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Single-center analysis of infectious complications in older adults during the first year after kidney transplantation.

Publication ,  Journal Article
Hemmersbach-Miller, M; Alexander, BD; Sudan, DL; Pieper, C; Schmader, KE
Published in: Eur J Clin Microbiol Infect Dis
January 2019

Infections are among the top three causes of death of older adults in the first year after kidney transplantation (KT). Our aim was to describe infectious complications among KT recipients aged ≥ 65 during the first 12 months post-transplant. Single-center retrospective cohort study. Ninety-one KTs had been performed in patients ≥ 65 years of age between 2011 and 2015. 92.3% of the patients developed at least one infection. Infectious episodes increased the risk of future infection by 10% (p = 0.0018) with each infection portending a greater risk. At a patient level, viral (71.4%) and bacterial (70.2%) infections predominated. Urinary tract infections were the most frequent complication (30.3%), followed by cytomegalovirus infections (22.7%). Infections were the main reason for readmission. 7.7% of the patients developed rejection; and overall 3.3% lost their graft. Mortality at 1 year was 9.9%. Older KT recipients have a high incidence of infectious complications the first year after KT. Infections were the number one reason for readmission, and an infection episode predicted future infections for the individual patient. Despite these complications, the majority of older KT recipients were alive with a functioning graft at 1 year.

Duke Scholars

Published In

Eur J Clin Microbiol Infect Dis

DOI

EISSN

1435-4373

Publication Date

January 2019

Volume

38

Issue

1

Start / End Page

141 / 148

Location

Germany

Related Subject Headings

  • Urinary Tract Infections
  • Retrospective Studies
  • Middle Aged
  • Microbiology
  • Male
  • Kidney Transplantation
  • Incidence
  • Humans
  • Graft Rejection
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hemmersbach-Miller, M., Alexander, B. D., Sudan, D. L., Pieper, C., & Schmader, K. E. (2019). Single-center analysis of infectious complications in older adults during the first year after kidney transplantation. Eur J Clin Microbiol Infect Dis, 38(1), 141–148. https://doi.org/10.1007/s10096-018-3405-5
Hemmersbach-Miller, Marion, Barbara D. Alexander, Debra L. Sudan, Carl Pieper, and Kenneth E. Schmader. “Single-center analysis of infectious complications in older adults during the first year after kidney transplantation.Eur J Clin Microbiol Infect Dis 38, no. 1 (January 2019): 141–48. https://doi.org/10.1007/s10096-018-3405-5.
Hemmersbach-Miller M, Alexander BD, Sudan DL, Pieper C, Schmader KE. Single-center analysis of infectious complications in older adults during the first year after kidney transplantation. Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):141–8.
Hemmersbach-Miller, Marion, et al. “Single-center analysis of infectious complications in older adults during the first year after kidney transplantation.Eur J Clin Microbiol Infect Dis, vol. 38, no. 1, Jan. 2019, pp. 141–48. Pubmed, doi:10.1007/s10096-018-3405-5.
Hemmersbach-Miller M, Alexander BD, Sudan DL, Pieper C, Schmader KE. Single-center analysis of infectious complications in older adults during the first year after kidney transplantation. Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):141–148.
Journal cover image

Published In

Eur J Clin Microbiol Infect Dis

DOI

EISSN

1435-4373

Publication Date

January 2019

Volume

38

Issue

1

Start / End Page

141 / 148

Location

Germany

Related Subject Headings

  • Urinary Tract Infections
  • Retrospective Studies
  • Middle Aged
  • Microbiology
  • Male
  • Kidney Transplantation
  • Incidence
  • Humans
  • Graft Rejection
  • Female