Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.
Publication
, Journal Article
Bareja, A; Draper, JA; Katz, LH; Lee, DE; Grimsrud, PA; White, JP
Published in: Mech Ageing Dev
April 2021
Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.
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Published In
Mech Ageing Dev
DOI
EISSN
1872-6216
Publication Date
April 2021
Volume
195
Start / End Page
111443
Location
Ireland
Related Subject Headings
- Time
- Signal Transduction
- Rejuvenation
- Regeneration
- Proteomics
- Principal Component Analysis
- Phosphoproteins
- Muscle, Skeletal
- Mice, Inbred C57BL
- Mice
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Bareja, A., Draper, J. A., Katz, L. H., Lee, D. E., Grimsrud, P. A., & White, J. P. (2021). Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. Mech Ageing Dev, 195, 111443. https://doi.org/10.1016/j.mad.2021.111443
Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.
Bareja A, Draper JA, Katz LH, Lee DE, Grimsrud PA, White JP. Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. Mech Ageing Dev. 2021 Apr;195:111443.
Bareja, Akshay, et al. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev, vol. 195, Apr. 2021, p. 111443. Pubmed, doi:10.1016/j.mad.2021.111443.
Bareja A, Draper JA, Katz LH, Lee DE, Grimsrud PA, White JP. Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. Mech Ageing Dev. 2021 Apr;195:111443.
Published In
Mech Ageing Dev
DOI
EISSN
1872-6216
Publication Date
April 2021
Volume
195
Start / End Page
111443
Location
Ireland
Related Subject Headings
- Time
- Signal Transduction
- Rejuvenation
- Regeneration
- Proteomics
- Principal Component Analysis
- Phosphoproteins
- Muscle, Skeletal
- Mice, Inbred C57BL
- Mice