Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.

Published online

Journal Article

BACKGROUND: Chronic low back pain (cLBP) affects millions of Americans and costs billions. Studies suggest a link between cLBP and joint hypermobility. METHODS: We conducted cross-sectional primary analyses of joint hypermobility and cLBP, lumbar spine osteoarthritis (OA), and lumbar facet joint OA (FOA) in 3 large studies-the Generalized Osteoarthritis Study, Genetics of Generalized Osteoarthritis Study, and Johnston County Osteoarthritis Project (total n = 5072). Associations of joint hypermobility and Beighton trunk flexion with cLBP and lumbar OA were estimated using separate adjusted logistic regression models. Adjusted pooled odds ratios (pORs) and 95% confidence intervals (CIs) were then summarized-using random effect univariate, multivariate crude, and adjusted models-and heterogeneity was determined (I2 statistic). RESULTS: In univariate models, hypermobility was associated with symptomatic FOA (pOR = 0.64 [95% CI 0.44, 0.93]) but this result was not found in the multivariate models. In multivariate adjusted models, hypermobility was not significantly associated with cLBP and lumbar OA, but trunk flexion was inversely associated with cLBP (pOR = 0.40 [95% 0.26, 0.62]), spine OA (pOR = 0.66 [95% CI 0.50, 0.87]), symptomatic spine OA (pOR = 0.39 [95% CI 0.28, 0.53]), and symptomatic FOA (pOR = 0.53 [95% CI 0.37, 0.77]). Generally, between-study heterogeneity was moderate-high. CONCLUSIONS: Hypermobility was not associated with cLBP or lumbar OA. The inverse association of trunk flexion with cLBP and lumbar OA may indicate a role for a flexible spine in avoiding or managing these conditions.

Full Text

Duke Authors

Cited Authors

  • Goode, AP; Cleveland, RJ; Schwartz, TA; Nelson, AE; Kraus, VB; Hillstrom, HJ; Hannan, MT; Flowers, P; Renner, JB; Jordan, JM; Golightly, YM

Published Date

  • April 9, 2019

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 158 -

PubMed ID

  • 30967130

Pubmed Central ID

  • 30967130

Electronic International Standard Serial Number (EISSN)

  • 1471-2474

Digital Object Identifier (DOI)

  • 10.1186/s12891-019-2523-2


  • eng

Conference Location

  • England