Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review.

Published

Journal Article (Review)

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of HF, affecting over 3 million adults in the United States alone. HFpEF is a heterogenous syndrome. One important phenotype may be related to comorbid conditions, including diabetes mellitus (DM). DM has a prevalence of approximately 45% in HFpEF, but characteristics and outcomes of this population are poorly understood. In this review, the authors summarize data from several clinical trials of HFpEF therapeutics and provide original data from a large cohort using the Get With The Guidelines-HF registry, which together suggest that DM is associated with increased morbidity and long-term mortality in HFpEF. The authors then discuss several common pathological mechanisms in HFpEF and DM, including sodium retention, metabolic derangements, impaired skeletal muscle function, and potential therapeutic targets. As the understanding of comorbid HFpEF and DM improves, it is hoped clinicians will be better equipped to offer effective, patient-centered treatments.

Full Text

Duke Authors

Cited Authors

  • McHugh, K; DeVore, AD; Wu, J; Matsouaka, RA; Fonarow, GC; Heidenreich, PA; Yancy, CW; Green, JB; Altman, N; Hernandez, AF

Published Date

  • February 2019

Published In

Volume / Issue

  • 73 / 5

Start / End Page

  • 602 - 611

PubMed ID

  • 30732715

Pubmed Central ID

  • 30732715

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

International Standard Serial Number (ISSN)

  • 0735-1097

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2018.11.033

Language

  • eng