What are the respiratory effects of e-cigarettes?

Journal Article (Journal Article;Review)

Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to current smokers, former smokers, and young people who have never smoked. E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices. Their effectiveness as a smoking cessation intervention, their impact at a population level, and whether they are less harmful than combustible tobacco products are highly controversial. Here, we review the evidence on the effects of e-cigarettes on respiratory health. Studies show measurable adverse biologic effects on organ and cellular health in humans, in animals, and in vitro. The effects of e-cigarettes have similarities to and important differences from those of cigarettes. Decades of chronic smoking are needed for development of lung diseases such as lung cancer or chronic obstructive pulmonary disease, so the population effects of e-cigarette use may not be apparent until the middle of this century. We conclude that current knowledge of these effects is insufficient to determine whether the respiratory health effects of e-cigarette are less than those of combustible tobacco products.

Full Text

Duke Authors

Cited Authors

  • Gotts, JE; Jordt, S-E; McConnell, R; Tarran, R

Published Date

  • September 30, 2019

Published In

Volume / Issue

  • 366 /

Start / End Page

  • l5275 -

PubMed ID

  • 31570493

Pubmed Central ID

  • PMC7850161

Electronic International Standard Serial Number (EISSN)

  • 1756-1833

Digital Object Identifier (DOI)

  • 10.1136/bmj.l5275


  • eng

Conference Location

  • England