In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.

Journal Article (Journal Article)

PURPOSE: In patients with idiopathic pulmonary fibrosis (IPF), hospitalizations are associated with high mortality. We sought to determine in-hospital mortality rates and factors associated with in-hospital mortality in patients with IPF. METHODS: Patients with IPF were identified from the Premier Healthcare Database, a representative administrative dataset that includes > 20% of hospital discharges in the US, using an algorithm based on diagnostic codes and billing data. We used logistic regression to analyze associations between patient-, hospital-, and treatment-related characteristics and a composite primary outcome of death during the index visit, lung transplant during the index visit and > 1 day after admission, or death during a readmission within 90 days. RESULTS: The cohort comprised 6665 patients with IPF hospitalized between October 2011 and October 2014. A total of 963 (14.4%) met the primary outcome. Factors significantly associated with a higher risk of the primary outcome included mechanical ventilation [odds ratio 4.65 (95% CI 3.73, 5.80)], admission to the intensive care unit [1.83 (1.52, 2.21)], treatment with opioids (3.06 [2.57, 3.65]), and a diagnosis of pneumonia [1.44 (1.21, 1.71)]. Factors significantly associated with a lower risk included concurrent chronic obstructive pulmonary disease [0.65 (0.55, 0.77)] and female sex [0.67 (0.57, 0.79)]. CONCLUSIONS: Patients with IPF, particularly those receiving mechanical ventilation or intensive care, are at substantial risk of death or lung transplant during hospitalization or death during a readmission within 90 days.

Full Text

Duke Authors

Cited Authors

  • Durheim, MT; Judy, J; Bender, S; Baumer, D; Lucas, J; Robinson, SB; Mohamedaly, O; Shah, BR; Leonard, T; Conoscenti, CS; Palmer, SM

Published Date

  • December 2019

Published In

Volume / Issue

  • 197 / 6

Start / End Page

  • 699 - 707

PubMed ID

  • 31541276

Pubmed Central ID

  • PMC6861436

Electronic International Standard Serial Number (EISSN)

  • 1432-1750

Digital Object Identifier (DOI)

  • 10.1007/s00408-019-00270-z


  • eng

Conference Location

  • United States