Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy.

Journal Article (Journal Article;Review)

Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms. We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis. Finally, we consider various approaches of therapeutically modulating these longevity pathways, highlighting exercise as a potent geroprotector.

Full Text

Duke Authors

Cited Authors

  • Bareja, A; Lee, DE; White, JP

Published Date

  • 2019

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 183 -

PubMed ID

  • 31555646

Pubmed Central ID

  • PMC6742954

International Standard Serial Number (ISSN)

  • 2296-634X

Digital Object Identifier (DOI)

  • 10.3389/fcell.2019.00183

Language

  • eng

Conference Location

  • Switzerland