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Dusting off the numbers of in situ particle analysis: a 35-year experience.

Publication ,  Journal Article
Carney, JM; Pavlisko, EN; Sporn, TA; Roggli, VL
Published in: Ultrastruct Pathol
2019

A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in morphology between diseases caused by dust inhalation (mineral pneumoconiosis) and other lung diseases. In such cases, analytical scanning electron microscopy (SEM) can provide valuable information to assist the pathologist in making the correct diagnosis. We report herein our findings in 96 cases in which in situ particle analysis (ISPA) was performed with the SEM. This included 56 cases of pneumoconiosis as well as 40 cases of other types of interstitial lung disease. The most common diagnosis for which ISPA was performed in individuals with pneumoconiosis was mixed dust pneumoconiosis (14 cases). The most common diagnoses for which ISPA was performed in individuals with other diseases were sarcoidosis (13 cases) and hypersensitivity pneumonitis (10 cases). In addition to a detailed description of our methodology, we also report other circumstances in which ISPA assists in the diagnosis of pulmonary disease.

Duke Scholars

Published In

Ultrastruct Pathol

DOI

EISSN

1521-0758

Publication Date

2019

Volume

43

Issue

2-3

Start / End Page

110 / 116

Location

England

Related Subject Headings

  • Pneumoconiosis
  • Pathology
  • Occupational Exposure
  • Microscopy, Electron, Scanning
  • Lung
  • Humans
  • Data Analysis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carney, J. M., Pavlisko, E. N., Sporn, T. A., & Roggli, V. L. (2019). Dusting off the numbers of in situ particle analysis: a 35-year experience. Ultrastruct Pathol, 43(2–3), 110–116. https://doi.org/10.1080/01913123.2019.1619006
Carney, John M., Elizabeth N. Pavlisko, Thomas A. Sporn, and Victor L. Roggli. “Dusting off the numbers of in situ particle analysis: a 35-year experience.Ultrastruct Pathol 43, no. 2–3 (2019): 110–16. https://doi.org/10.1080/01913123.2019.1619006.
Carney JM, Pavlisko EN, Sporn TA, Roggli VL. Dusting off the numbers of in situ particle analysis: a 35-year experience. Ultrastruct Pathol. 2019;43(2–3):110–6.
Carney, John M., et al. “Dusting off the numbers of in situ particle analysis: a 35-year experience.Ultrastruct Pathol, vol. 43, no. 2–3, 2019, pp. 110–16. Pubmed, doi:10.1080/01913123.2019.1619006.
Carney JM, Pavlisko EN, Sporn TA, Roggli VL. Dusting off the numbers of in situ particle analysis: a 35-year experience. Ultrastruct Pathol. 2019;43(2–3):110–116.

Published In

Ultrastruct Pathol

DOI

EISSN

1521-0758

Publication Date

2019

Volume

43

Issue

2-3

Start / End Page

110 / 116

Location

England

Related Subject Headings

  • Pneumoconiosis
  • Pathology
  • Occupational Exposure
  • Microscopy, Electron, Scanning
  • Lung
  • Humans
  • Data Analysis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences