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Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study.

Publication ,  Journal Article
Doherty, BT; Hoffman, K; Keil, AP; Engel, SM; Stapleton, HM; Goldman, BD; Olshan, AF; Daniels, JL
Published in: Environmental research
February 2019

Organophosphate esters (OPEs) are a class of chemicals commonly used as flame retardants and plasticizers. OPEs are applied to a wide variety of consumer products and have a propensity to leach from these products. Consequently, OPEs are ubiquitous contaminants in many human environments and human exposure is pervasive. Accumulating evidence suggests that OPEs are capable of interfering with childhood cognitive development through both neurologic- and endocrine-mediated mechanisms. However, observational evidence of cognitive effects is limited. We used data collected in the third phase of the Pregnancy, Infection, and Nutrition Study to investigate cognitive effects of prenatal exposure to OPEs. In a spot prenatal maternal urine sample, we measured the following OPE metabolites: diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl phosphate) (BDCIPP), isopropyl-phenyl phenyl phosphate (ip-PPP), and 1-hydroxyl-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP). We assessed children's language and multi-faceted and overall cognitive development between two and three years of age using the MacArthur-Bates Communicative Development Inventories (MB-CDI) and the Mullen Scales of Early Learning (MSEL). We used linear regression to estimate the change in children's scores on these developmental assessments per interquartile range (IQR) increase in log-transformed, specific-gravity-corrected prenatal OPE metabolite concentrations, adjusted for maternal age, education, income, race/ethnicity, BMI, and child's sex. A total of 149 children had both OPE metabolite measurements and MB-CDI scores, and 227 children had both OPE metabolite measurements and MSEL scores. We observed that higher concentrations of ip-PPP (ng/ml) were associated with lower scores on the MSEL Cognitive Composite Score (β = -2.61; 95% CI: -5.69, 0.46), and separately on two of the four MSEL Scales that comprise the Cognitive Composite, specifically the Fine Motor Scale (β = -3.08; 95% CI: -5.26, -0.91) and the Expressive Language Scale (β = -1.21; 95% CI: -2.91, 0.49). We similarly observed that prenatal ip-PPP concentrations were inversely associated with age-standardized scores on the MB-CDI Vocabulary assessment (β = -1.19; 95% CI: -2.53, 0.16). Other OPE metabolites were not strongly associated with performance on either assessment. Our results suggest that isopropylated triarylphosphate isomers, the presumed parent compounds of ip-PPP, may adversely impact cognitive development, including fine motor skills and early language abilities. Our study contributes to the growing body of observational evidence that suggests prenatal exposure to OPEs may adversely affect cognitive development.

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Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

February 2019

Volume

169

Start / End Page

33 / 40

Related Subject Headings

  • Toxicology
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Organophosphates
  • Male
  • Infections
  • Humans
  • Flame Retardants
  • Female
  • Esters
 

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Doherty, B. T., Hoffman, K., Keil, A. P., Engel, S. M., Stapleton, H. M., Goldman, B. D., … Daniels, J. L. (2019). Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environmental Research, 169, 33–40. https://doi.org/10.1016/j.envres.2018.10.033
Doherty, Brett T., Kate Hoffman, Alexander P. Keil, Stephanie M. Engel, Heather M. Stapleton, Barbara D. Goldman, Andrew F. Olshan, and Julie L. Daniels. “Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study.Environmental Research 169 (February 2019): 33–40. https://doi.org/10.1016/j.envres.2018.10.033.
Doherty BT, Hoffman K, Keil AP, Engel SM, Stapleton HM, Goldman BD, et al. Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environmental research. 2019 Feb;169:33–40.
Doherty, Brett T., et al. “Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study.Environmental Research, vol. 169, Feb. 2019, pp. 33–40. Epmc, doi:10.1016/j.envres.2018.10.033.
Doherty BT, Hoffman K, Keil AP, Engel SM, Stapleton HM, Goldman BD, Olshan AF, Daniels JL. Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environmental research. 2019 Feb;169:33–40.
Journal cover image

Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

February 2019

Volume

169

Start / End Page

33 / 40

Related Subject Headings

  • Toxicology
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Organophosphates
  • Male
  • Infections
  • Humans
  • Flame Retardants
  • Female
  • Esters