M1 and M2 immune activation in Parkinson's Disease: Foe and ally?
Journal Article (Journal Article;Review)
Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disorder of unknown etiology. Autopsy findings, genetics, retrospective studies, and molecular imaging all suggest a role for inflammation in the neurodegenerative process. However, relatively little is understood about the causes and implications of neuroinflammation in PD. Understanding how inflammation arises in PD, in particular the activation state of cells of the innate immune system, may provide an exciting opportunity for novel neuroprotective therapeutics. We analyze the evidence of immune system involvement in PD susceptibility, specifically in the context of M1 and M2 activation states. Tracking and modulating these activation states may provide new insights into both PD etiology and therapeutic strategies.
Full Text
Duke Authors
Cited Authors
- Moehle, MS; West, AB
Published Date
- August 27, 2015
Published In
Volume / Issue
- 302 /
Start / End Page
- 59 - 73
PubMed ID
- 25463515
Pubmed Central ID
- PMC4442748
Electronic International Standard Serial Number (EISSN)
- 1873-7544
Digital Object Identifier (DOI)
- 10.1016/j.neuroscience.2014.11.018
Language
- eng
Conference Location
- United States