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Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?

Publication ,  Journal Article
Bottiger, BA; Bezinover, DS; Mets, B; Dalal, PG; Prozesky, J; Ural, S; Vaida, S
Published in: J Anaesthesiol Clin Pharmacol
2016

BACKGROUND AND AIMS: Patients undergoing elective cesarean delivery (CD) have a high-risk of spinal-induced hypotension (SIH). We hypothesized that a colloid preload would further reduce SIH when compared with a crystalloid preload. MATERIAL AND METHODS: Eighty-two healthy parturients undergoing elective CD were included in the study. Patients were randomly assigned to two groups (41 patients in each group) to receive either Lactated Ringer's solution (1500 ml) or hydroxyethyl starch (6% in normal saline, 500 ml) 30 min prior to placement of spinal anesthesia. All patients were treated with a phenylephrine infusion (100 mcg/min), titrated during the study. RESULTS: There was no statistical difference between groups with regards to the incidence of hypotension (10.8% in the colloid group vs. 27.0% in the crystalloid group, P = 0.12). There was also no difference between groups with respect to bradycardia, APGAR scores, and nausea and vomiting. Significantly less phenylephrine (1077.5 ± 514 mcg) was used in the colloid group than the crystalloid group (1477 ± 591 mcg, P = 0.003). CONCLUSION: The preload with 6% of hydroxyethyl starch before CD might be beneficial for the prevention of SIH.

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Published In

J Anaesthesiol Clin Pharmacol

DOI

ISSN

0970-9185

Publication Date

2016

Volume

32

Issue

3

Start / End Page

319 / 324

Location

India

Related Subject Headings

  • Anesthesiology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences
 

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Bottiger, B. A., Bezinover, D. S., Mets, B., Dalal, P. G., Prozesky, J., Ural, S., & Vaida, S. (2016). Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference? J Anaesthesiol Clin Pharmacol, 32(3), 319–324. https://doi.org/10.4103/0970-9185.168159
Bottiger, Brandi A., Dmitri S. Bezinover, Berend Mets, Priti G. Dalal, Jansie Prozesky, Serdar Ural, and Sonia Vaida. “Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?J Anaesthesiol Clin Pharmacol 32, no. 3 (2016): 319–24. https://doi.org/10.4103/0970-9185.168159.
Bottiger BA, Bezinover DS, Mets B, Dalal PG, Prozesky J, Ural S, et al. Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference? J Anaesthesiol Clin Pharmacol. 2016;32(3):319–24.
Bottiger, Brandi A., et al. “Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?J Anaesthesiol Clin Pharmacol, vol. 32, no. 3, 2016, pp. 319–24. Pubmed, doi:10.4103/0970-9185.168159.
Bottiger BA, Bezinover DS, Mets B, Dalal PG, Prozesky J, Ural S, Vaida S. Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference? J Anaesthesiol Clin Pharmacol. 2016;32(3):319–324.

Published In

J Anaesthesiol Clin Pharmacol

DOI

ISSN

0970-9185

Publication Date

2016

Volume

32

Issue

3

Start / End Page

319 / 324

Location

India

Related Subject Headings

  • Anesthesiology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences