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M1 and M2 immune activation in Parkinson's Disease: Foe and ally?

Publication ,  Journal Article
Moehle, MS; West, AB
Published in: Neuroscience
August 27, 2015

Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disorder of unknown etiology. Autopsy findings, genetics, retrospective studies, and molecular imaging all suggest a role for inflammation in the neurodegenerative process. However, relatively little is understood about the causes and implications of neuroinflammation in PD. Understanding how inflammation arises in PD, in particular the activation state of cells of the innate immune system, may provide an exciting opportunity for novel neuroprotective therapeutics. We analyze the evidence of immune system involvement in PD susceptibility, specifically in the context of M1 and M2 activation states. Tracking and modulating these activation states may provide new insights into both PD etiology and therapeutic strategies.

Duke Scholars

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Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

August 27, 2015

Volume

302

Start / End Page

59 / 73

Location

United States

Related Subject Headings

  • Parkinson Disease
  • Neurology & Neurosurgery
  • Microglia
  • Macrophages
  • Inflammation
  • Immune System
  • Humans
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Moehle, M. S., & West, A. B. (2015). M1 and M2 immune activation in Parkinson's Disease: Foe and ally? Neuroscience, 302, 59–73. https://doi.org/10.1016/j.neuroscience.2014.11.018
Moehle, M. S., and A. B. West. “M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Neuroscience 302 (August 27, 2015): 59–73. https://doi.org/10.1016/j.neuroscience.2014.11.018.
Moehle MS, West AB. M1 and M2 immune activation in Parkinson's Disease: Foe and ally? Neuroscience. 2015 Aug 27;302:59–73.
Moehle, M. S., and A. B. West. “M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Neuroscience, vol. 302, Aug. 2015, pp. 59–73. Pubmed, doi:10.1016/j.neuroscience.2014.11.018.
Moehle MS, West AB. M1 and M2 immune activation in Parkinson's Disease: Foe and ally? Neuroscience. 2015 Aug 27;302:59–73.
Journal cover image

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

August 27, 2015

Volume

302

Start / End Page

59 / 73

Location

United States

Related Subject Headings

  • Parkinson Disease
  • Neurology & Neurosurgery
  • Microglia
  • Macrophages
  • Inflammation
  • Immune System
  • Humans
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences