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A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.

Publication ,  Journal Article
Zigler, CK; Ardalan, K; Lane, S; Schollaert, KL; Torok, KS
Published in: Br J Dermatol
March 2020

BACKGROUND: According to current standards, no existing patient-reported outcome (PRO) measures have high-quality validity evidence for use with individuals diagnosed with paediatric localized scleroderma (LS). This severely hinders patient-centred LS-focused research, including much needed clinical trials. OBJECTIVES: To develop a valid health-related quality of life measure for individuals with paediatric LS and to qualitatively evaluate its content validity using a patient-centred approach. METHODS: Previously collected qualitative data from youth with LS and their caregivers was used to develop items. The resulting item set was administered in a clinical setting to participants aged 8-18 years old. Cognitive interviews were used to evaluate time to survey completion, readability/understanding of the items, appropriateness of the recall period and construct representation. RESULTS: Seventeen children and adolescents with LS participated in the study. Interviews supported readability, understanding of the items and appropriateness of the recall period in individuals > 10 years old. Revisions were made to simplify the instructions and to be more inclusive of different subtypes of LS. Three items were added to improve content representation. CONCLUSIONS: Content validity was supported by the patient-centred development process of the outcome measure and via direct feedback from individuals with LS and their families. Although an important first step, the resulting PRO, termed the Localized Scleroderma Quality of Life Instrument, should be further evaluated in a larger sample before being implemented. What's already known about this topic? No current health-related quality of life (HRQoL) measures have been created using direct input from children and adolescents with localized scleroderma (LS). When compared with qualitative reports of HRQoL impact in youth with all LS subtypes, no existing patient-reported outcome (PRO) measures have appropriate content validity for individuals with paediatric LS. What does this study add? This study proposes a novel LS-specific PRO and is the first qualitative assessment of content validity for any PRO measure in this population. Results from cognitive interviews with children and adolescents support the content validity of the newly developed item set and its ability to capture HRQoL impact in a clinical context. What are the clinical implications of this work? Incorporating a content-valid PRO of HRQoL impact into clinical practice would allow for the valid, ongoing capture of patient experience in LS. Although content validity is an important and necessary step in the process of evaluating validity, items within this novel measure will undergo additional psychometric evaluation before implementation in research and clinical settings.

Duke Scholars

Published In

Br J Dermatol

DOI

EISSN

1365-2133

Publication Date

March 2020

Volume

182

Issue

3

Start / End Page

625 / 635

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Scleroderma, Localized
  • Reproducibility of Results
  • Quality of Life
  • Qualitative Research
  • Psychometrics
  • Patient Reported Outcome Measures
  • Humans
  • Dermatology & Venereal Diseases
  • Child
 

Citation

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Zigler, C. K., Ardalan, K., Lane, S., Schollaert, K. L., & Torok, K. S. (2020). A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity. Br J Dermatol, 182(3), 625–635. https://doi.org/10.1111/bjd.18512
Zigler, C. K., K. Ardalan, S. Lane, K. L. Schollaert, and K. S. Torok. “A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.Br J Dermatol 182, no. 3 (March 2020): 625–35. https://doi.org/10.1111/bjd.18512.
Zigler CK, Ardalan K, Lane S, Schollaert KL, Torok KS. A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity. Br J Dermatol. 2020 Mar;182(3):625–35.
Zigler, C. K., et al. “A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.Br J Dermatol, vol. 182, no. 3, Mar. 2020, pp. 625–35. Pubmed, doi:10.1111/bjd.18512.
Zigler CK, Ardalan K, Lane S, Schollaert KL, Torok KS. A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity. Br J Dermatol. 2020 Mar;182(3):625–635.
Journal cover image

Published In

Br J Dermatol

DOI

EISSN

1365-2133

Publication Date

March 2020

Volume

182

Issue

3

Start / End Page

625 / 635

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Scleroderma, Localized
  • Reproducibility of Results
  • Quality of Life
  • Qualitative Research
  • Psychometrics
  • Patient Reported Outcome Measures
  • Humans
  • Dermatology & Venereal Diseases
  • Child