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Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review.

Publication ,  Journal Article
McHugh, K; DeVore, AD; Wu, J; Matsouaka, RA; Fonarow, GC; Heidenreich, PA; Yancy, CW; Green, JB; Altman, N; Hernandez, AF
Published in: Journal of the American College of Cardiology
February 2019

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of HF, affecting over 3 million adults in the United States alone. HFpEF is a heterogenous syndrome. One important phenotype may be related to comorbid conditions, including diabetes mellitus (DM). DM has a prevalence of approximately 45% in HFpEF, but characteristics and outcomes of this population are poorly understood. In this review, the authors summarize data from several clinical trials of HFpEF therapeutics and provide original data from a large cohort using the Get With The Guidelines-HF registry, which together suggest that DM is associated with increased morbidity and long-term mortality in HFpEF. The authors then discuss several common pathological mechanisms in HFpEF and DM, including sodium retention, metabolic derangements, impaired skeletal muscle function, and potential therapeutic targets. As the understanding of comorbid HFpEF and DM improves, it is hoped clinicians will be better equipped to offer effective, patient-centered treatments.

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Published In

Journal of the American College of Cardiology

DOI

EISSN

1558-3597

ISSN

0735-1097

Publication Date

February 2019

Volume

73

Issue

5

Start / End Page

602 / 611

Related Subject Headings

  • Stroke Volume
  • Humans
  • Heart Failure
  • Disease Management
  • Diabetes Mellitus
  • Comorbidity
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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McHugh, K., DeVore, A. D., Wu, J., Matsouaka, R. A., Fonarow, G. C., Heidenreich, P. A., … Hernandez, A. F. (2019). Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 73(5), 602–611. https://doi.org/10.1016/j.jacc.2018.11.033
McHugh, Kelly, Adam D. DeVore, Jingjing Wu, Roland A. Matsouaka, Gregg C. Fonarow, Paul A. Heidenreich, Clyde W. Yancy, Jennifer B. Green, Natasha Altman, and Adrian F. Hernandez. “Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review.Journal of the American College of Cardiology 73, no. 5 (February 2019): 602–11. https://doi.org/10.1016/j.jacc.2018.11.033.
McHugh K, DeVore AD, Wu J, Matsouaka RA, Fonarow GC, Heidenreich PA, et al. Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2019 Feb;73(5):602–11.
McHugh, Kelly, et al. “Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review.Journal of the American College of Cardiology, vol. 73, no. 5, Feb. 2019, pp. 602–11. Epmc, doi:10.1016/j.jacc.2018.11.033.
McHugh K, DeVore AD, Wu J, Matsouaka RA, Fonarow GC, Heidenreich PA, Yancy CW, Green JB, Altman N, Hernandez AF. Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2019 Feb;73(5):602–611.
Journal cover image

Published In

Journal of the American College of Cardiology

DOI

EISSN

1558-3597

ISSN

0735-1097

Publication Date

February 2019

Volume

73

Issue

5

Start / End Page

602 / 611

Related Subject Headings

  • Stroke Volume
  • Humans
  • Heart Failure
  • Disease Management
  • Diabetes Mellitus
  • Comorbidity
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology