have improved outcomes in cardiac surgical populations and decreased transfusions in LT on cardiopulmonary byp ... Full text Cite

Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Blood transfusion during lung transplantation (LT) surgery is common. There is little evidence to identify potential candidates for transfusion-free LT surgery. We describe patient and procedural characteristics of LT patients in the era of ECMO a ... Full text Cite

Perioperative Management of Bleeding and Transfusion for Lung Transplantation.

Journal Article Semin Cardiothorac Vasc Anesth · March 2020 Perioperative allogeneic blood product transfusion is common in lung transplantation and has various implications on the short- and long-term outcomes of lung recipients. This review summarizes the effect of transfusion on outcomes including primary graft ... Full text Open Access Link to item Cite

Patient-Reported Chronic Pain Outcomes After Lung Transplantation.

Journal Article Semin Cardiothorac Vasc Anesth · March 2020 Chronic pain after lung transplantation is a significant concern, in particular given the heterogeneity of the patient population and the challenges of achieving adequate pain control amid concerns related to complex immunosuppressant regimens and the poss ... Full text Link to item Cite

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Journal Article J Cardiothorac Vasc Anesth · May 2019 The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary f ... Full text Open Access Link to item Cite

Predictors and Changes in Cardiac Hemodynamics and Geometry With Transcatheter Aortic Valve Implantation.

Journal Article Am J Cardiol · March 1, 2019 The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Assessment of Paravalvular Leak After Transcatheter Aortic Valve Replacement: Transesophageal Echocardiography Compared With Transthoracic Echocardiography.

Journal Article J Cardiothorac Vasc Anesth · August 2017 OBJECTIVES: Determine whether moderate or greater paravalvular leak (PVL) after transcatheter aortic valve replacement quantified using intraoperative transesophageal echocardiography (TEE) is associated with mortality and investigate the correlation betwe ... Full text Link to item Cite

Pectoral Fascial (PECS) I and II Blocks as Rescue Analgesia in a Patient Undergoing Minimally Invasive Cardiac Surgery.

Journal Article Reg Anesth Pain Med · 2017 INTRODUCTION: Patients undergoing minimally invasive cardiac surgery have the potential for significant pain from the thoracotomy site. We report the successful use of pectoral nerve block types I and II (Pecs I and II) as rescue analgesia in a patient und ... Full text Link to item Cite

Intraoperative Monitoring of Pulmonary Artery Physiology With Transesophageal Echocardiography in a Patient With an Extensive Pulmonary Aneurysm Undergoing Partial Nephrectomy.

Journal Article A A Case Rep · September 1, 2016 Surgical patients with pulmonary hypertension present a significant challenge to the anesthesiologist. Continuous perioperative monitoring of pulmonary artery (PA) pressure is recommended and most often accomplished with a PA catheter. Placement of a PA ca ... Full text Link to item Cite

Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?

Journal Article J Anaesthesiol Clin Pharmacol · 2016 BACKGROUND AND AIMS: Patients undergoing elective cesarean delivery (CD) have a high-risk of spinal-induced hypotension (SIH). We hypothesized that a colloid preload would further reduce SIH when compared with a crystalloid preload. MATERIAL AND METHODS: E ... Full text Link to item Cite

Bloodless Orthotopic Heart Transplantation in a Jehovah's Witness.

Journal Article A A Case Rep · May 15, 2015 We present the case of a 53-year-old female Jehovah's Witness with nonischemic cardiomyopathy who successfully underwent a bloodless heart transplantation using fibrinogen concentrate (RiaSTAP; CSL Behring, King of Prussia, PA) and other blood-conservation ... Full text Link to item Cite

Use of mobile tablet devices and reduction in time to perioperative transesophageal echocardiography reporting: a historical cohort study.

Journal Article Can J Anaesth · January 2015 PURPOSE: Timely communication of intraoperative transesophageal echocardiography (TEE) findings to the postoperative care team is critical to optimizing patient care. We compared the use of a personal computer (PC) system with the use of a mobile tablet de ... Full text Open Access Link to item Cite

Pain management strategies for thoracotomy and thoracic pain syndromes.

Journal Article Semin Cardiothorac Vasc Anesth · March 2014 Pain after thoracic surgery can be severe and, in the acute phase, contribute to perioperative morbidity and mortality. Unfortunately, patients also incur a significant risk of chronic pain. Although there are guidelines for postoperative pain management i ... Full text Link to item Cite

767 Impact of Left Ventricular Assist Device Implantation upon Native Aortic Valve Regurgitation

Conference The Journal of Heart and Lung Transplantation · April 2012 Full text Cite