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Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Publication ,  Journal Article
Paust, S; Gill, HS; Wang, B-Z; Flynn, MP; Moseman, EA; Senman, B; Szczepanik, M; Telenti, A; Askenase, PW; Compans, RW; von Andrian, UH
Published in: Nat Immunol
December 2010

Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.

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Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

December 2010

Volume

11

Issue

12

Start / End Page

1127 / 1135

Location

United States

Related Subject Headings

  • Viruses
  • Virus Diseases
  • Receptors, CXCR6
  • Receptors, CXCR
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Subsets
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
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Paust, S., Gill, H. S., Wang, B.-Z., Flynn, M. P., Moseman, E. A., Senman, B., … von Andrian, U. H. (2010). Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol, 11(12), 1127–1135. https://doi.org/10.1038/ni.1953
Paust, Silke, Harvinder S. Gill, Bao-Zhong Wang, Michael P. Flynn, E Ashley Moseman, Balimkiz Senman, Marian Szczepanik, et al. “Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.Nat Immunol 11, no. 12 (December 2010): 1127–35. https://doi.org/10.1038/ni.1953.
Paust S, Gill HS, Wang B-Z, Flynn MP, Moseman EA, Senman B, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127–35.
Paust, Silke, et al. “Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.Nat Immunol, vol. 11, no. 12, Dec. 2010, pp. 1127–35. Pubmed, doi:10.1038/ni.1953.
Paust S, Gill HS, Wang B-Z, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127–1135.

Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

December 2010

Volume

11

Issue

12

Start / End Page

1127 / 1135

Location

United States

Related Subject Headings

  • Viruses
  • Virus Diseases
  • Receptors, CXCR6
  • Receptors, CXCR
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Subsets
  • Liver