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Andrew Bradley West

Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
MSRB III 5124, DUMC 103853, Durham, NC 27710
3 Genome Court, MSRB III 5th FL, Durham, NC 27710

Research Interests


The West lab focuses on identifying critical pathogenic mechanisms underlying neurological diseases like Parkinson’s disease with the goal of developing new therapeutics to block disease progression. The West lab is housed in the brand-new Duke Center for Neurodegeneration and Neurotherapeutics and works with clinicians in the discovery of biomarkers for disease progression and therapeutic responses together with basic neuroscientists in defining pathways in neurons and immune cells that drive disease. 

Selected Grants


Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Pharmacologically targeting LRRK2 for the amelioration of tau aggregation and neurotoxicity

ResearchPrincipal Investigator · Awarded by Edward N. & Della L. Thome Memorial Foundation · 2024 - 2026

Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Pharmacologically targeting LRRK2 for the amelioration of tau aggregation and neurotoxicity

ResearchPrincipal Investigator · Awarded by Edward N. & Della L. Thome Memorial Foundation · 2024 - 2026

Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Role of enteroendocrine cells in the origin of Parkinson's pathology

ResearchCo Investigator · Awarded by Michael J. Fox Foundation for Parkinson's Research · 2021 - 2024

Innate and Adaptive Immunity in Parkinson Disease; Project 3: PD-linked Genetic Susceptibilities in Macrophage Responses

ResearchPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2018 - 2024

Neurobiology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2024

Urate-LLRK2 interactions in Parkinson's disease

ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2019 - 2024

Role of Rab10 in Alzheimer's disease

ResearchMentor · Awarded by National Institutes of Health · 2022 - 2024

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Characterization and functional analysis of PPMI LRRK2 variants

ResearchPrincipal Investigator · Awarded by Michael J. Fox Foundation for Parkinson's Research · 2018 - 2021

Efficacies and Pharmacodynamic Assays for LRRk2 Small-Molecule Inhibitors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2020

Exosome LRRK2 in Predicting Parkinson Disease Phenotypes

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2019

External Relationships


  • Michael J. Fox Foundation for Parkinson's Research

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.