Scholars@Duke
Akshay Bareja

Selected Publications

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.

Journal Article Cell Rep · March 26, 2024 An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274 ... Full text Link to item Cite

Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.

Journal Article Clin Chem · March 2, 2024 BACKGROUND: Lipid profiling is central for coronary artery disease (CAD) risk assessment. Nonadherence or unreported use of lipid-lowering drugs, particularly statins, can significantly complicate the association between lipid profile measures and CAD clin ... Full text Link to item Cite

Multi-omic rejuvenation and life span extension on exposure to youthful circulation

Journal Article Nature Aging · August 1, 2023 Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues. However, its impact on biological age and long-term health is unknown. Here we performed extended (3-month) HPB, followed by a 2-month detachment ... Full text Cite

Editorial: Manual on how to make and use an organoid: current and future directions

Journal Article Frontiers in Endocrinology · January 1, 2023 Full text Cite

Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.

Journal Article Nat Commun · December 9, 2022 Pathologies associated with sarcopenia include decline in muscular strength, lean mass and regenerative capacity. Despite the substantial impact on quality of life, no pharmacological therapeutics are available to counteract the age-associated decline in f ... Full text Link to item Cite

Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

Journal Article Exp Gerontol · August 2022 Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, ... Full text Link to item Cite

Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.

Journal Article Mech Ageing Dev · April 2021 Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR ... Full text Link to item Cite

Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.

Journal Article J Appl Physiol (1985) · March 1, 2021 Rheumatoid arthritis (RA) is a systemic inflammatory arthritis impacting primarily joints and cardiac and skeletal muscle. RA's distinct impact on cardiac and skeletal muscle tissue is suggested by studies showing that new RA pharmacologic agents strongly ... Full text Link to item Cite

Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Journal Article Nature metabolism · August 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Cite

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Journal Article Nat Metab · March 2020 The immune system plays a multifunctional role throughout the regenerative process, regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present study, we identify the myokine/cytokine Meteorin-like (Metrnl) as a critical regu ... Full text Link to item Cite

Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration.

Journal Article Cells · February 20, 2019 Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of s ... Full text Link to item Cite

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy.

Journal Article Front Cell Dev Biol · 2019 Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range ... Full text Link to item Cite

Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.

Journal Article Cell Signal · June 2018 The development of biased agonist drugs is widely recognized to be important for the treatment of many diseases, including cardiovascular disease. While GPCR biased agonism has been heavily characterized there is a distinct lack of information with respect ... Full text Link to item Cite

The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.

Journal Article J Biol Chem · April 27, 2018 The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously ... Full text Link to item Cite

HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.

Journal Article Biochem J · February 20, 2017 We have recently shown that hypoxia and Akt-induced stem cell factor (HASF) protects the heart from ischemia-induced damage and promotes cardiomyocyte proliferation. While we have identified certain signaling pathways responsible for these protective effec ... Full text Link to item Cite

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.

Journal Article Circ Res · January 8, 2016 In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data su ... Full text Link to item Cite

Role of Paracrine Mechanisms

Chapter · January 1, 2015 Many studies have demonstrated that the exogenous delivery of stem cells into injured myocardium results in functional improvements. It was originally thought that the regenerative properties of these stem cells arose from engraftment into the myocardium a ... Full text Cite

Human and mouse skeletal muscle stem cells: convergent and divergent mechanisms of myogenesis.

Journal Article PLoS One · 2014 Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study of mouse satellite cells has accelerated in recent years due to technical advancements in the isolation of these cells. The study of human satellite cells has l ... Full text Link to item Cite

Satellite cell therapy - from mice to men.

Journal Article Skelet Muscle · January 31, 2013 Satellite cells are rare mononuclear skeletal muscle-resident cells that are the chief contributors to regenerative myogenesis following muscle injury. Although first identified more than 50 years ago, it is only recently that the murine satellite cell has ... Full text Link to item Cite

Progress in therapy for Duchenne muscular dystrophy.

Journal Article Exp Physiol · November 2011 Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations in the dystrophin gene destroy the link between the internal muscle filaments and the extracellular matrix, resulting in severe muscle weakness and progressive muscle w ... Full text Link to item Cite

Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.

Journal Article J Cell Sci · June 15, 2010 Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to an ... Full text Link to item Cite