Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?
Journal Article (Journal Article)
Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndrome has gained recognition. The study by Colucci and colleagues provides preliminary evidence that production of deglycosylated IgM that is unable to regulate T-cell function in the presence or absence of corticosteroid may be responsible for a steroid-dependence course in SSNS. This study provides invaluable insights into the mechanistic roles of both T-cell and B-cell responses in the pathogenesis and clinical course of SSNS.
Full Text
Duke Authors
Cited Authors
- Chambers, ET; Gbadegesin, RA
Published Date
- October 2019
Published In
Volume / Issue
- 96 / 4
Start / End Page
- 818 - 820
PubMed ID
- 31543150
Pubmed Central ID
- PMC8049454
Electronic International Standard Serial Number (EISSN)
- 1523-1755
Digital Object Identifier (DOI)
- 10.1016/j.kint.2019.05.031
Language
- eng
Conference Location
- United States