Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus.
Publication
, Journal Article
DebRoy, S; Li, X; Kalia, A; Galloway-Pena, J; Shah, BJ; Fowler, VG; Flores, AR; Shelburne, SA
Published in: Microb Genom
November 2018
Group A Streptococcus (GAS) is classified on the basis of the sequence of the gene encoding the M protein (emm) and the patterns into which emm types are grouped. We discovered a novel emm pattern in emm4 GAS, historically considered pattern E, arising from a fusion event between emm and the adjacent enn gene. We identified the emm-enn fusion event in 51 out of 52 emm4 GAS strains isolated by national surveillance in 2015. GAS isolates with an emm-enn fusion event completely replaced pattern E emm4 strains over a 4-year span in Houston (2013-2017). The novel emm-enn gene fusion and new emm pattern has potential vaccine implications.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Microb Genom
DOI
EISSN
2057-5858
Publication Date
November 2018
Volume
4
Issue
11
Location
England
Related Subject Headings
- Streptococcus pyogenes
- Humans
- Gene Fusion
- Carrier Proteins
- Bacterial Proteins
- Bacterial Outer Membrane Proteins
- Antigens, Bacterial
- 3107 Microbiology
- 3105 Genetics
- 0605 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
DebRoy, S., Li, X., Kalia, A., Galloway-Pena, J., Shah, B. J., Fowler, V. G., … Shelburne, S. A. (2018). Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus. Microb Genom, 4(11). https://doi.org/10.1099/mgen.0.000235
DebRoy, Sruti, Xiqi Li, Awdhesh Kalia, Jessica Galloway-Pena, Brittany J. Shah, Vance G. Fowler, Anthony R. Flores, and Samuel A. Shelburne. “Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus.” Microb Genom 4, no. 11 (November 2018). https://doi.org/10.1099/mgen.0.000235.
DebRoy S, Li X, Kalia A, Galloway-Pena J, Shah BJ, Fowler VG, et al. Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus. Microb Genom. 2018 Nov;4(11).
DebRoy, Sruti, et al. “Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus.” Microb Genom, vol. 4, no. 11, Nov. 2018. Pubmed, doi:10.1099/mgen.0.000235.
DebRoy S, Li X, Kalia A, Galloway-Pena J, Shah BJ, Fowler VG, Flores AR, Shelburne SA. Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus. Microb Genom. 2018 Nov;4(11).
Published In
Microb Genom
DOI
EISSN
2057-5858
Publication Date
November 2018
Volume
4
Issue
11
Location
England
Related Subject Headings
- Streptococcus pyogenes
- Humans
- Gene Fusion
- Carrier Proteins
- Bacterial Proteins
- Bacterial Outer Membrane Proteins
- Antigens, Bacterial
- 3107 Microbiology
- 3105 Genetics
- 0605 Microbiology