Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Published

Journal Article

Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.

Full Text

Duke Authors

Cited Authors

  • Paust, S; Gill, HS; Wang, B-Z; Flynn, MP; Moseman, EA; Senman, B; Szczepanik, M; Telenti, A; Askenase, PW; Compans, RW; von Andrian, UH

Published Date

  • December 2010

Published In

Volume / Issue

  • 11 / 12

Start / End Page

  • 1127 - 1135

PubMed ID

  • 20972432

Pubmed Central ID

  • 20972432

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni.1953

Language

  • eng