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The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.

Publication ,  Journal Article
Chen, M; Xu, ES; Leisenring, NH; Cardona, DM; Luo, L; Ma, Y; Ventura, A; Kirsch, DG
Published in: Sarcoma
2019

Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. Here, we report the generation and characterization of a spatially and temporally restricted mouse model of sarcoma driven by FUS-CHOP. Using different Cre drivers in the adipocyte lineage, we initiated in vivo tumorigenesis by expressing FUS-CHOP in Prrx1+ mesenchymal progenitor cells. In contrast, expression of FUS-CHOP in more differentiated cells does not form tumors in vivo, and early expression of the oncoprotein during embryogenesis is lethal. We also employ in vivo electroporation and CRISPR technology to rapidly generate spatially and temporally restricted mouse models of high-grade FUS-CHOP-driven sarcomas for preclinical studies.

Duke Scholars

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Published In

Sarcoma

DOI

ISSN

1357-714X

Publication Date

2019

Volume

2019

Start / End Page

1340261

Location

Egypt

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

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Chen, M., Xu, E. S., Leisenring, N. H., Cardona, D. M., Luo, L., Ma, Y., … Kirsch, D. G. (2019). The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Sarcoma, 2019, 1340261. https://doi.org/10.1155/2019/1340261
Chen, Mark, Eric S. Xu, Nathan H. Leisenring, Diana M. Cardona, Lixia Luo, Yan Ma, Andrea Ventura, and David G. Kirsch. “The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.Sarcoma 2019 (2019): 1340261. https://doi.org/10.1155/2019/1340261.
Chen M, Xu ES, Leisenring NH, Cardona DM, Luo L, Ma Y, et al. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Sarcoma. 2019;2019:1340261.
Chen, Mark, et al. “The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.Sarcoma, vol. 2019, 2019, p. 1340261. Pubmed, doi:10.1155/2019/1340261.
Chen M, Xu ES, Leisenring NH, Cardona DM, Luo L, Ma Y, Ventura A, Kirsch DG. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Sarcoma. 2019;2019:1340261.
Journal cover image

Published In

Sarcoma

DOI

ISSN

1357-714X

Publication Date

2019

Volume

2019

Start / End Page

1340261

Location

Egypt

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences