Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus.

Journal Article (Journal Article)

Group A Streptococcus (GAS) is classified on the basis of the sequence of the gene encoding the M protein (emm) and the patterns into which emm types are grouped. We discovered a novel emm pattern in emm4 GAS, historically considered pattern E, arising from a fusion event between emm and the adjacent enn gene. We identified the emm-enn fusion event in 51 out of 52 emm4 GAS strains isolated by national surveillance in 2015. GAS isolates with an emm-enn fusion event completely replaced pattern E emm4 strains over a 4-year span in Houston (2013-2017). The novel emm-enn gene fusion and new emm pattern has potential vaccine implications.

Full Text

Duke Authors

Cited Authors

  • DebRoy, S; Li, X; Kalia, A; Galloway-Pena, J; Shah, BJ; Fowler, VG; Flores, AR; Shelburne, SA

Published Date

  • November 2018

Published In

Volume / Issue

  • 4 / 11

PubMed ID

  • 30412460

Pubmed Central ID

  • PMC6321872

Electronic International Standard Serial Number (EISSN)

  • 2057-5858

Digital Object Identifier (DOI)

  • 10.1099/mgen.0.000235


  • eng

Conference Location

  • England