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In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.

Publication ,  Journal Article
Durheim, MT; Judy, J; Bender, S; Baumer, D; Lucas, J; Robinson, SB; Mohamedaly, O; Shah, BR; Leonard, T; Conoscenti, CS; Palmer, SM
Published in: Lung
December 2019

PURPOSE: In patients with idiopathic pulmonary fibrosis (IPF), hospitalizations are associated with high mortality. We sought to determine in-hospital mortality rates and factors associated with in-hospital mortality in patients with IPF. METHODS: Patients with IPF were identified from the Premier Healthcare Database, a representative administrative dataset that includes > 20% of hospital discharges in the US, using an algorithm based on diagnostic codes and billing data. We used logistic regression to analyze associations between patient-, hospital-, and treatment-related characteristics and a composite primary outcome of death during the index visit, lung transplant during the index visit and > 1 day after admission, or death during a readmission within 90 days. RESULTS: The cohort comprised 6665 patients with IPF hospitalized between October 2011 and October 2014. A total of 963 (14.4%) met the primary outcome. Factors significantly associated with a higher risk of the primary outcome included mechanical ventilation [odds ratio 4.65 (95% CI 3.73, 5.80)], admission to the intensive care unit [1.83 (1.52, 2.21)], treatment with opioids (3.06 [2.57, 3.65]), and a diagnosis of pneumonia [1.44 (1.21, 1.71)]. Factors significantly associated with a lower risk included concurrent chronic obstructive pulmonary disease [0.65 (0.55, 0.77)] and female sex [0.67 (0.57, 0.79)]. CONCLUSIONS: Patients with IPF, particularly those receiving mechanical ventilation or intensive care, are at substantial risk of death or lung transplant during hospitalization or death during a readmission within 90 days.

Duke Scholars

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Published In

Lung

DOI

EISSN

1432-1750

Publication Date

December 2019

Volume

197

Issue

6

Start / End Page

699 / 707

Location

United States

Related Subject Headings

  • United States
  • Sex Factors
  • Risk Factors
  • Respiratory System
  • Respiration, Artificial
  • Pulmonary Disease, Chronic Obstructive
  • Protective Factors
  • Pneumonia
  • Patient Readmission
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Durheim, M. T., Judy, J., Bender, S., Baumer, D., Lucas, J., Robinson, S. B., … Palmer, S. M. (2019). In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study. Lung, 197(6), 699–707. https://doi.org/10.1007/s00408-019-00270-z
Durheim, Michael T., Jennifer Judy, Shaun Bender, Dorothy Baumer, Joseph Lucas, Scott B. Robinson, Omar Mohamedaly, et al. “In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.Lung 197, no. 6 (December 2019): 699–707. https://doi.org/10.1007/s00408-019-00270-z.
Durheim MT, Judy J, Bender S, Baumer D, Lucas J, Robinson SB, et al. In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study. Lung. 2019 Dec;197(6):699–707.
Durheim, Michael T., et al. “In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.Lung, vol. 197, no. 6, Dec. 2019, pp. 699–707. Pubmed, doi:10.1007/s00408-019-00270-z.
Durheim MT, Judy J, Bender S, Baumer D, Lucas J, Robinson SB, Mohamedaly O, Shah BR, Leonard T, Conoscenti CS, Palmer SM. In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study. Lung. 2019 Dec;197(6):699–707.
Journal cover image

Published In

Lung

DOI

EISSN

1432-1750

Publication Date

December 2019

Volume

197

Issue

6

Start / End Page

699 / 707

Location

United States

Related Subject Headings

  • United States
  • Sex Factors
  • Risk Factors
  • Respiratory System
  • Respiration, Artificial
  • Pulmonary Disease, Chronic Obstructive
  • Protective Factors
  • Pneumonia
  • Patient Readmission
  • Middle Aged