Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?

Journal Article (Journal Article)

Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndrome has gained recognition. The study by Colucci and colleagues provides preliminary evidence that production of deglycosylated IgM that is unable to regulate T-cell function in the presence or absence of corticosteroid may be responsible for a steroid-dependence course in SSNS. This study provides invaluable insights into the mechanistic roles of both T-cell and B-cell responses in the pathogenesis and clinical course of SSNS.

Full Text

Duke Authors

Cited Authors

  • Chambers, ET; Gbadegesin, RA

Published Date

  • October 2019

Published In

Volume / Issue

  • 96 / 4

Start / End Page

  • 818 - 820

PubMed ID

  • 31543150

Pubmed Central ID

  • PMC8049454

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2019.05.031


  • eng

Conference Location

  • United States