Andrew Bradley West | Scholars@Duke

Andrew Bradley West
Professor of Pharmacology and Cancer Biology

Current Research Interests

The West lab focuses on identifying critical pathogenic mechanisms underlying neurological diseases like Parkinson’s disease with the goal of developing new therapeutics to block disease progression. The West lab is housed in the brand-new Duke Center for Neurodegeneration and Neurotherapeutics and works with clinicians in the discovery of biomarkers for disease progression and therapeutic responses together with basic neuroscientists in defining pathways in neurons and immune cells that drive disease.

Current Appointments & Affiliations

Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2020
Professor in the Department of Neurology, Neurology, Behavioral Neurology, Neurology 2021

Contact Information

3 Genome Court, MSRB III 5th Fl, Durham, NC 27710
MSRB III 5124, DUMC 103853, Durham, NC 27710
andrew.west@duke.edu (919) 684-1656
West Laboratory Website

Background
Education, Training, & Certifications
- Ph.D., Mayo Clinic 2003
Previous Appointments & Affiliations
- Consulting Professor in the Department of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2018 - 2019
Expertise
Subject Headings
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Mechanisms of LRRK2 Mediated Neurotoxicity awarded by National Institutes of Health 2018 - 2026
- Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Role of enteroendocrine cells in the origin of Parkinson's pathology awarded by Michael J. Fox Foundation for Parkinson's Research 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Role of Rab10 in Alzheimer's disease awarded by National Institutes of Health 2022 - 2024
- Urate-LLRK2 interactions in Parkinson's disease awarded by Massachusetts General Hospital 2019 - 2023
- Innate and Adaptive Immunity in Parkinson Disease; Project 3: PD-linked Genetic Susceptibilities in Macrophage Responses awarded by University of Alabama at Birmingham 2018 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Characterization and functional analysis of PPMI LRRK2 variants awarded by Michael J. Fox Foundation for Parkinson's Research 2018 - 2021
- Efficacies and Pharmacodynamic Assays for LRRk2 Small-Molecule Inhibitors awarded by National Institutes of Health 2018 - 2020
- Exosome LRRK2 in Predicting Parkinson Disease Phenotypes awarded by National Institutes of Health 2018 - 2019
External Relationships
- E-Scape Bio
- Michael J. Fox Foundation for Parkinson's Research
- Neuro23, Inc.
Publications & Artistic Works
Selected Publications
- Books
  - Moore, Darren J., Andrew B. West, Valina L. Dawson, and Ted M. Dawson. Molecular pathophysiology of Parkinson's disease. Vol. 28, 2005. https://doi.org/10.1146/annurev.neuro.28.061604.135718.
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- Academic Articles
  - Niotis, Kellyann, Andrew B. West, and Rachel Saunders-Pullman. “Who to Enroll in Parkinson Disease Prevention Trials? The Case for Genetically At-Risk Cohorts.” Neurology 99, no. 7 Suppl 1 (August 16, 2022): 10–18. https://doi.org/10.1212/WNL.0000000000200812.
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  - Wang, Shijie, Shakthi Unnithan, Nicole Bryant, Allison Chang, Liana S. Rosenthal, Alexander Pantelyat, Ted M. Dawson, Hussein R. Al-Khalidi, and Andrew B. West. “Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.” Mov Disord 37, no. 7 (July 2022): 1454–64. https://doi.org/10.1002/mds.29043.
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  - Xu, Enquan, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, et al. “Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.” Mol Neurodegener 17, no. 1 (January 10, 2022): 7. https://doi.org/10.1186/s13024-021-00509-5.
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  - Hastings, Lyndsay, Arpine Sokratian, Daniel J. Apicco, Christina M. Stanhope, Lindsey Smith, Warren D. Hirst, Andrew B. West, and Kaela Kelly. “Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration.” Brain Commun 4, no. 2 (2022): fcac042. https://doi.org/10.1093/braincomms/fcac042.
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  - Brzozowski, Charlotte F., Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, and Laura A. Volpicelli-Daley. “Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.” Acta Neuropathol Commun 9, no. 1 (November 8, 2021): 180. https://doi.org/10.1186/s40478-021-01283-7.
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  - Abdelmotilib, Hisham, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, et al. “Corrigendum to "α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration" [Neurobiol. Dis., Volume 105 (2017) Article 84, 98].” Neurobiol Dis 159 (November 2021): 105506. https://doi.org/10.1016/j.nbd.2021.105506.
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  - Brzozowski, Charlotte F., Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, and Laura A. Volpicelli-Daley. “Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein,” October 5, 2021. https://doi.org/10.1101/2021.10.04.463043.
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  - Kelly, Kaela, Allison Chang, Lyndsay Hastings, Hisham Abdelmotilib, and Andrew B. West. “Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain.” Brain Res 1759 (May 15, 2021): 147372. https://doi.org/10.1016/j.brainres.2021.147372.
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  - Tokarew, Jacqueline M., Daniel N. El-Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela P. Nguyen, Bojan Shutinoski, Brian O’Nuallain, et al. “Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.” Acta Neuropathol 141, no. 5 (May 2021): 725–54. https://doi.org/10.1007/s00401-021-02285-4.
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  - Bryant, Nicole, Nicole Malpeli, Julia Ziaee, Cornelis Blauwendraat, Zhiyong Liu, Zhiyong AMP PD Consortium, and Andrew B. West. “Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.” Hum Mol Genet 30, no. 6 (April 30, 2021): 454–66. https://doi.org/10.1093/hmg/ddab058.
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  - Carlisle, Samantha M., Hongwei Qin, R Curtis Hendrickson, Jordana E. Muwanguzi, Elliot J. Lefkowitz, Richard E. Kennedy, Zhaoqi Yan, et al. “Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease.” Npj Parkinsons Dis 7, no. 1 (April 13, 2021): 36. https://doi.org/10.1038/s41531-021-00180-z.
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  - Ortega, Roberto A., Cuiling Wang, Deborah Raymond, Nicole Bryant, Clemens R. Scherzer, Avner Thaler, Roy N. Alcalay, et al. “Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.” Jama Netw Open 4, no. 4 (April 1, 2021): e215845. https://doi.org/10.1001/jamanetworkopen.2021.5845.
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  - Sokratian, Arpine, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, et al. “Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.” Acta Neuropathol 141, no. 4 (April 2021): 547–64. https://doi.org/10.1007/s00401-021-02288-1.
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  - Kline, Elizabeth M., Madelyn C. Houser, Mary K. Herrick, Philip Seibler, Christine Klein, Andrew West, and Malú G. Tansey. “Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.” Mov Disord 36, no. 1 (January 2021): 25–36. https://doi.org/10.1002/mds.28411.
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  - Wang, Shijie, Kaela Kelly, Jonathan M. Brotchie, James B. Koprich, and Andrew B. West. “Exosome markers of LRRK2 kinase inhibition.” Npj Parkinsons Dis 6, no. 1 (November 13, 2020): 32. https://doi.org/10.1038/s41531-020-00138-7.
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  - Liu, Zhiyong, Enquan Xu, Hien Tran Zhao, Tracy Cole, and Andrew B. West. “LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.” Embo J 39, no. 20 (October 15, 2020): e104862. https://doi.org/10.15252/embj.2020104862.
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  - Kelly, K., and A. B. West. “Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics.” Frontiers in Neuroscience 14 (August 6, 2020). https://doi.org/10.3389/fnins.2020.00807.
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  - Nguyen, An Phu Tran, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore. “Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.” Proc Natl Acad Sci U S A 117, no. 29 (July 21, 2020): 17296–307. https://doi.org/10.1073/pnas.1922184117.
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  - Tan, Eng-King, Yin-Xia Chao, Andrew West, Ling-Ling Chan, Werner Poewe, and Joseph Jankovic. “Parkinson disease and the immune system - associations, mechanisms and therapeutics.” Nat Rev Neurol 16, no. 6 (June 2020): 303–18. https://doi.org/10.1038/s41582-020-0344-4.
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  - Liu, Zhiyong, Enquan Xu, Hien Tran Zhao, Tracy Cole, and Andrew West. “LRRK2 and Rab10 Coordinate Macropinocytosis to Mediate Immunological Responses in Phagocytes,” 2020. https://doi.org/10.1101/2020.01.30.926840.
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  - Wang, Shijie, Kaela Kelly, Nathalie Schussler, Sylviane Boularand, Laurent Dubois, Frank Hsieh, Elizabeth Tengstrand, Jonathan Brotchie, James Koprich, and Andrew West. “Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids,” 2020. https://doi.org/10.1101/2020.01.28.923557.
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  - Wang, Shijie, Kyoko Kojima, James A. Mobley, and Andrew B. West. “Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease.” Ebiomedicine 45 (July 2019): 351–61. https://doi.org/10.1016/j.ebiom.2019.06.021.
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  - Wang, Shijie, and Andrew B. West. “Caught in the act: LRRK2 in exosomes.” Biochem Soc Trans 47, no. 2 (April 30, 2019): 663–70. https://doi.org/10.1042/BST20180467.
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  - Cresto, Noémie, Camille Gardier, Francesco Gubinelli, Marie-Claude Gaillard, Géraldine Liot, Andrew B. West, and Emmanuel Brouillet. “The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.” Eur J Neurosci 49, no. 3 (February 2019): 339–63. https://doi.org/10.1111/ejn.14182.
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  - Kelly, Kaela, Shijie Wang, Ravindra Boddu, Zhiyong Liu, Omar Moukha-Chafiq, Corinne Augelli-Szafran, and Andrew B. West. “The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.” Exp Neurol 309 (November 2018): 1–13. https://doi.org/10.1016/j.expneurol.2018.07.012.
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  - Delic, Vedad, Sidhanth Chandra, Hisham Abdelmotilib, Tyler Maltbie, Shijie Wang, Danielle Kem, Hunter J. Scott, et al. “Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies.” J Comp Neurol 526, no. 12 (August 15, 2018): 1978–90. https://doi.org/10.1002/cne.24468.
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  - Chen-Plotkin, Alice S., Roger Albin, Roy Alcalay, Debra Babcock, Vikram Bajaj, Dubois Bowman, Alex Buko, et al. “Finding useful biomarkers for Parkinson's disease.” Sci Transl Med 10, no. 454 (August 15, 2018). https://doi.org/10.1126/scitranslmed.aam6003.
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  - Liu, Zhiyong, Nicole Bryant, Ravindran Kumaran, Alexandra Beilina, Asa Abeliovich, Mark R. Cookson, and Andrew B. West. “LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.” Hum Mol Genet 27, no. 2 (January 15, 2018): 385–95. https://doi.org/10.1093/hmg/ddx410.
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  - West, Andrew B. “Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.” Exp Neurol 298, no. Pt B (December 2017): 236–45. https://doi.org/10.1016/j.expneurol.2017.07.019.
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  - Wang, Shijie, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly, and Andrew B. West. “Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.” Acta Neuropathol Commun 5, no. 1 (November 22, 2017): 86. https://doi.org/10.1186/s40478-017-0492-y.
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  - Harms, Ashley S., Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite, and Andrew B. West. “α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.” Acta Neuropathol Commun 5, no. 1 (November 21, 2017): 85. https://doi.org/10.1186/s40478-017-0494-9.
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  - Abdelmotilib, Hisham, and Andrew B. West. “Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy.” Genome Med 9, no. 1 (October 19, 2017): 88. https://doi.org/10.1186/s13073-017-0483-4.
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  - Zhao, Hien Tran, Neena John, Vedad Delic, Karli Ikeda-Lee, Aneeza Kim, Andreas Weihofen, Eric E. Swayze, Holly B. Kordasiewicz, Andrew B. West, and Laura A. Volpicelli-Daley. “LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.” Mol Ther Nucleic Acids 8 (September 15, 2017): 508–19. https://doi.org/10.1016/j.omtn.2017.08.002.
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  - Abdelmotilib, Hisham, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, et al. “α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.” Neurobiol Dis 105 (September 2017): 84–98. https://doi.org/10.1016/j.nbd.2017.05.014.
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  - Ivanova, Anna A., Tamara Caspary, Nicholas T. Seyfried, Duc M. Duong, Andrew B. West, Zhiyong Liu, and Richard A. Kahn. “Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).” J Biol Chem 292, no. 26 (June 30, 2017): 11091–108. https://doi.org/10.1074/jbc.M117.784025.
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  - Gwinn, Katrina, Karen K. David, Christine Swanson-Fischer, Roger Albin, Coryse St Hillaire-Clarke, Beth-Anne Sieber, Codrin Lungu, et al. “Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.” Biomark Med 11, no. 6 (May 2017): 451–73. https://doi.org/10.2217/bmm-2016-0370.
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  - Liu, Zhiyong, and Andrew B. West. “The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.” Biochim Biophys Acta Proteins Proteom 1865, no. 3 (March 2017): 274–80. https://doi.org/10.1016/j.bbapap.2016.12.001.
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  - Cook, D. A., G. T. Kannarkat, A. F. Cintron, Laura M. Butkovich, Kyle B. Fraser, J. Chang, N. Grigoryan, et al. “LRRK2 levels in immune cells are increased in Parkinson's disease.” Npj Parkinsons Dis 3 (2017): 11. https://doi.org/10.1038/s41531-017-0010-8.
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  - Ellis, Shannon E., Simone Gupta, Anna Moes, Andrew B. West, and Dan E. Arking. “Exaggerated CpH methylation in the autism-affected brain.” Mol Autism 8 (2017): 6. https://doi.org/10.1186/s13229-017-0119-y.
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  - Fraser, Kyle B., Ashlee B. Rawlins, Rachel G. Clark, Roy N. Alcalay, David G. Standaert, Nianjun Liu, Nianjun Parkinson’s Disease Biomarker Program Consortium, and Andrew B. West. “Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease.” Mov Disord 31, no. 10 (October 2016): 1543–50. https://doi.org/10.1002/mds.26686.
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  - West, Andrew B., and Mark R. Cookson. “Identification of bona-fide LRRK2 kinase substrates.” Mov Disord 31, no. 8 (August 2016): 1140–41. https://doi.org/10.1002/mds.26647.
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  - Volpicelli-Daley, Laura A., Hisham Abdelmotilib, Zhiyong Liu, Lindsay Stoyka, João Paulo Lima Daher, Austen J. Milnerwood, Vivek K. Unni, et al. “G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.” J Neurosci 36, no. 28 (July 13, 2016): 7415–27. https://doi.org/10.1523/JNEUROSCI.3642-15.2016.
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  - Rosenthal, Liana S., Daniel Drake, Roy N. Alcalay, Debra Babcock, F DuBois Bowman, Alice Chen-Plotkin, Ted M. Dawson, et al. “The NINDS Parkinson's disease biomarkers program.” Mov Disord 31, no. 6 (June 2016): 915–23. https://doi.org/10.1002/mds.26438.
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  - Ellis, S. E., R. Panitch, A. B. West, and D. E. Arking. “Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia.” Transl Psychiatry 6 (May 24, 2016): e817. https://doi.org/10.1038/tp.2016.87.
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  - Fraser, Kyle B., Mark S. Moehle, Roy N. Alcalay, Andrew B. West, and Andrew B. LRRK2 Cohort Consortium. “Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.” Neurology 86, no. 11 (March 15, 2016): 994–99. https://doi.org/10.1212/WNL.0000000000002436.
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  - Lavalley, Nicholas J., Sunny R. Slone, Huiping Ding, Andrew B. West, and Talene A. Yacoubian. “14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.” Hum Mol Genet 25, no. 1 (January 1, 2016): 109–22. https://doi.org/10.1093/hmg/ddv453.
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  - Liu, Zhiyong, James A. Mobley, Lawrence J. DeLucas, Richard A. Kahn, and Andrew B. West. “LRRK2 autophosphorylation enhances its GTPase activity.” Faseb J 30, no. 1 (January 2016): 336–47. https://doi.org/10.1096/fj.15-277095.
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  - Moehle, M. S., and A. B. West. “M1 and M2 immune activation in Parkinson's Disease: Foe and ally?” Neuroscience 302 (August 27, 2015): 59–73. https://doi.org/10.1016/j.neuroscience.2014.11.018.
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  - Daher, João P. L., Hisham A. Abdelmotilib, Xianzhen Hu, Laura A. Volpicelli-Daley, Mark S. Moehle, Kyle B. Fraser, Elie Needle, et al. “Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.” J Biol Chem 290, no. 32 (August 7, 2015): 19433–44. https://doi.org/10.1074/jbc.M115.660001.
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  - Moehle, Mark S., João Paulo Lima Daher, Travis D. Hull, Ravindra Boddu, Hisham A. Abdelmotilib, James Mobley, George T. Kannarkat, Malú G. Tansey, and Andrew B. West. “The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.” Hum Mol Genet 24, no. 15 (August 1, 2015): 4250–67. https://doi.org/10.1093/hmg/ddv157.
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  - Boddu, Ravindra, Travis D. Hull, Subhashini Bolisetty, Xianzhen Hu, Mark S. Moehle, João Paulo Lima Daher, Ahmed Ibrahim Kamal, et al. “Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.” Hum Mol Genet 24, no. 14 (July 15, 2015): 4078–93. https://doi.org/10.1093/hmg/ddv147.
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  - West, Andrew B. “Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinic.” Mov Disord 30, no. 2 (February 2015): 180–89. https://doi.org/10.1002/mds.26075.
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  - Volpicelli-Daley, Laura A., Karen L. Gamble, Christine E. Schultheiss, Dawn M. Riddle, Andrew B. West, and Virginia M-Y Lee. “Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.” Mol Biol Cell 25, no. 25 (December 15, 2014): 4010–23. https://doi.org/10.1091/mbc.E14-02-0741.
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  - Gupta, Simone, Shannon E. Ellis, Foram N. Ashar, Anna Moes, Joel S. Bader, Jianan Zhan, Andrew B. West, and Dan E. Arking. “Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.” Nat Commun 5 (December 10, 2014): 5748. https://doi.org/10.1038/ncomms6748.
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  - Liu, Zhiyong, Robert A. Galemmo, Kyle B. Fraser, Mark S. Moehle, Saurabh Sen, Laura A. Volpicelli-Daley, Lawrence J. DeLucas, et al. “Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.” J Biol Chem 289, no. 47 (November 21, 2014): 32937–51. https://doi.org/10.1074/jbc.M114.602318.
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  - Lucas, Elizabeth K., Sarah E. Dougherty, Laura J. McMeekin, Courtney S. Reid, Lynn E. Dobrunz, Andrew B. West, John J. Hablitz, and Rita M. Cowell. “PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.” J Neurosci 34, no. 43 (October 22, 2014): 14375–87. https://doi.org/10.1523/JNEUROSCI.1222-14.2014.
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  - West, Andrew B., Rita M. Cowell, João P. L. Daher, Mark S. Moehle, Kelly M. Hinkle, Heather L. Melrose, David G. Standaert, and Laura A. Volpicelli-Daley. “Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.” J Comp Neurol 522, no. 11 (August 1, 2014): 2465–80. https://doi.org/10.1002/cne.23583.
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  - Daher, João P. L., Laura A. Volpicelli-Daley, Jonathan P. Blackburn, Mark S. Moehle, and Andrew B. West. “Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.” Proc Natl Acad Sci U S A 111, no. 25 (June 24, 2014): 9289–94. https://doi.org/10.1073/pnas.1403215111.
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  - Dougherty, S. E., J. J. Hollimon, L. J. McMeekin, A. S. Bohannon, A. B. West, M. Lesort, J. J. Hablitz, and R. M. Cowell. “Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.” Neurobiol Dis 62 (February 2014): 160–71. https://doi.org/10.1016/j.nbd.2013.10.002.
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  - Ellis, Shannon E., Simone Gupta, Foram N. Ashar, Joel S. Bader, Andrew B. West, and Dan E. Arking. “RNA-Seq optimization with eQTL gold standards.” Bmc Genomics 14 (December 17, 2013): 892. https://doi.org/10.1186/1471-2164-14-892.
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  - Fraser, Kyle B., Mark S. Moehle, João P. L. Daher, Philip J. Webber, Jeri Y. Williams, Carrie A. Stewart, Talene A. Yacoubian, et al. “LRRK2 secretion in exosomes is regulated by 14-3-3.” Hum Mol Genet 22, no. 24 (December 15, 2013): 4988–5000. https://doi.org/10.1093/hmg/ddt346.
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  - Davies, Paul, Kelly M. Hinkle, Nour N. Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R. Alessi, et al. “Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.” Biochem J 453, no. 1 (July 1, 2013): 101–13. https://doi.org/10.1042/BJ20121742.
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  - Sampath, Srirangan, Shambu Bhat, Simone Gupta, Ashley O’Connor, Andrew B. West, Dan E. Arking, and Aravinda Chakravarti. “Defining the contribution of CNTNAP2 to autism susceptibility.” Plos One 8, no. 10 (2013): e77906. https://doi.org/10.1371/journal.pone.0077906.
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  - Day, Kenneth, Lindsay L. Waite, Anna Thalacker-Mercer, Andrew West, Marcas M. Bamman, James D. Brooks, Richard M. Myers, and Devin Absher. “Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.” Genome Biol 14, no. 9 (2013): R102. https://doi.org/10.1186/gb-2013-14-9-r102.
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  - Moehle, Mark S., Philip J. Webber, Tonia Tse, Nour Sukar, David G. Standaert, Tara M. DeSilva, Rita M. Cowell, and Andrew B. West. “LRRK2 inhibition attenuates microglial inflammatory responses.” J Neurosci 32, no. 5 (February 1, 2012): 1602–11. https://doi.org/10.1523/JNEUROSCI.5601-11.2012.
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  - Stafa, Klodjan, Alzbeta Trancikova, Philip J. Webber, Liliane Glauser, Andrew B. West, and Darren J. Moore. “GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.” Plos Genet 8, no. 2 (2012): e1002526. https://doi.org/10.1371/journal.pgen.1002526.
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  - Trancikova, Alzbeta, Adamantios Mamais, Philip J. Webber, Klodjan Stafa, Elpida Tsika, Liliane Glauser, Andrew B. West, Rina Bandopadhyay, and Darren J. Moore. “Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.” Plos One 7, no. 10 (2012): e47784. https://doi.org/10.1371/journal.pone.0047784.
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  - Webber, Philip J., Archer D. Smith, Saurabh Sen, Matthew B. Renfrow, James A. Mobley, and Andrew B. West. “Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.” J Mol Biol 412, no. 1 (September 9, 2011): 94–110. https://doi.org/10.1016/j.jmb.2011.07.033.
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  - Andrabi, Shaida A., Ho Chul Kang, Jean-François Haince, Yun-Il Lee, Jian Zhang, Zhikai Chi, Andrew B. West, et al. “Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.” Nat Med 17, no. 6 (June 2011): 692–99. https://doi.org/10.1038/nm.2387.
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  - Looyenga, Brendan D., Kyle A. Furge, Karl J. Dykema, Julie Koeman, Pamela J. Swiatek, Thomas J. Giordano, Andrew B. West, James H. Resau, Bin T. Teh, and Jeffrey P. MacKeigan. “Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.” Proc Natl Acad Sci U S A 108, no. 4 (January 25, 2011): 1439–44. https://doi.org/10.1073/pnas.1012500108.
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  - Pungaliya, Pooja P., Yuchen Bai, Kerri Lipinski, Vasanti S. Anand, Saurabh Sen, Eugene L. Brown, Brian Bates, et al. “Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.” Plos One 5, no. 10 (October 27, 2010): e13672. https://doi.org/10.1371/journal.pone.0013672.
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  - Aasly, Jan O., Carles Vilariño-Güell, Justus C. Dachsel, Philip J. Webber, Andrew B. West, Kristoffer Haugarvoll, Krisztina K. Johansen, et al. “Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.” Mov Disord 25, no. 13 (October 15, 2010): 2156–63. https://doi.org/10.1002/mds.23265.
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  - Lee, Byoung Dae, Joo-Ho Shin, Jackalina VanKampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun-Il Lee, et al. “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.” Nat Med 16, no. 9 (September 2010): 998–1000. https://doi.org/10.1038/nm.2199.
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  - Sen, Saurabh, Philip J. Webber, and Andrew B. West. “Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.” J Biol Chem 284, no. 52 (December 25, 2009): 36346–56. https://doi.org/10.1074/jbc.M109.025437.
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  - Costa, Cristine Alves da, Claire Sunyach, Emilie Giaime, Andrew West, Olga Corti, Alexis Brice, Stephen Safe, et al. “Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.” Nat Cell Biol 11, no. 11 (November 2009): 1370–75. https://doi.org/10.1038/ncb1981.
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  - Webber, Philip J., and Andrew B. West. “LRRK2 in Parkinson's disease: function in cells and neurodegeneration.” Febs J 276, no. 22 (November 2009): 6436–44. https://doi.org/10.1111/j.1742-4658.2009.07342.x.
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  - Weiss, Lauren A., Dan E. Arking, Dan E. Gene Discovery Project of Johns Hopkins & the Autism Consortium, Mark J. Daly, and Aravinda Chakravarti. “A genome-wide linkage and association scan reveals novel loci for autism.” Nature 461, no. 7265 (October 8, 2009): 802–8. https://doi.org/10.1038/nature08490.
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  - Sen, Saurabh, and Andrew B. West. “The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.” Antioxid Redox Signal 11, no. 9 (September 2009): 2167–87. https://doi.org/10.1089/ars.2009.2430.
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  - Biskup, Saskia, and Andrew B. West. “Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.” Biochim Biophys Acta 1792, no. 7 (July 2009): 625–33. https://doi.org/10.1016/j.bbadis.2008.09.015.
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  - Dawson, Ted M., Darren J. Moore, and Andrew B. West. “Revelations and revolutions in the understanding of Parkinson's disease.” Biochim Biophys Acta 1792, no. 7 (July 2009): 585–86. https://doi.org/10.1016/j.bbadis.2009.06.001.
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  - Moore, Darren J., Andrew B. West, Dustin A. Dikeman, Valina L. Dawson, and Ted M. Dawson. “Parkin mediates the degradation-independent ubiquitination of Hsp70.” J Neurochem 105, no. 5 (June 2008): 1806–19. https://doi.org/10.1111/j.1471-4159.2008.05261.x.
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  - Biskup, Saskia, Darren J. Moore, Alexis Rea, Bettina Lorenz-Deperieux, Candice E. Coombes, Valina L. Dawson, Ted M. Dawson, and Andrew B. West. “Dynamic and redundant regulation of LRRK2 and LRRK1 expression.” Bmc Neurosci 8 (November 28, 2007): 102. https://doi.org/10.1186/1471-2202-8-102.
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  - Higashi, Shinji, Saskia Biskup, Andrew B. West, Daniel Trinkaus, Valina L. Dawson, Richard L. M. Faull, Henry J. Waldvogel, et al. “Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.” Brain Res 1155 (June 25, 2007): 208–19. https://doi.org/10.1016/j.brainres.2007.04.034.
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  - West, Andrew B., Darren J. Moore, Catherine Choi, Shaida A. Andrabi, Xiaojie Li, Dustin Dikeman, Saskia Biskup, et al. “Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.” Hum Mol Genet 16, no. 2 (January 15, 2007): 223–32. https://doi.org/10.1093/hmg/ddl471.
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  - Biskup, Saskia, Darren J. Moore, Fulvio Celsi, Shinji Higashi, Andrew B. West, Shaida A. Andrabi, Kaisa Kurkinen, et al. “Localization of LRRK2 to membranous and vesicular structures in mammalian brain.” Ann Neurol 60, no. 5 (November 2006): 557–69. https://doi.org/10.1002/ana.21019.
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  - Smith, Wanli W., Zhong Pei, Haibing Jiang, Darren J. Moore, Yideng Liang, Andrew B. West, Valina L. Dawson, Ted M. Dawson, and Christopher A. Ross. “Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.” Proc Natl Acad Sci U S A 102, no. 51 (December 20, 2005): 18676–81. https://doi.org/10.1073/pnas.0508052102.
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  - West, Andrew B., Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, and Ted M. Dawson. “Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.” Proc Natl Acad Sci U S A 102, no. 46 (November 15, 2005): 16842–47. https://doi.org/10.1073/pnas.0507360102.
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  - West, Andrew B., Valina L. Dawson, and Ted M. Dawson. “To die or grow: Parkinson's disease and cancer.” Trends Neurosci 28, no. 7 (July 2005): 348–52. https://doi.org/10.1016/j.tins.2005.05.002.
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  - West, Andrew B., Gregory Kapatos, Casey O’Farrell, Fanny Gonzalez-de-Chavez, Kelvin Chiu, Matthew J. Farrer, and Nigel T. Maidment. “N-myc regulates parkin expression.” J Biol Chem 279, no. 28 (July 9, 2004): 28896–902. https://doi.org/10.1074/jbc.M400126200.
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  - West, Andrew B., and Nigel T. Maidment. “Genetics of parkin-linked disease.” Hum Genet 114, no. 4 (March 2004): 327–36. https://doi.org/10.1007/s00439-003-1074-6.
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  - Lincoln, S., J. Wiley, T. Lynch, J. W. Langston, R. Chen, A. Lang, E. Rogaeva, et al. “Parkin-proven disease: common founders but divergent phenotypes.” Neurology 60, no. 10 (May 27, 2003): 1605–10. https://doi.org/10.1212/01.wnl.0000064289.49410.a9.
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  - West, Andrew B., Fanny Gonzalez-de-Chavez, Kristen Wilkes, Casey O’Farrell, and Matthew J. Farrer. “Parkin is not regulated by the unfolded protein response in human neuroblastoma cells.” Neurosci Lett 341, no. 2 (May 1, 2003): 139–42. https://doi.org/10.1016/s0304-3940(03)00188-5.
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  - West, Andrew B., Paul J. Lockhart, Casey O’Farell, and Matthew J. Farrer. “Identification of a novel gene linked to parkin via a bi-directional promoter.” J Mol Biol 326, no. 1 (February 7, 2003): 11–19. https://doi.org/10.1016/s0022-2836(02)01376-1.
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  - West, A., M. Periquet, S. Lincoln, C. B. Lucking, D. Nicholl, V. Bonifati, N. Rawal, et al. “Complex relationship between Parkin mutations and Parkinson disease (vol 114, pg 584, 2002).” American Journal of Medical Genetics 114, no. 8 (December 8, 2002): 992–992. https://doi.org/10.1002/ajmg.10918.
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  - West, A., M. Periquet, S. Lincoln, C. B. Lücking, D. Nicholl, V. Bonifati, N. Rawal, et al. “Erratum: Complex relationship between Parkin mutations and Parkinson disease (American Journal of Medical Genetics-Neuropsychocetric (2002) 114-(584-591)).” American Journal of Medical Genetics Neuropsychiatric Genetics 114, no. 8 (December 8, 2002): 992. https://doi.org/10.1002/ajmg.b.10918.
