Scholars@Duke

• Background
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  Education, Training, & Certifications

  • D.Phil., University of Oxford (United Kingdom) 2011
• Expertise
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  Subject Headings

  • Data Science
  • Machine learning
  • R (Computer program language)
  • Stem Cells
• Research
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  Selected Grants

  • Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease awarded by National Institutes of Health 2019 - 2024
  • Correction of Immune Response Improves Aged Fracture Healing awarded by National Institutes of Health 2020 - 2023
  • Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
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  Fellowships, Supported Research, & Other Grants

  • Seed Grant: Computational Biology Reading Group (CBRG) awarded by Duke Office for Faculty Advancement 2022
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.
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    • Orenduff, Melissa C., Michael F. Coleman, Elaine M. Glenny, Kim M. Huffman, Erika T. Rezeli, Akshay Bareja, Carl F. Pieper, Virginia B. Kraus, and Stephen D. Hursting. “Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.” Exp Gerontol 165 (August 2022): 111841. https://doi.org/10.1016/j.exger.2022.111841.
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    • Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.
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    • Huffman, Kim M., Brian J. Andonian, Dennis M. Abraham, Akshay Bareja, David E. Lee, Lauren H. Katz, Janet L. Huebner, William E. Kraus, and James P. White. “Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.” J Appl Physiol (1985) 130, no. 3 (March 1, 2021): 853–64. https://doi.org/10.1152/japplphysiol.00576.2020.
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    • Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.
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    • Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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    • Lee, David E., Akshay Bareja, David B. Bartlett, and James P. White. “Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration.” Cells 8, no. 2 (February 20, 2019). https://doi.org/10.3390/cells8020183.
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    • Bareja, Akshay, David E. Lee, and James P. White. “Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy.” Front Cell Dev Biol 7 (2019): 183. https://doi.org/10.3389/fcell.2019.00183.
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    • Bareja, Akshay, Shubham Patel, Conrad P. Hodgkinson, Alan Payne, and Victor J. Dzau. “Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.” Cell Signal 46 (June 2018): 113–19. https://doi.org/10.1016/j.cellsig.2018.02.013.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Erik Soderblom, Greg Waitt, and Victor J. Dzau. “The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.” J Biol Chem 293, no. 17 (April 27, 2018): 6449–59. https://doi.org/10.1074/jbc.RA118.002406.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Alan J. Payne, Richard E. Pratt, and Victor J. Dzau. “HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.” Biochem J 474, no. 5 (February 20, 2017): 771–80. https://doi.org/10.1042/BCJ20160976.
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    • Hodgkinson, Conrad P., Akshay Bareja, José A. Gomez, and Victor J. Dzau. “Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.” Circ Res 118, no. 1 (January 8, 2016): 95–107. https://doi.org/10.1161/CIRCRESAHA.115.305373.
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    • Bareja, Akshay, Jason A. Holt, Guizhen Luo, Calvin Chang, Junyu Lin, Aaron C. Hinken, Johannes M. Freudenberg, William E. Kraus, William J. Evans, and Andrew N. Billin. “Human and mouse skeletal muscle stem cells: convergent and divergent mechanisms of myogenesis.” Plos One 9, no. 2 (2014): e90398. https://doi.org/10.1371/journal.pone.0090398.
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    • Bareja, Akshay, and Andrew N. Billin. “Satellite cell therapy - from mice to men.” Skelet Muscle 3, no. 1 (January 31, 2013): 2. https://doi.org/10.1186/2044-5040-3-2.
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    • Fairclough, Rebecca J., Akshay Bareja, and Kay E. Davies. “Progress in therapy for Duchenne muscular dystrophy.” Exp Physiol 96, no. 11 (November 2011): 1101–13. https://doi.org/10.1113/expphysiol.2010.053025.
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    • Li, Dejia, Akshay Bareja, Luke Judge, Yongping Yue, Yi Lai, Rebecca Fairclough, Kay E. Davies, Jeffrey S. Chamberlain, and Dongsheng Duan. “Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.” J Cell Sci 123, no. Pt 12 (June 15, 2010): 2008–13. https://doi.org/10.1242/jcs.064808.
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  • Book Sections

    • Hodgkinson, C. P., J. A. Gomez, A. Bareja, and V. J. Dzau. “Role of Paracrine Mechanisms.” In Stem Cell and Gene Therapy for Cardiovascular Disease, 39–48, 2015. https://doi.org/10.1016/B978-0-12-801888-0.00004-7.
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  • Conference Papers

    • Bareja, Akshay, Conrad Hodgkinson, Alan Payne, Richard Pratt, and Victor Dzau. “Hypoxia and Akt Induced Stem Cell Factor Exerts Cardioprotective Effects via Specific Binding to the Insulin-Like Growth Factor-1 Receptor.” In Circulation, Vol. 130, 2014.
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    • Fairclough, R. J., D. Powell, S. Squire, A. Potter, A. Bareja, A. J. Russell, S. G. Davies, and K. E. Davies. “P05 Utrophin upregulation in DMD therapy: current status and new tools for the future.” In Neuromuscular Disorders, 21:S8–S8. Elsevier BV, 2011. https://doi.org/10.1016/s0960-8966(11)70024-4.
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    • Bareja, A., R. J. Fairclough, A. Potter, D. Powell, S. Squire, and K. E. Davies. “P23 Assessing the effects of exercise-induced stress on the Fiona mouse model.” In Neuromuscular Disorders, 20:S11–S11. Elsevier BV, 2010. https://doi.org/10.1016/s0960-8966(10)70038-9.
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    • Fairclough, R. J., A. Potter, D. Powell, S. Squire, M. Bland, A. Bareja, J. Tinsley, and K. E. Davies. “T.P.4.02 Evaluation of novel compounds for upregulation of utrophin in animal models of Duchenne muscular dystrophy therapy.” In Neuromuscular Disorders, 18:812–812. Elsevier BV, 2008. https://doi.org/10.1016/j.nmd.2008.06.302.
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• Teaching & Mentoring
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  Recent Courses

  • SCISOC 256: Science and Society 2023

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