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  - West, Andrew B., Demetrius Maraganore, Julia Crook, Tim Lesnick, Paul J. Lockhart, Kristen M. Wilkes, Gregory Kapatos, John A. Hardy, and Matt J. Farrer. “Functional association of the parkin gene promoter with idiopathic Parkinson's disease.” Hum Mol Genet 11, no. 22 (October 15, 2002): 2787–92. https://doi.org/10.1093/hmg/11.22.2787.
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  - West, Andrew, Magali Periquet, Sarah Lincoln, Christoph B. Lücking, David Nicholl, Vincenzo Bonifati, Nina Rawal, et al. “Complex relationship between Parkin mutations and Parkinson disease.” Am J Med Genet 114, no. 5 (July 8, 2002): 584–91. https://doi.org/10.1002/ajmg.10525.
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  - Wu, Ruey-Meei, Din-E Shan, Chen-Ming Sun, Ren-Shyan Liu, Wuh-Liang Hwu, Chun-Hwei Tai, Jennifer Hussey, et al. “Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations.” Mov Disord 17, no. 4 (July 2002): 670–75. https://doi.org/10.1002/mds.10184.
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  - West, A. B., A. Zimprich, P. J. Lockhart, M. Farrer, A. Singleton, B. Holtom, S. Lincoln, et al. “Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.” Eur J Hum Genet 9, no. 9 (September 2001): 659–66. https://doi.org/10.1038/sj.ejhg.5200698.
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  - West, A., M. Farrer, L. Petrucelli, M. Cookson, P. Lockhart, and J. Hardy. “Identification and characterization of the human parkin gene promoter.” J Neurochem 78, no. 5 (September 2001): 1146–52. https://doi.org/10.1046/j.1471-4159.2001.00512.x.
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  - Farrer, M., D. M. Maraganore, P. Lockhart, A. Singleton, T. G. Lesnick, M. de Andrade, A. West, R. de Silva, J. Hardy, and D. Hernandez. “alpha-Synuclein gene haplotypes are associated with Parkinson's disease.” Hum Mol Genet 10, no. 17 (August 15, 2001): 1847–51. https://doi.org/10.1093/hmg/10.17.1847.
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- Book Sections
  - West, A. B., M. Gray, and D. G. Standaert. “Basal Ganglia Disorders.” In Emery and Rimoin’s Principles and Practice of Medical Genetics, 1–39, 2013. https://doi.org/10.1016/B978-0-12-383834-6.00123-3.
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  - West, A. B., V. L. Dawson, and T. M. Dawson. “The role of PARKIN in parkinson’s disease.” In Parkinson’s Disease: Genetics and Pathogenesis, 199–218, 2007.
- Conference Papers
  - Abdelmotilib, Hisham, Andrew West, Laura Volpicelli-Daly, and Ashley Harms. “Interplay Between LRRK2 Action in Neurons and Macrophages in Mediating alpha-Synuclein linked Neurodegeneration.” In Neurology, Vol. 88, 2017.
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  - Zhao, Hien T., Karli Lee, Tracy Cole, Andreas Weihofen, Eric E. Swayze, Laura Volpicelli-Daley, Andrew B. West, and Holly B. Kordasiewicz. “Antisense Oligonucleotides to LRRK2 Ameliorate alpha-Synuclein Pathology and Behavioral Deficit Induced by Pre-Formed alpha-Synuclein Fibrils.” In Annals of Neurology, 82:S56–57, 2017.
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  - Daher, J. P. L., A. West, and W. Hirst. “Pharmacological inhibition of LRRK2 blocks alpha-synuclein induced neurodegeneration in rats.” In Journal of Neurochemistry, 134:280–81. WILEY-BLACKWELL, 2015.
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  - Alcalay, R. N., K. B. Fraser, and A. West. “Phosphorylated pS1292 LRRK2 to total LRRK2 concentration ratio in urine exosomes distinguishes LRRK2-PD and idiopathic PD.” In Movement Disorders, 30:S449–S449, 2015.
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  - Lockhart, P. J., A. B. West, C. A. O’Farrell, and M. J. Farrer. “Identification of a novel gene linked to Parkin via a bidirectional promoter.” In Annals of the New York Academy of Sciences, 991:311–14, 2003. https://doi.org/10.1111/j.1749-6632.2003.tb07493.x.
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